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This study presents a mathematical model for optimal vaccination strategies in interconnected metropolitan areas, considering commuting patterns. It is a compartmental model with a vaccination rate for each city, acting as a control…

Populations and Evolution · Quantitative Biology 2024-04-29 Lucas Machado Moschen , María Soledad Aronna

We analyze a class of general nonlinear epidemic models with age and space structure, including a nonlocal infection term depending on age and space. After establishing the well-posedness of the state partial differential equation, we…

Optimization and Control · Mathematics 2025-03-11 Behzad Azmi , Nicolas Schlosser

The COVID-19 pandemic highlighted significant challenges in the allocation of vital healthcare resources. Existing epidemiological models, specifically compartmental models, aimed to predict the spread of the COVID-19 virus and its impact…

Physics and Society · Physics 2024-03-14 Hieu Bui , Sandra Eksioglu , Ruben Proano

An urgent problem in controlling COVID-19 spreading is to understand the role of undocumented infection. We develop a five-state model for COVID-19, taking into account the unique features of the novel coronavirus, with key parameters…

Populations and Evolution · Quantitative Biology 2020-03-27 Yong-Shang Long , Zheng-Meng Zhai , Li-Lei Han , Jie Kang , Yi-Lin Li , Zhao-Hua Lin , Lang Zeng , Da-Yu Wu , Chang-Qing Hao , Ming Tang , Zonghua Liu , Ying-Cheng Lai

We consider the $SEIRS$ epidemiology model with such features of the COVID-19 outbreak as: abundance of unidentified infected individuals, limited time of immunity and a possibility of vaccination. Within a compartmental realization of this…

Populations and Evolution · Quantitative Biology 2021-12-07 Jaroslav Ilnytskyi , Taras Patsahan

This technical report describes a dynamic causal model of the spread of coronavirus through a population. The model is based upon ensemble or population dynamics that generate outcomes, like new cases and deaths over time. The purpose of…

As the COVID19 spreads across the world, prevention measures are becoming the essential weapons to combat the pandemic in the period of crisis. The lockdown measure is the most controversial one as it imposes an overwhelming impact on our…

Physics and Society · Physics 2021-02-12 Yuting Fu , Haitao Xiang , Hanqing Jin , Ning Wang

We explore the inclusion of vaccination in compartmental epidemiological models concerning the delta and omicron variants of the SARS-CoV-2 virus that caused the COVID-19 pandemic. We expand on our earlier compartmental-model work by…

Populations and Evolution · Quantitative Biology 2023-04-24 J. Cuevas-Maraver , P. G. Kevrekidis , Q. Y. Chen , G. A. Kevrekidis , Y. Drossinos

In this paper, we provide insights on how much testing and social distancing is required to control COVID-19. To this end, we develop a compartmental model that accounts for key aspects of the disease: 1) incubation time, 2) age-dependent…

Optimization and Control · Mathematics 2020-11-04 Sara Grundel , Stefan Heyder , Thomas Hotz , Tobias K. S. Ritschel , Philipp Sauerteig , Karl Worthmann

The recent COVID-19 pandemic has shown that when the reproduction number is high and there are no proper measurements in place, the number of infected people can increase dramatically in a short time, producing a phenomenon that many…

Populations and Evolution · Quantitative Biology 2022-09-20 Jonathan A. Chávez Casillas

We consider a susceptible, infected, and recovered infectious disease model which incorporates a vaccination rate. In particular, we study the problem of choosing the vaccination rate in order to reduce the number of infected individuals to…

Analysis of PDEs · Mathematics 2021-08-30 Ryan Hynd , Dennis Ikpe , Terrance Pendleton

Human civilization is experiencing a critical situation that presents itself for a new coronavirus disease 2019 (COVID-19). This virus emerged in late December 2019 in Wuhan city, Hubei, China. The grim fact of COVID-19 is, it is highly…

Computers and Society · Computer Science 2020-08-25 Bikash Chandra Singh , Zulfikar Alom , Mohammad Muntasir Rahman , Mrinal Kanti Baowaly , Mohammad Abdul Azim

This paper presents the assessment of time-dependent national-level restrictions and control actions and their effects in fighting the COVID-19 pandemic. By analysing the transmission dynamics during the first wave of COVID-19 in the…

Populations and Evolution · Quantitative Biology 2021-02-04 Ton Duc Do , Meei Mei Gui , Kok Yew Ng

In the context of epidemiology, policies for disease control are often devised through a mixture of intuition and brute-force, whereby the set of logically conceivable policies is narrowed down to a small family described by a few…

Populations and Evolution · Quantitative Biology 2021-10-04 Miguel Navascues , Costantino Budroni , Yelena Guryanova

Compartmental models have long served as important tools in mathematical epidemiology, with their usefulness highlighted by the recent COVID-19 pandemic. However, most of the classical models fail to account for certain features of this…

Dynamical Systems · Mathematics 2023-08-21 Monique Chyba , Taylor Klotz , Yuriy Mileyko , Corey Shanbrom

Background: The ongoing COVID-19 epidemic dilated rapidly throughout India. To end the global COVID-19 pandemic major behavioral, social distancing, contact tracing, and state interventions has been undertaken to reduce the outbreak and…

Populations and Evolution · Quantitative Biology 2020-07-15 Kankan Sarkar , Subhas Khajanchi

The waning of immunity after recovery or vaccination is a major factor accounting for the severity and prolonged duration of an array of epidemics, ranging from COVID-19 to diphtheria and pertussis. To study the effectiveness of different…

Dynamical Systems · Mathematics 2023-02-01 Shoshana Elgart

With COVID-19 having emerged as the most widespread human pandemic disease in a century, the need to control its spread to avoid massive loss of life became more than necessary, and extremely fast. Several vaccines were developed and the…

This work presents a novel Model Predictive Control (MPC) approach to develop an optimal age-structured vaccination strategy for the containment of COVID-19 in Wallonia, Belgium. The proposed MPC framework is designed to minimize deaths,…

Optimization and Control · Mathematics 2026-02-17 Candy Sonveaux , Morgane Dumont , Mirko Fiacchini , Mohamad Ajami

As new COVID-19 variants continue to emerge globally, we develop an SISI-type mathematical model to determine whether the transmission risks arising when such a new variant enters Indonesia can be mitigated by solely accelerating the…

Dynamical Systems · Mathematics 2023-09-04 Benny Yong , Jonathan Hoseana , Livia Owen