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The rates-across-sites assumption in phylogenetic inference posits that the rate matrix governing the Markovian evolution of a character on an edge of the putative phylogenetic tree is the product of a character-specific scale factor and a…

Populations and Evolution · Quantitative Biology 2007-05-23 Steven N. Evans , Tandy Warnow

These lecture notes introduce the statistical analysis of continuous-time generative models built from Markov dynamics. We begin with the stochastic-calculus foundations of score-based diffusion models, including time reversal, score…

Statistics Theory · Mathematics 2026-04-27 Eddie Aamari , Arthur Stéphanovitch

We investigate the properties of uniform doubly stochastic random matrices, that is non-negative matrices conditioned to have their rows and columns sum to 1. The rescaled marginal distributions are shown to converge to exponential…

Probability · Mathematics 2010-11-01 Sourav Chatterjee , Persi Diaconis , Allan Sly

Integrating a product of linear forms over the unit simplex can be done in polynomial time if the number of variables n is fixed (V. Baldoni et al., 2011). In this note, we highlight that this problem is equivalent to obtaining the…

Performance · Computer Science 2026-03-16 Giuliano Casale

Many biological and medical questions can be modeled using time-to-event data in finite-state Markov chains, with the phase-type distribution describing intervals between events. We solve the inverse problem: given a phase-type…

Dynamical Systems · Mathematics 2024-11-19 Ovidiu Radulescu , Dima Grigoriev , Matthias Seiss , Maria Douaihy , Mounia Lagha , Edouard Bertrand

When the process underlying DNA substitutions varies across evolutionary history, the standard Markov models underlying standard phylogenetic methods are mathematically inconsistent. The most prominent example is the general time reversible…

Populations and Evolution · Quantitative Biology 2014-12-05 Michael D. Woodhams , Jesús Fernández-Sánchez , Jeremy G. Sumner

We prove that the probability substitution matrices obtained from a continuous-time Markov chain form a multiplicatively closed set if and only if the rate matrices associated to the chain form a linear space spanning a Lie algebra. The key…

Group Theory · Mathematics 2017-09-04 Jeremy G Sumner

This paper is devoted to the study of preservation of eigenvalues, Jordan structure and complementary invariant subspaces of structured matrices under structured perturbations. Perturbations and structure-preserving perturbations are…

Numerical Analysis · Mathematics 2020-06-18 Tinku Ganai , Bibhas Adhikari

Understanding and predicting how complex systems respond to external perturbations is a central challenge in nonequilibrium statistical physics. Here we consider continuous-time Markov networks, which we subject to perturbations along a…

Statistical Mechanics · Physics 2026-02-25 Robin Bebon , Thomas Speck

We address a class of Markov jump linear systems that are characterized by the underlying Markov process being time-inhomogeneous with a priori unknown transition probabilities. Necessary and sufficient conditions for uniform stochastic…

Systems and Control · Computer Science 2014-11-24 Collin C. Lutz , Daniel J. Stilwell

Synchronizability of stable, output-coupled, identical, time-varying linear systems is studied. It is shown that if the observability grammian satisfies a persistence of excitation condition, then there exists a bounded, time-varying linear…

Dynamical Systems · Mathematics 2008-11-24 S. Emre Tuna

We consider Hidden Markov Models that emit sequences of observations that are drawn from continuous distributions. For example, such a model may emit a sequence of numbers, each of which is drawn from a uniform distribution, but the support…

Logic in Computer Science · Computer Science 2020-09-29 Oscar Darwin , Stefan Kiefer

McDonald and Paparella [Linear Algebra Appl. 498 (2016), 145--159] gave a necessary condition on the structure of Jordan chains of $h$-cyclic matrices. In this work, that necessary condition is shown to be sufficient. As a consequence, we…

Spectral Theory · Mathematics 2021-10-20 Andrew L. Nickerson , Pietro Paparella

Markov chains for probability distributions related to matrix product states and 1D Hamiltonians are introduced. With appropriate 'inverse temperature' schedules, these chains can be combined into a random approximation scheme for ground…

Strongly Correlated Electrons · Physics 2014-05-14 S. Iblisdir

A special class of Jordan algebras over a field $F$ of characteristic zero is considered. Such an algebra consists of an $r$-dimensional subspace of the vector space of all square matrices of a fixed order $n$ over $F$. It contains the…

Combinatorics · Mathematics 2019-11-15 Mikhail Klin , Mikhail Muzychuk , Sven Reichard

Characterizing whether a Markov process of discrete random variables has an homogeneous continuous-time realization is a hard problem. In practice, this problem reduces to deciding when a given Markov matrix can be written as the…

Probability · Mathematics 2021-06-23 Marta Casanellas , Jesús Fernández-Sánchez , Jordi Roca-Lacostena

Let $M_n(R)$ be the algebra of all $n\times n$ matrices over a unital commutative ring $R$ with 6 invertible. We say that $A\in M_n(R)$ is a Jordan product determined point if for every $R$-module $X$ and every symmetric $R$-bilinear map…

Operator Algebras · Mathematics 2011-11-18 Yang Wenlei , Zhu Jun

We consider novel phylogenetic models with rate matrices that arise via the embedding of a progenitor model on a small number of character states, into a target model on a larger number of character states. Adapting representation-theoretic…

Quantitative Methods · Quantitative Biology 2010-08-09 P. D. Jarvis , J. G. Sumner

We derive a generalization of the Perron-Frobenius theorem to time-varying row-stochastic matrices as follows: using Kolmogorov's concept of absolute probability sequences, which are time-varying analogs of principal eigenvectors, we…

Optimization and Control · Mathematics 2024-12-06 Rohit Parasnis , Massimo Franceschetti , Behrouz Touri

Inspired from non-equilibrium statistical physics models, a general framework enabling the definition and synthesis of stationary time series with a priori prescribed and controlled joint distributions is constructed. Its central feature…

Statistical Mechanics · Physics 2016-11-17 Florian Angeletti , Eric Bertin , Patrice Abry