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Integral membrane proteins deform the surrounding bilayer creating long-ranged forces that influence distant proteins. These forces can be attractive or repulsive, depending on the proteins' shape, height, contact angle with the bilayer, as…

Statistical Mechanics · Physics 2007-05-23 Tom Chou , Ken S. Kim , George Oster

Demand for lower computing power has rapidly increased. In this context, brain-inspired neuromorphic computing, which integrate data storage and processing, has attracted significant attention. Here, our study reveals that field effect…

Lipid membranes, fundamental to cellular function, undergo various mechanical deformations. Accurate modeling of these processes necessitates a thorough understanding of membrane elasticity. The lateral shear modulus, a critical parameter…

Soft Condensed Matter · Physics 2024-12-02 Konstantin V. Pinigin

We investigate the properties of membranes under tension by Monte-Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area…

Biological Physics · Physics 2010-03-17 Jörg Neder , Beate West , Peter Nielaba , Friederike Schmid

Understanding how lipid bilayers respond to pressure is essential for interpreting the coupling between membrane proteins and their native environments. Here, we use all-atom molecular dynamics to examine the pressure-temperature behavior…

Soft Condensed Matter · Physics 2026-01-12 Yanna Gautier , Guillaume Stirnemann , Jérôme Hénin

We theoretically investigate the relaxation dynamics of a nearly-flat binary lipid bilayer membrane by taking into account the membrane tension, hydrodynamics of the surrounding fluid, inter-monolayer friction and mutual diffusion in each…

Soft Condensed Matter · Physics 2016-05-05 Ryuichi Okamoto , Yuichi Kanemori , Shigeyuki Komura , Jean-Baptiste Fournier

We present a mathematical model of polymer bilayers that undergo large bending deformations when actuated by non-mechanical stimuli such as thermal effects. The simple model captures a large class of nonlinear bending effects and can be…

Numerical Analysis · Mathematics 2017-12-06 Soeren Bartels , Andrea Bonito , Anastasia Muliana , Ricardo H. Nochetto

Cells offer numerous inspiring examples where proteins and membranes combine to form complex structures that are key to intracellular compartmentalization, cargo transport, and specialization of cell morphology. Despite this wealth of…

We have studied biomembranes with grafted polymer chains using a coarse-grained membrane simulation, where a meshless membrane model is combined with polymer chains. We focus on the polymer-induced entropic effects on mechanical properties…

Biological Physics · Physics 2024-12-05 Hao Wu , Hiroshi Noguchi

Biomembranes wrapping cells and organelles are not only the partitions that separate the insides but also dynamic fields for biological functions accompanied by membrane shape changes. In this review, we discuss the spatiotemporal patterns…

Soft Condensed Matter · Physics 2025-01-22 Hiroshi Noguchi

We consider a three-dimensional network of aqueous droplets joined by single lipid bilayers to form a cohesive, tissue-like material. The droplets in these networks can be programmed to have distinct osmolarities so that osmotic gradients…

Soft Condensed Matter · Physics 2016-03-23 T. Zhang , Duanduan Wan , J. M. Schwarz , M. J. Bowick

Continuum or hybrid modeling of bilayer membrane morphological dynamics induced by embedded proteins necessitates the identification of protein-membrane interfaces and coupling of deformations of two surfaces. In this article we developed…

Soft Condensed Matter · Physics 2020-06-29 Y. C. Zhou , David Argudo , Frank Marcoline , Michael Grabe

The physicochemical properties of lipid bilayers (membranes) are closely associated with various cellular functions and are often evaluated using absorption and fluorescence spectroscopies. For instance, by employing fluorescent probes that…

Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair…

Subcellular Processes · Quantitative Biology 2017-12-25 Francesco Gianoli , Thomas Risler , Andrei S. Kozlov

Polypropylene (PP) is a widely used polymer matter, which has many advantages, such as rich sources, simple synthesis process, small density, low cost, easy processing and molding. At present, there has been a lot of progress in the…

Soft Condensed Matter · Physics 2023-10-13 Li L. Zhang , Zihan Huang , Chunlei Hao , Lai Peng , Jun X. Huang

We investigate a model of an asymmetric bilayer consisting of sphigomyelin, phosphatidylcholine, and cholesterol in the outer leaflet, and phosphatidyl\-ethanolamine, (PE), phosphatidylserine, and cholesterol in the inner leaflet.…

Soft Condensed Matter · Physics 2016-08-23 H. Giang , M. Schick

Local changes in pH are known to significantly alter the state and activity of proteins and in particular enzymes. pH variations induced by pulses propagating along soft interfaces (e.g. the lipid bilayer) would therefore constitute an…

Biological Physics · Physics 2015-03-18 Bernhard Fichtl , Shamit Shrivastava , Matthias F. Schneider

We study a minimal extension of the worm-like chain to describe polypeptides having alpha-helical secondary structure. In this model presence/absence of secondary structure enters as a scalar variable that controls the local chain bending…

Statistical Mechanics · Physics 2009-11-10 Buddhapriya Chakrabarti , Alex J. Levine

There is mounting evidence that lipid bilayers display conductive properties. However, when interpreting the electrical response of biological membranes to voltage changes, they are commonly considered as inert insulators. However, lipid…

Biological Physics · Physics 2022-11-24 Karis A. Zecchi , Thomas Heimburg

We study the elastic response of bilayer membranes with fixed projected area to both stretching and shape deformations. A surface tension is associated to each of these deformations. By using model amphiphilic membranes and computer…

Soft Condensed Matter · Physics 2009-11-11 Alberto Imparato