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Computer-assisted synthesis planning aims to help chemists find better reaction pathways faster. Finding viable and short pathways from sugar molecules to value-added chemicals can be modeled as a retrosynthesis planning problem with a…

Other Computer Science · Computer Science 2019-11-19 Peihong Jiang , Hieu Doan , Sandeep Madireddy , Rajeev Surendran Assary , Prasanna Balaprakash

Recent progress has expanded the use of large language models (LLMs) in drug discovery, including synthesis planning. However, objective evaluation of retrosynthesis performance remains limited. Existing benchmarks and metrics typically…

Interactive Recommendation (IR) has gained significant attention recently for its capability to quickly capture dynamic interest and optimize both short and long term objectives. IR agents are typically implemented through Deep…

Information Retrieval · Computer Science 2025-06-17 Jingyu Li , Zhiyong Feng , Dongxiao He , Hongqi Chen , Qinghang Gao , Guoli Wu

Medical image classification is one of the most important tasks for computer-aided diagnosis. Deep learning models, particularly convolutional neural networks, have been successfully used for disease classification from medical images,…

Computer Vision and Pattern Recognition · Computer Science 2023-05-05 Md. Atik Ahamed , Jin Chen , Abdullah-Al-Zubaer Imran

Contrastive self-supervised learning (CSL) with a prototypical regularization has been introduced in learning meaningful representations for downstream tasks that require strong semantic information. However, to optimize CSL with a loss…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Shentong Mo , Zhun Sun , Chao Li

Existing multilingual embedding models often encounter challenges in cross-lingual scenarios due to imbalanced linguistic resources and less consideration of cross-lingual alignment during training. Although standardized contrastive…

Computation and Language · Computer Science 2026-04-15 Seungyoon Lee , Minhyuk Kim , Seongtae Hong , Youngjoon Jang , Dongsuk Oh , Heuiseok Lim

With the recent promising results of contrastive learning in the self-supervised learning paradigm, supervised contrastive learning has successfully extended these contrastive approaches to supervised contexts, outperforming cross-entropy…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Jaewon Kim , Hyukjong Lee , Jooyoung Chang , Sang Min Park

Convolutional neural networks show remarkable results in classification but struggle with learning new things on the fly. We present a novel rehearsal-free approach, where a deep neural network is continually learning new unseen object…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Markus Knauer , Maximilian Denninger , Rudolph Triebel

Identifying enzymes that catalyze target biochemical reactions is a key step in computational enzyme discovery and biocatalyst design. Recent representation-learning methods formulate this problem as enzyme--reaction matching, where paired…

Biomolecules · Quantitative Biology 2026-05-26 Gengmo Zhou , Feng Yu , Wenda Wang , Zhifeng Gao , Guolin Ke , Zhewei Wei , Zhen Wang

The objective of this work is to improve the accuracy of building demand forecasting. This is a more challenging task than grid level forecasting. For the said purpose, we develop a new technique called recurrent transform learning (RTL).…

Machine Learning · Computer Science 2019-12-12 Megha Gupta , Angshul Majumdar

In this paper, we present CLCC, a novel contrastive learning framework for color constancy. Contrastive learning has been applied for learning high-quality visual representations for image classification. One key aspect to yield useful…

Computer Vision and Pattern Recognition · Computer Science 2021-06-10 Yi-Chen Lo , Chia-Che Chang , Hsuan-Chao Chiu , Yu-Hao Huang , Chia-Ping Chen , Yu-Lin Chang , Kevin Jou

Residual learning has recently surfaced as an effective means of constructing very deep neural networks for object recognition. However, current incarnations of residual networks do not allow for the modeling and integration of complex…

Computer Vision and Pattern Recognition · Computer Science 2016-07-21 Brendan Jou , Shih-Fu Chang

Deep representations have shown promising performance when transferred to downstream tasks in a black-box manner. Yet, their inherent lack of interpretability remains a significant challenge, as these features are often opaque to human…

Machine Learning · Computer Science 2024-04-24 Yifei Wang , Qi Zhang , Yaoyu Guo , Yisen Wang

Unsupervised learning has recently made exceptional progress because of the development of more effective contrastive learning methods. However, CNNs are prone to depend on low-level features that humans deem non-semantic. This dependency…

Computer Vision and Pattern Recognition · Computer Science 2022-01-04 Songwei Ge , Shlok Mishra , Haohan Wang , Chun-Liang Li , David Jacobs

While inorganic retrosynthesis planning is essential in the field of chemical science, the application of machine learning in this area has been notably less explored compared to organic retrosynthesis planning. In this paper, we propose…

Machine Learning · Computer Science 2025-10-14 Heewoong Noh , Namkyeong Lee , Gyoung S. Na , Chanyoung Park

The goal of continual learning (CL) is to efficiently update a machine learning model with new data without forgetting previously-learned knowledge. Most widely-used CL methods rely on a rehearsal memory of data points to be reused while…

Machine Learning · Computer Science 2022-03-29 Lukas Balles , Giovanni Zappella , Cédric Archambeau

Multi-label image classification presents a challenging task in many domains, including computer vision and medical imaging. Recent advancements have introduced graph-based and transformer-based methods to improve performance and capture…

Computer Vision and Pattern Recognition · Computer Science 2024-04-15 Ahmad Sajedi , Samir Khaki , Yuri A. Lawryshyn , Konstantinos N. Plataniotis

Deep neural networks suffer from catastrophic forgetting when continually learning new concepts. In this paper, we analyze this problem from a data imbalance point of view. We argue that the imbalance between old task and new task data…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Leyuan Wang , Liuyu Xiang , Yunlong Wang , Huijia Wu , Zhaofeng He

Contrastive representation learning has emerged as a promising technique for continual learning as it can learn representations that are robust to catastrophic forgetting and generalize well to unseen future tasks. Previous work in…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Rouzbeh Meshkinnejad , Jie Mei , Daniel Lizotte , Yalda Mohsenzadeh

Contrastive self-supervised learning (CSL) based on instance discrimination typically attracts positive samples while repelling negatives to learn representations with pre-defined binary self-supervision. However, vanilla CSL is inadequate…

Computer Vision and Pattern Recognition · Computer Science 2022-11-04 Yifei Zhang , Chang Liu , Yu Zhou , Weiping Wang , Qixiang Ye , Xiangyang Ji