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A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach…

Coarse-graining (CG) of molecular simulations simplifies the particle representation by grouping selected atoms into pseudo-beads and drastically accelerates simulation. However, such CG procedure induces information losses, which makes…

Machine Learning · Computer Science 2022-06-20 Wujie Wang , Minkai Xu , Chen Cai , Benjamin Kurt Miller , Tess Smidt , Yusu Wang , Jian Tang , Rafael Gómez-Bombarelli

We present a loss function for neural networks that encompasses an idea of trivial versus non-trivial predictions, such that the network jointly determines its own prediction goals and learns to satisfy them. This permits the network to…

Artificial Intelligence · Computer Science 2016-12-15 Nicholas Guttenberg , Martin Biehl , Ryota Kanai

Squeezing is known to be a quantum resource in many applications in metrology, cryptography, and computing, being related to entanglement in multimode settings. In this work, we address the effects of squeezing in neuromorphic machine…

Quantum Physics · Physics 2024-02-21 Jorge García-Beni , Gian Luca Giorgi , Miguel C. Soriano , Roberta Zambrini

Understanding temporal processes and their correlations in time is of paramount importance for the development of near-term technologies that operate under realistic conditions. Capturing the complete multi-time statistics defining a…

Quantum Physics · Physics 2020-04-28 Philip Taranto

Classical stochastic processes can be generated by quantum simulators instead of the more standard classical ones, such as hidden Markov models. One reason for using quantum simulators is that they generally require less memory than their…

Quantum Physics · Physics 2016-09-19 C. Aghamohammadi , J. R. Mahoney , J. P. Crutchfield

Quantum computers have the potential to efficiently simulate the dynamics of many interacting quantum particles, a classically intractable task of central importance to fields ranging from chemistry to high-energy physics. However,…

Quantum circuits that generate coherent superpositions of stochastic processes are key to many downstream quantum-accelerated tasks, such as risk analysis, importance sampling, and DNA sequencing. However, traditional methods for designing…

Quantum Physics · Physics 2026-03-26 Ximing Wang , Chengran Yang , Chidambaram Aditya Somasundaram , Jayne Thompson , Mile Gu

Compressive sensing is a sensing protocol that facilitates reconstruction of large signals from relatively few measurements by exploiting known structures of signals of interest, typically manifested as signal sparsity. Compressive…

Quantum Physics · Physics 2022-08-10 Kyle Sherbert , Naveed Naimipour , Haleh Safavi , Harry Shaw , Mojtaba Soltanalian

We present a dynamic coarse-graining technique that allows to simulate the mechanical unfolding of biomolecules or molecular complexes on experimentally relevant time scales. It is based on Markov state models (MSM), which we construct from…

Soft Condensed Matter · Physics 2018-08-17 Fabian Knoch , Ken Schäfer , Gregor Diezemann , Thomas Speck

Quantum machine learning represents a promising avenue for data processing, also for purposes of sequential temporal data analysis, as recently proposed in quantum reservoir computing (QRC). The possibility to operate on several platforms…

Recent advances in deep learning have made available large, powerful convolutional neural networks (CNN) with state-of-the-art performance in several real-world applications. Unfortunately, these large-sized models have millions of…

Machine Learning · Computer Science 2020-07-17 Giosuè Cataldo Marinò , Gregorio Ghidoli , Marco Frasca , Dario Malchiodi

Multiscale molecular modeling is widely applied in scientific research of molecular properties over large time and length scales. Two specific challenges are commonly present in multiscale modeling, provided that information between the…

Computational Physics · Physics 2024-07-23 Jun Zhang , Xiaohan Lin , Weinan E , Yi Qin Gao

Quantum optimization algorithms promise advantages for difficult problems but are costly to simulate and analyze on classical machines. Recently, constrained quantum optimization has been investigated through the lens of Quantum Zeno…

Quantum Physics · Physics 2026-04-28 Max Tschaikowski , Andrea Vandin

We consider the problem of deep neural net compression by quantization: given a large, reference net, we want to quantize its real-valued weights using a codebook with $K$ entries so that the training loss of the quantized net is minimal.…

Machine Learning · Computer Science 2017-07-17 Miguel Á. Carreira-Perpiñán , Yerlan Idelbayev

Quantum machine learning is a rapidly advancing discipline that leverages the features of quantum mechanics to enhance the performance of computational tasks. Quantum reservoir processing, which allows efficient optimization of a single…

High-dimensional recordings of dynamical processes are often characterized by a much smaller set of effective variables, evolving on low-dimensional manifolds. Identifying these latent dynamics requires solving two intertwined problems:…

Machine Learning · Computer Science 2026-01-21 Manuel Hinz , Maximilian Mauel , Patrick Seifner , David Berghaus , Kostadin Cvejoski , Ramses J. Sanchez

Quantum computers promise to enhance machine learning for practical applications. Quantum machine learning for real-world data has to handle extensive amounts of high-dimensional data. However, conventional methods for measuring quantum…

Quantum Physics · Physics 2023-02-10 Tobias Haug , Chris N. Self , M. S. Kim

Numerous molecular systems, including solutions, proteins, and composite materials, can be modeled using mixed-resolution representations, of which the quantum mechanics/molecular mechanics (QM/MM) approach has become the most widely used.…

Chemical Physics · Physics 2018-01-17 Anton V. Sinitskiy , Gregory A. Voth

The development of deep learning algorithms has extensively empowered humanity's task automatization capacity. However, the huge improvement in the performance of these models is highly correlated with their increasing level of complexity,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-19 Eduarda Caldeira , Pedro C. Neto , Marco Huber , Naser Damer , Ana F. Sequeira