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We present work flows and a software module for machine learning model building in surface science and heterogeneous catalysis. This includes fingerprinting atomic structures from 3D structure and/or connectivity information, it includes…

Quantum chemical calculations on atomistic systems have evolved into a standard approach to study molecular matter. These calculations often involve a significant amount of manual input and expertise although most of this effort could be…

Exploring large chemical reaction networks with automated exploration approaches and accurate quantum chemical methods can require prohibitively large computational resources. Here, we present an automated exploration approach that focuses…

Chemical Physics · Physics 2024-06-12 Moritz Bensberg , Markus Reiher

We have developed an end-to-end, retrosynthesis system, named ChemiRise, that can propose complete retrosynthesis routes for organic compounds rapidly and reliably. The system was trained on a processed patent database of over 3 million…

Chemical Physics · Physics 2021-08-11 Xiangyan Sun , Ke Liu , Yuquan Lin , Lingjie Wu , Haoming Xing , Minghong Gao , Ji Liu , Suocheng Tan , Zekun Ni , Qi Han , Junqiu Wu , Jie Fan

Modern computational chemistry has reached a stage at which massive exploration into chemical reaction space with unprecedented resolution with respect to the number of potentially relevant molecular structures has become possible. Various…

Chemical Physics · Physics 2020-04-27 Jan P. Unsleber , Markus Reiher

Automating the development of machine learning algorithms has the potential to unlock new breakthroughs. However, our ability to improve and evaluate algorithm discovery systems has thus far been limited by existing task suites. They suffer…

Investigating a reactive chemical system with automated reaction network exploration algorithms provides a more detailed picture of its chemical mechanism than what would be accessible by manual investigation. In general, exploration…

Chemical Physics · Physics 2023-04-14 Moritz Bensberg , Markus Reiher

Automated Machine Learning (AutoML) is used more than ever before to support users in determining efficient hyperparameters, neural architectures, or even full machine learning pipelines. However, users tend to mistrust the optimization…

Machine Learning · Computer Science 2022-07-12 René Sass , Eddie Bergman , André Biedenkapp , Frank Hutter , Marius Lindauer

Autonomous computations that rely on automated reaction network elucidation algorithms may pave the way to make computational catalysis on a par with experimental research in the field. Several advantages of this approach are key to…

Materials Science · Physics 2022-03-18 Miguel Steiner , Markus Reiher

As shown by recent studies, machine intelligence-enabled systems are vulnerable to test cases resulting from either adversarial manipulation or natural distribution shifts. This has raised great concerns about deploying machine learning…

Robotics · Computer Science 2022-11-01 Chejian Xu , Wenhao Ding , Weijie Lyu , Zuxin Liu , Shuai Wang , Yihan He , Hanjiang Hu , Ding Zhao , Bo Li

The software for chemical interaction networks (SCINE) project aims at pushing the frontier of quantum chemical calculations on molecular structures to a new level. While calculations on individual structures as well as on simple relations…

We developed an automated approach to construct the complex reaction network and explore the reaction mechanism for several reactant molecules. The nanoreactor type molecular dynamics was employed to generate possible chemical reactions, in…

Chemical Physics · Physics 2023-12-05 Yutai Zhang , Chao Xu , Zhenggang Lan

We present SynRXN, a unified benchmarking framework and open-data resource for computer-aided synthesis planning (CASP). SynRXN decomposes end-to-end synthesis planning into five task families, covering reaction rebalancing, atom-to-atom…

Machine Learning · Computer Science 2026-04-21 Tieu-Long Phan , Nhu-Ngoc Nguyen Song , Peter F. Stadler

Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models…

Accurate identification of chemical species and reaction pathways from molecular dynamics (MD) trajectories is a prerequisite for deriving predictive chemical-kinetic models and for mechanistic discovery in reactive systems. However,…

Computational Physics · Physics 2026-01-14 Raj Maddipati , Dhruthi Boddapati , Elangannan Arunan , Phani Motamarri , Konduri Aditya

Automated laboratory experiments have the potential to propel new discoveries, while increasing reproducibility and improving scientists' safety when handling dangerous materials. However, many automated laboratory workflows have not fully…

Robotics · Computer Science 2025-06-26 Hatem Fakhruldeen , Gabriella Pizzuto , Jakub Glowacki , Andrew Ian Cooper

The advent of simulation engines has revolutionized learning and operational efficiency for robots, offering cost-effective and swift pipelines. However, the lack of a universal simulation platform tailored for chemical scenarios impedes…

Robotics · Computer Science 2024-06-13 Shoujie Li , Yan Huang , Changqing Guo , Tong Wu , Jiawei Zhang , Linrui Zhang , Wenbo Ding

Mine fleet management algorithms can significantly reduce operational costs and enhance productivity in mining systems. Most current fleet management algorithms are evaluated based on self-implemented or proprietary simulation environments,…

Multiagent Systems · Computer Science 2024-04-02 Shi Meng , Bin Tian , Xiaotong Zhang , Shuangying Qi , Caiji Zhang , Qiang Zhang

This paper introduces AutoREC, an open-source Python package for developing reinforcement learning (RL) agents to automatically generate equivalent circuit models (ECMs) from electrochemical impedance spectroscopy (EIS) data. While ECMs are…

The automated extraction of chemical structures and their corresponding bioactivity data is essential for accelerating drug discovery and enabling data-driven research. Current optical chemical structure recognition tools lack the…

Quantitative Methods · Quantitative Biology 2026-03-04 Zhe Wang , Fangtian Fu , Wei Zhang , Lige Yan , Nan Li , Wenxia Deng , Yan Meng , Jianping Wu , Hui Wu , Wenting Wu , Gang Xu , Xiang Li , Si Chen