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A new ensemble framework for interpretable model called Linear Iterative Feature Embedding (LIFE) has been developed to achieve high prediction accuracy, easy interpretation and efficient computation simultaneously. The LIFE algorithm is…

Machine Learning · Statistics 2021-03-19 Agus Sudjianto , Jinwen Qiu , Miaoqi Li , Jie Chen

Machine learning enables extracting clinical insights from large temporal datasets. The applications of such machine learning models include identifying disease patterns and predicting patient outcomes. However, limited interpretability…

Machine Learning · Computer Science 2023-11-30 Yu Chen , Nivedita Bijlani , Samaneh Kouchaki , Payam Barnaghi

Early detection of Alzheimer's disease (AD) is crucial because its neurodegenerative effects are irreversible, and neuropathologic and social-behavioral risk factors accumulate years before diagnosis. Identifying higher-risk individuals…

Machine Learning · Computer Science 2025-10-14 Xi Mao , Zhendong Wang , Jingyu Li , Lingchao Mao , Utibe Essien , Hairong Wang , Xuelei Sherry Ni

Single neurons in neural networks are often interpretable in that they represent individual, intuitively meaningful features. However, many neurons exhibit $\textit{mixed selectivity}$, i.e., they represent multiple unrelated features. A…

Machine Learning · Statistics 2023-10-19 David Klindt , Sophia Sanborn , Francisco Acosta , Frédéric Poitevin , Nina Miolane

The integration of Deep Learning (DL) in System Dynamics (SD) modeling for transportation logistics offers significant advantages in scalability and predictive accuracy. However, these gains are often offset by the loss of explainability…

Artificial Intelligence · Computer Science 2025-09-11 Riccardo D'Elia , Alberto Termine , Francesco Flammini

At the physiological level, aging is neither rigid nor unchangeable. Instead, the molecular and mechanisms driving aging are sufficiently plastic that a variety of diverse interventions--dietary, pharmaceutical, and genetic--have been…

Quantitative Methods · Quantitative Biology 2018-08-28 Nicholas Stroustrup

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Recent technological advances and long-term data studies provide interaction data that can be modelled through dynamic networks, i.e a sequence of different snapshots of an evolving ecological network. Most often time is the parameter along…

Populations and Evolution · Quantitative Biology 2017-01-06 Vincent Miele , Catherine Matias

Human brains lie at the core of complex neurobiological systems, where the neurons, circuits, and subsystems interact in enigmatic ways. Understanding the structural and functional mechanisms of the brain has long been an intriguing pursuit…

Neurons and Cognition · Quantitative Biology 2022-07-26 Hejie Cui , Wei Dai , Yanqiao Zhu , Xiaoxiao Li , Lifang He , Carl Yang

The lack of interpretability and transparency are preventing economists from using advanced tools like neural networks in their empirical research. In this paper, we propose a class of interpretable neural network models that can achieve…

Econometrics · Economics 2020-12-01 Yucheng Yang , Zhong Zheng , Weinan E

The use of wearables in medicine and wellness, enabled by AI-based models, offers tremendous potential for real-time monitoring and interpretable event detection. Explainable AI (XAI) is required to assess what models have learned and build…

Signal Processing · Electrical Eng. & Systems 2026-03-16 Maurice Kuschel , Solveig Vieluf , Claus Reinsberger , Tobias Loddenkemper , Tanuj Hasija

We discuss our insights into interpretable artificial-intelligence (AI) models, and how they are essential in the context of developing ethical AI systems, as well as data-driven solutions compliant with the Sustainable Development Goals…

Machine Learning · Computer Science 2021-08-25 Ricardo Vinuesa , Beril Sirmacek

Predicting high-dimensional or extreme multilabels, such as in medical coding, requires both accuracy and interpretability. Existing works often rely on local interpretability methods, failing to provide comprehensive explanations of the…

Computation and Language · Computer Science 2025-03-25 John Wu , David Wu , Jimeng Sun

Cardiovascular disease (CVD) remains a critical global health concern, demanding reliable and interpretable predictive models for early risk assessment. This study presents a large-scale analysis using the Heart Disease Health Indicators…

Machine Learning · Computer Science 2025-11-05 Md Abrar Hasnat , Md Jobayer , Md. Mehedi Hasan Shawon , Md. Golam Rabiul Alam

In general, many dynamic processes are involved with interacting variables, from physical systems to sociological analysis. The interplay of components in the system can give rise to confounding dynamic behavior. Many approaches model…

Artificial Intelligence · Computer Science 2021-06-02 Qianyu Feng , Bang Zhang , Yi Yang

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

How can we find interpretable, domain-appropriate models of natural phenomena given some complex, raw data such as images? Can we use such models to derive scientific insight from the data? In this paper, we propose some methods for…

Machine Learning · Computer Science 2024-02-06 Christopher J. Soelistyo , Alan R. Lowe

Interpretation of deep learning models is a very challenging problem because of their large number of parameters, complex connections between nodes, and unintelligible feature representations. Despite this, many view interpretability as a…

Machine Learning · Computer Science 2021-03-05 Michael Tsang , James Enouen , Yan Liu

Precision medicine has received attention both in and outside the clinic. We focus on the latter, by exploiting the relationship between individuals' social interactions and their mental health to develop a predictive model of one's…

Social and Information Networks · Computer Science 2019-08-08 Shikang Liu , David Hachen , Omar Lizardo , Christian Poellabauer , Aaron Striegel , Tijana Milenkovic

The field of health informatics has been profoundly influenced by the development of random forest models, which have led to significant advances in the interpretability of feature interactions. These models are characterized by their…

Machine Learning · Computer Science 2025-06-04 Akshat Dubey , Aleksandar Anžel , Georges Hattab