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Chemical reaction networks (CRNs) formally model chemistry in a well-mixed solution. CRNs are widely used to describe information processing occurring in natural cellular regulatory networks, and with upcoming advances in synthetic biology,…

Computational Complexity · Computer Science 2013-04-17 David Doty

The R Package IBMPopSim aims to simulate the random evolution of heterogeneous populations using stochastic Individual-Based Models (IBMs). The package enables users to simulate population evolution, in which individuals are characterized…

Populations and Evolution · Quantitative Biology 2024-02-28 Daphné Giorgi , Sarah Kaakai , Vincent Lemaire

The model of chemical reaction networks is among the oldest and most widely studied and used in natural science. The model describes reactions among abstract chemical species, for instance $A + B \to C$, which indicates that if a molecule…

Data Structures and Algorithms · Computer Science 2026-02-16 Joshua Petrack , David Doty

Detailed modeling and simulation of biochemical systems is complicated by the problem of combinatorial complexity, an explosion in the number of species and reactions due to myriad protein-protein interactions and post-translational…

Quantitative Methods · Quantitative Biology 2014-05-20 Justin S. Hogg , Leonard A. Harris , Lori J. Stover , Niketh S. Nair , James R. Faeder

We consider the problem of efficiently simulating population protocols. In the population model, we are given a distributed system of $n$ agents modeled as identical finite-state machines. In each time step, a pair of agents is selected…

Data Structures and Algorithms · Computer Science 2020-05-08 Petra Berenbrink , David Hammer , Dominik Kaaser , Ulrich Meyer , Manuel Penschuck , Hung Tran

An emerging application of Raman spectroscopy is monitoring the state of chemical reactors during biologic drug production. Raman shift intensities scale linearly with the concentrations of chemical species and thus can be used to…

Signal Processing · Electrical Eng. & Systems 2023-06-30 Dexter Antonio , Hannah O'Toole , Randy Carney , Ambarish Kulkarni , Ahmet Palazoglu

Non-equilibrium chemistry is a key process in the study of the InterStellar Medium (ISM), in particular the formation of molecular clouds and thus stars. However, computationally it is among the most difficult tasks to include in…

Astrophysics of Galaxies · Physics 2022-12-07 Lorenzo Branca , Andrea Pallottini

Nuclear coherent population transfer (NCPT) offers numerous potential applications, particularly in next-generation nuclear clocks and nuclear batteries. However, the realization of high fidelity, fast operation, and low energy consumption…

Nuclear Theory · Physics 2026-03-25 Jing Liu , Fu-Quan Dou

Natural microbial communities contain hundreds to thousands of interacting species. For this reason, computational simulations are playing an increasingly important role in microbial ecology. In this manuscript, we present a new…

Populations and Evolution · Quantitative Biology 2020-07-01 Robert Marsland , Wenping Cui , Joshua Goldford , Pankaj Mehta

The Spinsim python package simulates spin-half and spin-one quantum mechanical systems following a time dependent Shroedinger equation. It makes use of numba.cuda, which is an LLVM (Low Level Virtual Machine) compiler for Nvidia Cuda…

Quantum Physics · Physics 2023-03-22 Alex Tritt , Joshua Morris , Joel Hochstetter , R. P. Anderson , James Saunderson , L. D. Turner

Graph Neural Networks (GNNs) are emerging ML models to analyze graph-structure data. Graph Neural Network (GNN) execution involves both compute-intensive and memory-intensive kernels, the latter dominates the total time, being significantly…

Scientific software is often driven by multiple parameters that affect both accuracy and performance. Since finding the optimal configuration of these parameters is a highly complex task, it extremely common that the software is used…

Computational Engineering, Finance, and Science · Computer Science 2016-08-17 Diego Fabregat-Traver , Ahmed E. Ismail , Paolo Bientinesi

The analysis of the evolutionary dynamics of a population with many polymorphic loci is challenging since a large number of possible genotypes needs to be tracked. In the absence of analytical solutions, forward computer simulations are an…

Populations and Evolution · Quantitative Biology 2012-07-31 Fabio Zanini , Richard A. Neher

RPYFMM is a software package for the efficient evaluation of the potential field governed by the Rotne-Prager-Yamakawa (RPY) tensor interactions in biomolecular hydrodynamics simulations. In our algorithm, the RPY tensor is decomposed as a…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-04-04 W. Guan , X. Cheng , J. Huang , G. Huber , W. Li , J. A. McCammon , B. Zhang

We introduce the `nhppp' package for simulating events from one-dimensional non-homogeneous Poisson point processes (NHPPPs) in R fast and with a small memory footprint. We developed it to facilitate the sampling of event times in discrete…

Computation · Statistics 2024-05-30 Thomas A. Trikalinos , Yuliia Sereda

Automating experimental protocol design and execution remains as a fundamental bottleneck in realizing self-driving laboratories. We introduce PRISM (Protocol Refinement through Intelligent Simulation Modeling), a framework that automates…

Inferring chemical reaction networks (CRN) from concentration time series is a challenge encouragedby the growing availability of quantitative temporal data at the cellular level. This motivates thedesign of algorithms to infer the…

Quantitative Methods · Quantitative Biology 2023-02-09 Julien Martinelli , Jeremy Grignard , Sylvain Soliman , Annabelle Ballesta , François Fages

Analysis of large continuous-time stochastic systems is a computationally intensive task. In this work we focus on population models arising from chemical reaction networks (CRNs), which play a fundamental role in analysis and design of…

Systems and Control · Computer Science 2019-05-27 Milan Češka , Jan Křetínský

In this article we present PARSIR (PARallel SImulation Runner), a package that enables the effective exploitation of shared-memory multi-processor machines for running discrete event simulation models. PARSIR is a compile/run-time…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-02 Francesco Quaglia

We introduce QDsim, a python package tailored for the rapid generation of charge stability diagrams in large-scale quantum dot devices, extending beyond traditional double or triple dots. QDsim is founded on the constant interaction model…

Mesoscale and Nanoscale Physics · Physics 2025-01-29 Valentina Gualtieri , Charles Renshaw-Whitman , Vinicius Hernandes , Eliska Greplova
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