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Combinatorial optimization problems play a central role in computer science with many real world applications. A number of relevant problems remain computationally difficult to solve as they lie in the NP-hard complexity class. We present a…

Quantum Physics · Physics 2026-05-11 Kapil Goswami , Peter Schmelcher

Quadratic Unconstrained Binary Optimization (QUBO) is recognized as a unifying framework for modeling a wide range of problems. Problems can be solved with commercial solvers customized for solving QUBO and since QUBO have degree two, it is…

Optimization and Control · Mathematics 2021-07-27 Amit Verma , Mark Lewis , Gary Kochenberger

We introduce a physics-inspired continuous relaxation framework that yields substantially improved solutions for NP-hard combinatorial optimization problems, including Quadratic Unconstrained Binary Optimization (QUBO), binary sparse…

Statistical Mechanics · Physics 2026-05-26 Khen Cohen , Mark Glass , Meir Feder , Yaron Oz

Quadratic unconstrained binary optimization (QUBO) problems are well-studied, not least because they can be approached using contemporary quantum annealing or classical hardware acceleration. However, due to limited precision and hardware…

Quantum Physics · Physics 2023-07-06 Sascha Mücke , Thore Gerlach , Nico Piatkowski

Quantum annealing devices such as the ones produced by D-Wave systems are typically used for solving optimization and sampling tasks, and in both academia and industry the characterization of their usefulness is subject to active research.…

Quantum annealing is a powerful tool for solving and approximating combinatorial optimization problems such as graph partitioning, community detection, centrality, routing problems, and more. In this paper we explore the use of quantum…

Quantum Physics · Physics 2025-07-17 Joel E. Pion , Susan M. Mniszewski

Linear regression is a popular machine learning approach to learn and predict real valued outputs or dependent variables from independent variables or features. In many real world problems, its beneficial to perform sparse linear regression…

Machine Learning · Computer Science 2021-06-07 Surya Sai Teja Desu , P. K. Srijith , M. V. Panduranga Rao , Naveen Sivadasan

Quantum annealers offer a promising hardware platform for solving combinatorial optimization problems, especially those formulated as Quadratic Unconstrained Binary Optimization (QUBO). In this work, we propose PDQUBO (Performance-Driven…

Information Retrieval · Computer Science 2026-05-01 Jiayang Niu , Jie Li , Ke Deng , Mark Sanderson , Nicola Ferro , Yongli Ren

A range of quantum algorithms, especially those leveraging variational parameterization and circuit-based optimization, are being studied as alternatives for solving classically intractable combinatorial optimization problems (COPs).…

Quantum Physics · Physics 2025-06-18 Monit Sharma , Hoong Chuin Lau

Graph partitioning is one of an important set of well-known compute-intense (NP-hard) graph problems that devolve to discrete constrained optimization. We sampled solutions to the problem via two different quantum-ready methods to…

Using Quantum Computers to solve problems in Recommender Systems that classical computers cannot address is a worthwhile research topic. In this paper, we use Quantum Annealers to address the feature selection problem in recommendation…

Information Retrieval · Computer Science 2024-07-04 Jiayang Niu , Jie Li , Ke Deng , Yongli Ren

Quantum machine learning models use encoding circuits to map data into a quantum Hilbert space. While it is well known that the architecture of these circuits significantly influences core properties of the resulting model, they are often…

Quantum Physics · Physics 2025-03-03 Frederic Rapp , David A. Kreplin , Marco F. Huber , Marco Roth

We present a novel formulation of structural design optimization problems specifically tailored to be solved by quantum annealing (QA). Structural design optimization aims to find the best, i.e., material-efficient yet high-performance,…

Computational Engineering, Finance, and Science · Computer Science 2024-04-17 Fabian Key , Lukas Freinberger

Quantum computing offers significant potential for solving NP-hard combinatorial (optimization) problems that are beyond the reach of classical computers. One way to tap into this potential is by reformulating combinatorial problems as a…

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

Feature selection is crucial for enhancing the accuracy and efficiency of machine learning (ML) models. This work investigates the utility of quantum annealing for the feature selection process in an ML-pipeline, used for maximizing the…

Quantum Physics · Physics 2024-12-02 Daniel Pranjic , Bharadwaj Chowdary Mummaneni , Christian Tutschku

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

We present QuantumSync, the first quantum algorithm for solving a synchronization problem in the context of computer vision. In particular, we focus on permutation synchronization which involves solving a non-convex optimization problem in…

Quantum Physics · Physics 2021-11-29 Tolga Birdal , Vladislav Golyanik , Christian Theobalt , Leonidas Guibas

Matrix Factorization has emerged as a widely adopted framework for modeling data exhibiting low-rank structures. To address challenges in manifold learning, this paper presents a subspace-constrained quadratic matrix factorization model.…

Machine Learning · Computer Science 2024-11-08 Zheng Zhai , Xiaohui Li

Variational quantum algorithms have been advocated as promising candidates to solve combinatorial optimization problems on near-term quantum computers. Their methodology involves transforming the optimization problem into a quadratic…

Quantum Physics · Physics 2023-08-01 Zoé Verchère , Sourour Elloumi , Andrea Simonetto
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