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Time to an event of interest over a lifetime is a central measure of the clinical benefit of an intervention used in a health technology assessment (HTA). Within the same trial, multiple end-points may also be considered. For example,…

Applications · Statistics 2026-01-13 Nathan Green , Murat Kurt , Andriy Moshyk , James Larkin , Gianluca Baio

Despite the importance of emphasizing the right psychotherapy treatment for an individual patient, assessing the outcome of the therapy session is equally crucial. Evidence showed that continuous monitoring patient's progress can…

Computation and Language · Computer Science 2022-12-19 Noor Fazilla Abd Yusof , Chenghua Lin

When dealing with right-censored data, where some outcomes are missing due to a limited observation period, survival analysis -- known as time-to-event analysis -- focuses on predicting the time until an event of interest occurs. Multiple…

Machine Learning · Statistics 2024-10-23 Julie Alberge , Vincent Maladière , Olivier Grisel , Judith Abécassis , Gaël Varoquaux

Hazard ratios are ubiquitously used in time to event analysis to quantify treatment effects. Although hazard ratios are invaluable for hypothesis testing, other measures of association, both relative and absolute, may be used to fully…

Methodology · Statistics 2020-11-02 Federico Ambrogi , Simona Iacobelli , Per Kragh Andersen

The mean survival is the key ingredient of the decision process in several applications, notably in health economic evaluations. It is defined as the area under the complete survival curve, thus necessitating extrapolation of the observed…

Applications · Statistics 2026-03-10 Anastasios Apsemidis , Nikolaos Demiris

Benchmarking is generally accepted as an important element in demonstrating the correctness of computer simulations. In the modern sense, a benchmark is a computer simulation result that has evidence of correctness, is accompanied by…

Plasma Physics · Physics 2015-06-12 M. M. Turner , A. Derzsi , Z. Donko , D. Eremin , S. J. Kelly , T. Lafleur , T. Mussenbrock

In clinical trials, multiple outcomes of different priorities commonly occur as the patient's response may not be adequately characterized by a single outcome. Win statistics are appealing summary measures for between-group difference at…

Methodology · Statistics 2025-06-04 Ying Cui , Bo Huang , Gaohong Dong , Ryuji Uozumi , Lu Tian

Causal discovery can be a powerful tool for investigating causality when a system can be observed but is inaccessible to experiments in practice. Despite this, it is rarely used in any scientific or medical fields. One of the major hurdles…

Machine Learning · Statistics 2019-10-07 Erich Kummerfeld , Alexander Rix

Progress of machine learning in critical care has been difficult to track, in part due to absence of public benchmarks. Other fields of research (such as computer vision and natural language processing) have established various competitions…

Machine Learning · Computer Science 2023-07-19 Seyedmostafa Sheikhalishahi , Vevake Balaraman , Venet Osmani

This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much…

Methodology · Statistics 2021-12-22 Tzu-Jung Huang , Alex Luedtke , Ian W. McKeague

Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown)…

Machine Learning · Statistics 2020-03-03 Paidamoyo Chapfuwa , Chunyuan Li , Nikhil Mehta , Lawrence Carin , Ricardo Henao

There is a growing trend of applying machine learning methods to medical datasets in order to predict patients' future status. Although some of these methods achieve high performance, challenges still exist in comparing and evaluating…

Medical Physics · Physics 2020-03-25 Yiran Li , Takanori Fujiwara , Yong K. Choi , Katherine K. Kim , Kwan-Liu Ma

Chronic diseases are long-lasting conditions that require lifelong medical attention. Using big EMR data, we have developed early disease risk prediction models for five common chronic diseases: diabetes, hypertension, CKD, COPD, and…

Machine Learning · Computer Science 2026-03-13 Shaheer Ahmad Khan , Muhammad Usamah Shahid , Muddassar Farooq

Inferring treatment effects on a survival time outcome based on data from an observational study is challenging due to the presence of censoring and possible confounding. An additional challenge occurs when a unit's treatment affects the…

Methodology · Statistics 2025-08-13 Chanhwa Lee , Donglin Zeng , Michael Emch , John D. Clemens , Michael G. Hudgens

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Survival analysis encompasses a broad range of methods for analyzing time-to-event data, with one key objective being the comparison of survival curves across groups. Traditional approaches for identifying clusters of survival curves often…

Methodology · Statistics 2025-12-19 Nora M. Villanueva , Marta Sestelo , Luis Meira-Machado

To address the challenge of utilizing patient data from other organ transplant centers (source cohorts) to improve survival time estimation and inference for a target center (target cohort) with limited samples and strict data-sharing…

Methodology · Statistics 2025-03-25 Hua Liu , Jiaqi Men , Shouxia Wang , Jinhong You , Jiguo Cao

Reliable uncertainty quantification is essential in survival prediction, particularly in clinical settings where erroneous decisions carry high risk. Conformal prediction has attracted substantial attention as it offers a model-agnostic…

Methodology · Statistics 2025-12-04 Jaeyoung Shin , Chi Hyun Lee , Sangwook Kang

Empirical and LLM-based research in model-driven engineering increasingly relies on datasets of software models, for instance, to train or evaluate machine learning techniques for modeling support. These datasets have a significant impact…

Software Engineering · Computer Science 2026-03-06 Philipp-Lorenz Glaser , Lola Burgueño , Dominik Bork

Scoring rules are an established way of comparing predictive performances across model classes. In the context of survival analysis, they require adaptation in order to accommodate censoring. This work investigates using scoring rules for…

Machine Learning · Computer Science 2024-11-14 Philipp Kopper , David Rügamer , Raphael Sonabend , Bernd Bischl , Andreas Bender