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We introduce the notion of corresponding a chemical reaction network to a split network translation, and use this novel process to extend the scope of existing network-based theory for characterizing the steady state set of mass-action…

Dynamical Systems · Mathematics 2021-04-09 Matthew D. Johnston

We study a generic family of nonlinear dynamics on undirected networks generalising linear consensus. We find a compact expression for its equilibrium points in terms of the topology of the network and classify their stability using the…

Dynamical Systems · Mathematics 2021-12-07 Marc Homs-Dones , Karel Devriendt , Renaud Lambiotte

We consider steady states of dynamics that have an underlying network structure. We study how a steady state responds to small perturbations in the network parameters and how this sensitivity is connected to the network structure. We…

Molecular Networks · Quantitative Biology 2023-03-20 Robin Chemnitz

This work concerns the development of deep networks that are certifiably robust to adversarial attacks. Joint robust classification-detection was recently introduced as a certified defense mechanism, where adversarial examples are either…

Computer Vision and Pattern Recognition · Computer Science 2023-05-12 Sina Baharlouei , Fatemeh Sheikholeslami , Meisam Razaviyayn , Zico Kolter

Controlling stochastic reactions networks is a challenging problem with important implications in various fields such as systems and synthetic biology. Various regulation motifs have been discovered or posited over the recent years, the…

Optimization and Control · Mathematics 2018-11-28 Corentin Briat , Mustafa Khammash

Networks with a given degree distribution may be very resilient to one type of failure or attack but not to another. The goal of this work is to determine network design guidelines which maximize the robustness of networks to both random…

Other Condensed Matter · Physics 2009-11-10 G. Paul , T. Tanizawa , S. Havlin , H. E. Stanley

Exact results for product-form stationary distributions of Markov chains are of interest in different fields. In stochastic reaction networks (CRNs), stationary distributions are mostly known in special cases where they are of product-form.…

Probability · Mathematics 2021-12-07 Beatriz Pascual-Escudero , Linard Hoessly

The emergence of autocatalytic sets of molecules seems to have played an important role in the origin of life context. Although the possibility to reproduce this emergence in laboratory has received considerable attention, this is still far…

Adaptation and Self-Organizing Systems · Physics 2015-02-04 Alessandro Filisetti , Marco Villani , Chiara Damiani , Alex Graudenzi , Andrea Roli , Wim Hordijk , Roberto Serra

A decomposition of a chemical reaction network (CRN) is produced by partitioning its set of reactions. The partition induces networks, called subnetworks, that are "smaller" than the given CRN which, at this point, can be called parent…

Molecular Networks · Quantitative Biology 2021-09-15 Lauro L. Fontanil , Eduardo R. Mendoza

We provide a short supplement to the paper "MAPK networks and their capacity for multistationarity due to toric steady states" by P\'erez Mill\'an and Turjanski. We show that the capacity for toric steady states in the three networks…

Dynamical Systems · Mathematics 2014-07-23 Matthew D. Johnston

Previous studies have inferred robust stability of reaction networks by utilizing linear programs or iterative algorithms. Such algorithms become tedious or computationally infeasible for large networks. In addition, they operate like…

Optimization and Control · Mathematics 2023-02-13 M. Ali Al-Radhawi

We investigate the possibility that for any given reaction rate vector $k$ associated with a network $G$, there exists another network $G'$ with a corresponding reaction rate vector that reproduces the mass-action dynamics generated by…

Dynamical Systems · Mathematics 2024-09-10 Samay Kothari , Jiaxin Jin , Abhishek Deshpande

We consider stochastic reaction networks modeled by continuous-time Markov chains. Such reaction networks often contain many reactions, potentially occurring at different time scales, and have unknown parameters (kinetic rates, total…

Probability · Mathematics 2023-02-20 Linard Hoessly , Carsten Wiuf

We study two specific measures of quality of chemical reaction networks, Precision and Sensitivity. The two measures arise in the study of sensory adaptation, in which the reaction network is viewed as an input-output system. Given a step…

Dynamical Systems · Mathematics 2016-01-05 Tom F. A. de Greef , Saeed Masroor , Mark A. Peletier , Rudi A. Pendavingh

We investigate the properties of large random conservative chemical reaction networks composed of elementary reactions endowed with either mass-action or saturating kinetics, assigning kinetic parameters in a thermodynamically-consistent…

Molecular Networks · Quantitative Biology 2014-11-26 Erwan Bigan , Jean-Marc Steyaert , Stéphane Douady

The asymptotic properties of some Markov processes associated to stochastic chemical reaction networks (CRNs) driven by the kinetics of the law of mass action are analyzed. The scaling regime introduced in the paper assumes that the norm of…

Probability · Mathematics 2025-12-18 Lucie Laurence , Philippe Robert

Quantifying the average communication rate (ACR) of a networked event-triggered stochastic control system (NET-SCS) with deterministic thresholds is challenging due to the non-stationary nature of the system's stochastic processes. For a…

Signal Processing · Electrical Eng. & Systems 2024-04-15 Zengjie Zhang , Qingchen Liu , Mohammad H. Mamduhi , Sandra Hirche

We solve a conjecture on multiple nondegenerate steady states, and prove bistability for sequestration networks. More specifically, we prove that for any odd number of species, and for any production factor, the fully open extension of a…

Dynamical Systems · Mathematics 2019-06-04 Xiaoxian Tang , Jie Wang

Chemical reaction networks (CRNs) provide a convenient language for modelling a broad variety of biological systems. These models are commonly studied with respect to the time series they generate in deterministic or stochastic simulations.…

Molecular Networks · Quantitative Biology 2019-07-11 Ozan Kahramanoğulları

Safety-critical perception systems require both reliable uncertainty quantification and principled abstention mechanisms to maintain safety under diverse operational conditions. We present a novel dual-threshold conformalization framework…

Robotics · Computer Science 2025-09-23 Divake Kumar , Nastaran Darabi , Sina Tayebati , Amit Ranjan Trivedi