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Segmentation of anatomical structures and pathologies is inherently ambiguous. For instance, structure borders may not be clearly visible or different experts may have different styles of annotating. The majority of current state-of-the-art…

Computational models provide crucial insights into complex biological processes such as cancer evolution, but their mechanistic nature often makes them nonlinear and parameter-rich, complicating calibration. We systematically evaluate…

Analysis of PDEs · Mathematics 2025-09-24 Christina Schenk , Jacobo Ayensa Jiménez , Ignacio Romero

We develop a novel statistical strong lensing approach to probe the cosmological parameters by exploiting multiple redshift image systems behind galaxies or galaxy clusters. The method relies on free-form mass inversion of strong lenses and…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-17 M. Lubini , M. Sereno , J. Coles , Ph. Jetzer , P. Saha

We propose a Bayesian approximate inference method for learning the dependence structure of a Gaussian graphical model. Using pseudo-likelihood, we derive an analytical expression to approximate the marginal likelihood for an arbitrary…

Machine Learning · Statistics 2017-04-13 Janne Leppä-aho , Johan Pensar , Teemu Roos , Jukka Corander

We develop a computational framework to quantify uncertainty in shear elastography imaging of anomalies in tissues. We adopt a Bayesian inference formulation. Given the observed data, a forward model and their uncertainties, we find the…

Numerical Analysis · Mathematics 2023-06-07 Ana Carpio , Elena Cebrian , Andrea Gutierrez

This work proposes $\mu$GUIDE: a general Bayesian framework to estimate posterior distributions of tissue microstructure parameters from any given biophysical model or MRI signal representation, with exemplar demonstration in…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Maëliss Jallais , Marco Palombo

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Visual segmentation is a key perceptual function that partitions visual space and allows for detection, recognition and discrimination of objects in complex environments. The processes underlying human segmentation of natural images are…

Computer Vision and Pattern Recognition · Computer Science 2019-05-03 Jonathan Vacher , Pascal Mamassian , Ruben Coen-Cagli

Simulation-based Bayesian inference (SBI) can be used to estimate the parameters of complex mechanistic models given observed model outputs without requiring access to explicit likelihood evaluations. A prime example for the application of…

Machine Learning · Computer Science 2022-11-28 Jonas Beck , Michael Deistler , Yves Bernaerts , Jakob Macke , Philipp Berens

Reliably predicting the future spread of brain tumors using imaging data and on a subject-specific basis requires quantifying uncertainties in data, biophysical models of tumor growth, and spatial heterogeneity of tumor and host tissue.…

Computational Engineering, Finance, and Science · Computer Science 2022-09-27 Baoshan Liang , Jingye Tan , Luke Lozenski , David A. Hormuth , Thomas E. Yankeelov , Umberto Villa , Danial Faghihi

Image segmentation is an important component of many image understanding systems. It aims to group pixels in a spatially and perceptually coherent manner. Typically, these algorithms have a collection of parameters that control the degree…

Computer Vision and Pattern Recognition · Computer Science 2018-02-02 Marc Bosch , Christopher M. Gifford , Austin G. Dress , Clare W. Lau , Jeffrey G. Skibo , Gordon A. Christie

Fully convolutional U-shaped neural networks have largely been the dominant approach for pixel-wise image segmentation. In this work, we tackle two defects that hinder their deployment in real-world applications: 1) Predictions lack…

Computer Vision and Pattern Recognition · Computer Science 2021-06-29 Martin Ferianc , Divyansh Manocha , Hongxiang Fan , Miguel Rodrigues

Deep learning-based segmentation and classification are crucial to large-scale biomedical imaging, particularly for 3D data, where manual analysis is impractical. Although many methods exist, selecting suitable models and tuning parameters…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 David Exler , Joaquin Eduardo Urrutia Gómez , Martin Krüger , Maike Schliephake , John Jbeily , Mario Vitacolonna , Rüdiger Rudolf , Markus Reischl

This paper proposes the estimation of a mutual shape from a set of different segmentation results using both active contours and information theory. The mutual shape is here defined as a consensus shape estimated from a set of different…

Image and Video Processing · Electrical Eng. & Systems 2021-02-18 S. Jehan-Besson , R. Clouard , C. Tilmant , A. de Cesare , A. Lalande , J. Lebenberg , P. Clarysse , L. Sarry , F. Frouin , M. Garreau

This paper proposes a novel training model based on shape and appearance features for object segmentation in images and videos. Whereas most such models rely on two-dimensional appearance templates or a finite set of descriptors, our…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Martin Mueller , Navdeep Dahiya , Anthony Yezzi

Advances in architectural design, data availability, and compute have driven remarkable progress in semantic segmentation. Yet, these models often rely on relaxed Bayesian assumptions, omitting critical uncertainty information needed for…

Computer Vision and Pattern Recognition · Computer Science 2026-02-19 M. M. A. Valiuddin , R. J. G. van Sloun , C. G. A. Viviers , P. H. N. de With , F. van der Sommen

Shape information is of great importance in many applications. For example, the oil-bearing capacity of sand bodies, the subterranean remnants of ancient rivers, is related to their cross-sectional shapes. The analysis of these shapes is…

Methodology · Statistics 2018-02-28 Thomai Tsiftsi , Ian H. Jermyn , Jochen Einbeck

Parameter inference and uncertainty quantification are important steps when relating mathematical models to real-world observations, and when estimating uncertainty in model predictions. However, methods for doing this can be…

Quantitative Methods · Quantitative Biology 2025-08-27 Michael J. Plank , Matthew J. Simpson

This article presents a general Bayesian learning framework for multi-modal groupwise image registration. The method builds on probabilistic modelling of the image generative process, where the underlying common anatomy and geometric…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Xinzhe Luo , Xin Wang , Linda Shapiro , Chun Yuan , Jianfeng Feng , Xiahai Zhuang

In this paper, we present an approach for modeling bio-tissues that incorporates the variability in properties as part of their characteristics. This is achieved by considering the parameters of the model of a biomaterial to themselves be…

Tissues and Organs · Quantitative Biology 2013-12-11 Srikrishna Doraiswamy , Arun R. Srinivasa