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Titanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a…

Cell Behavior · Quantitative Biology 2020-07-02 Matej Daniel , Kristina Eleršič Filipič , Eva Filová , Jaroslav Fojt

We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving…

Analysis of PDEs · Mathematics 2020-02-11 Inwon Kim , Jiajun Tong

A new diffuse interface model for a two-phase flow of two incompressible fluids with different densities is introduced using methods from rational continuum mechanics. The model fulfills local and global dissipation inequalities and is…

Fluid Dynamics · Physics 2011-04-08 H. Abels , H. Garcke , G. Grün

We consider the asymptotic limit of a diffuse interface model for tumor-growth when a parameter $\varepsilon$ proportional to the thickness of the diffuse interface goes to zero. An approximate solution which shows explicitly the behavior…

Analysis of PDEs · Mathematics 2017-08-25 Mingwen Fei , Tao Tao , Wei Wang

We present an experimental study of immiscible, two-phase fluid flow through a three-dimensional porous medium consisting of randomly-packed, monodisperse glass spheres. Our experiments combine refractive-index matching and laser-induced…

Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…

Tissues and Organs · Quantitative Biology 2019-07-16 Joe Eyles , John F. King , Vanessa Styles

We prove local well-posedness for the Muskat problem on the half-plane, which models motion of an interface between two fluids of distinct densities (e.g., oil and water) in a porous medium (e.g., an aquifer) that sits atop an impermeable…

Analysis of PDEs · Mathematics 2024-10-17 Andrej Zlatos

We present a model for cell growth, division and packing under soft constraints that arise from the deformability of the cells as well as of a membrane that encloses them. Our treatment falls within the framework of diffuse interface…

Cell Behavior · Quantitative Biology 2019-01-09 J. Jiang , K. Garikipati , S. Rudraraju

The propagation of nonlinear waves in one dimensional space, unsteady and compressible flow in Darcy-type porous media is analyzed. It is assumed that the weak discontinuity propagate long the characteristic path using the characteristics…

Fluid Dynamics · Physics 2019-07-24 Mithilesh Singh

Flood front is the jump interface where fluids distribute discontinuously, whose interface condition is the theoretical basis of a mathematical model of the multiphase flow in porous medium. The conventional interface condition at the jump…

Fluid Dynamics · Physics 2017-07-05 Xiaolong Peng , Yong Liu , Baosheng Liang

Using techniques of the theory of semigroups of linear operators we study the question of approximating solutions to equations governing diffusion in thin layers separated by a semi-permeable membrane. We show that as thickness of the…

Analysis of PDEs · Mathematics 2019-08-08 Adam Bobrowski

We consider an incompressible Bingham flow in a thin domain with rough boundary, under the action of given external forces and with no-slip boundary condition on the whole boundary of the domain. In mathematical terms, this problem is…

Analysis of PDEs · Mathematics 2024-01-30 Giuseppe Cardone , Carmen Perugia , Manuel Villanueva Pesqueira

We investigate the limiting behavior of the Navier-Stokes-Cahn-Hilliard model for binary-fluid flows as the diffuse-interface thickness passes to zero, in the presence of fluid-fluid-solid contact lines. Allowing for motion of such contact…

Numerical Analysis · Mathematics 2024-07-09 T. H. B. Demont , S. K. F. Stoter , C. Diddens , E. H. van Brummelen

The method of matched asymptotic expansions is used to study the canonical problem of steady laminar flow through a narrow two-dimensional channel blocked by a tight-fitting finite-length highly permeable porous obstacle. We investigate the…

Fluid Dynamics · Physics 2016-12-05 Mohit P. Dalwadi , S. Jonathan Chapman , Sarah L. Waters , James M. Oliver

This study builds upon a model proposed by Joanny and collaborators that examines the dynamics of interfaces between two distinct cell populations, particularly during tumor growth in healthy tissues. This framework leads to the…

Analysis of PDEs · Mathematics 2024-09-20 Juan Campos , Carlos Pulido , Juan Soler

This study investigates the steady-state Darcy-Brinkman flow within a thin, saturated porous domain, focusing on the effects of viscous dissipation and non-homogeneous boundary condition for the temperature. Employing asymptotic techniques…

Analysis of PDEs · Mathematics 2025-08-07 Igor Pažanin , Francisco J. Suárez-Grau

At the continuous level, we consider two types of tumor growth models: the cell density model, which is based on the fluid mechanical construction, is more favorable for scientific interpretation and numerical simulations; and the free…

Analysis of PDEs · Mathematics 2019-10-28 Jian-Guo Liu , Min Tang , Li Wang , Zhennan Zhou

Numerical methods are developed to simulate the wave propagation in heterogeneous 2D fluid / poroelastic media. Wave propagation is described by the usual acoustics equations (in the fluid medium) and by the low-frequency Biot's equations…

Classical Physics · Physics 2012-09-25 Guillaume Chiavassa , Bruno Lombard

We consider a Fisher-KPP equation with density-dependent diffusion and advection, arising from a chemotaxis-growth model. We study its behavior as a small parameter, related to the thickness of a diffuse interface, tends to zero. We…

Analysis of PDEs · Mathematics 2011-04-20 Matthieu Alfaro , Elisabeth Logak

We perform direct numerical simulations of the flow through a model of a deformable porous medium. Our model is a two-dimensional hexagonal lattice, with defects, of soft elastic cylindrical pillars, with elastic shear modulus $G$, immersed…

Fluid Dynamics · Physics 2021-09-09 Marco E. Rosti , Satyajit Pramanik , Luca Brandt , Dhrubaditya Mitra