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When applying multi-instance learning (MIL) to make predictions for bags of instances, the prediction accuracy of an instance often depends on not only the instance itself but also its context in the corresponding bag. From the viewpoint of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Tiancheng Lin , Hongteng Xu , Canqian Yang , Yi Xu

Due to the lack of fine-grained annotation guidance, current Multiple Instance Learning (MIL) struggles to establish a robust causal relationship between Whole Slide Image (WSI) diagnosis and evidence sub-images, just like fully supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Tianhang Nan , Yong Ding , Hao Quan , Deliang Li , Lisha Li , Guanghong Zhao , Xiaoyu Cui

Accurate risk assessment in lung cancer screening is critical for enabling early cancer detection and minimizing unnecessary invasive procedures. The Lung CT Screening Reporting and Data System (Lung-RADS) has been widely used as the…

Machine Learning · Computer Science 2025-09-09 Chuang Niu , Ge Wang

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret…

Computer Vision and Pattern Recognition · Computer Science 2020-04-27 Bo Liu , Wenhao Chi , Xinran Li , Peng Li , Wenhua Liang , Haiping Liu , Wei Wang , Jianxing He

Lung cancer has been one of the major threats across the world with the highest mortalities. Computer-aided detection (CAD) can help in early detection and thus can help increase the survival rate. Accurate lung parenchyma segmentation (to…

Image and Video Processing · Electrical Eng. & Systems 2025-09-18 Muhammad Abdullah , Furqan Shaukat

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

With the development of computer technology, various models have emerged in artificial intelligence. The transformer model has been applied to the field of computer vision (CV) after its success in natural language processing (NLP).…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Ruina Sun , Yuexin Pang

Due to the high heterogeneity and clinical characteristics of cancer, there are significant differences in multi-omic data and clinical characteristics among different cancer subtypes. Therefore, accurate classification of cancer subtypes…

Quantitative Methods · Quantitative Biology 2023-08-23 Liangrui Pan , Dazheng Liu , Zhichao Feng , Wenjuan Liu , Shaoliang Peng

Lung cancer remains one of the most prevalent and fatal diseases worldwide, demanding accurate and timely diagnosis and treatment. Recent advancements in large AI models have significantly enhanced medical image understanding and clinical…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Jiachen Zhong , Yiting Wang , Di Zhu , Ziwei Wang

Lung cancer classification in screening computed tomography (CT) scans is one of the most crucial tasks for early detection of this disease. Many lives can be saved if we are able to accurately classify malignant/cancerous lung nodules.…

Image and Video Processing · Electrical Eng. & Systems 2021-09-20 Mundher Al-Shabi , Kelvin Shak , Maxine Tan

Lung cancer is the leading cause of cancer deaths. Early detection through low-dose computed tomography (CT) screening has been shown to significantly reduce mortality but suffers from a high false positive rate that leads to unnecessary…

Image and Video Processing · Electrical Eng. & Systems 2019-06-04 Jason L. Causey , Yuanfang Guan , Wei Dong , Karl Walker , Jake A. Qualls , Fred Prior , Xiuzhen Huang

Lung cancer is a leading cause of death worldwide and early screening is critical for improving survival outcomes. In clinical practice, the contextual structure of nodules and the accumulated experience of radiologists are the two core…

Image and Video Processing · Electrical Eng. & Systems 2023-07-21 Jianpeng Zhang , Xianghua Ye , Jianfeng Zhang , Yuxing Tang , Minfeng Xu , Jianfei Guo , Xin Chen , Zaiyi Liu , Jingren Zhou , Le Lu , Ling Zhang

Multiple Instance Learning (MIL) has garnered widespread attention in the field of Whole Slide Image (WSI) classification as it replaces pixel-level manual annotation with diagnostic reports as labels, significantly reducing labor costs.…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Tianhang Nan , Hao Quan , Yong Ding , Xingyu Li , Kai Yang , Xiaoyu Cui

Survival prediction is a crucial task associated with cancer diagnosis and treatment planning. This paper presents a novel approach to survival prediction by harnessing comprehensive information from CT and PET scans, along with associated…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Aiman Farooq , Deepak Mishra , Santanu Chaudhury

Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Thiziri Nait Saada , Valentina Di Proietto , Benoit Schmauch , Katharina Von Loga , Lucas Fidon

The most common type of lung cancer, lung adenocarcinoma (LUAD), has been increasingly detected since the advent of low-dose computed tomography screening technology. In clinical practice, pre-invasive LUAD (Pre-IAs) should only require…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Jing Zhou , Xiaotong Fu , Xirong Li , Ying Ji

Colorectal cancer is one of the most common and lethal cancers and colorectal cancer liver metastases (CRLM) is the major cause of death in patients with colorectal cancer. Multifocality occurs frequently in CRLM, but is relatively…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Jianan Chen , Helen M. C. Cheung , Laurent Milot , Anne L. Martel

In the medical field, accurate diagnosis of lung cancer is crucial for treatment. Traditional manual analysis methods have significant limitations in terms of accuracy and efficiency. To address this issue, this paper proposes a deep…

Image and Video Processing · Electrical Eng. & Systems 2025-01-10 Ziyang Gao , Yong Tian , Shih-Chi Lin , Junghua Lin

Lung cancer is a leading cause of cancer-related deaths worldwide, and early detection is crucial for improving patient outcomes. Nevertheless, early diagnosis of cancer is a major challenge, particularly in low-resource settings where…

Image and Video Processing · Electrical Eng. & Systems 2026-02-12 Samiul Based Shuvo , Tasnia Binte Mamun
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