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Dose-finding trials are a key component of the drug development process and rely on a statistical design to help inform dosing decisions. Triallists wishing to choose a design require knowledge of operating characteristics of competing…

Computation · Statistics 2025-03-11 Michael Sweeting , Daniel Slade , Dan Jackson , Kristian Brock

This draft report summarizes and details the findings, results, and recommendations derived from the ASCR/HEP Exascale Requirements Review meeting held in June, 2015. The main conclusions are as follows. 1) Larger, more capable computing…

In this study, we provided a scheduling procedure which is a combination of machine learning and mathematical programming that minimizes the waiting time of higher priority outpatients. Outpatients who request for appointment in healthcare…

Signal Processing · Electrical Eng. & Systems 2024-01-02 Niloofar Yousefi , Farhad Hasankhani , Mahsa Kiani , Nooshin Yousefi

The increasing integration of renewable energy into the power grid has highlighted the critical importance of demand-side flexibility. Among flexible loads, heating, ventilation, and air-conditioning (HVAC) systems are particularly…

Systems and Control · Electrical Eng. & Systems 2025-08-12 Xinlei Zhou , Han Du , Emily W. Yap , Wanbin Dou , Mingyang Huang , Zhenjun Ma

Due to the diversity of fuel cycle simulator modeling assumptions, direct comparison and benchmarking can be difficult. In 2012 the Organisation for Economic Co-operation and Development completed a benchmark study that is perhaps the most…

Computational Engineering, Finance, and Science · Computer Science 2016-05-05 Robert W. Carlsen , Paul P. H. Wilson

The increasing reliance on dynamic pricing models, such as spot instances, in public cloud environments presents new challenges for workload scheduling and reliability. While these models offer cost advantages, they introduce volatility and…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-25 Christoph Goldgruber , Benedikt Pittl , Erich Schikuta

The employment of micro-simulation (agent-based) tools in the phase of design of public and private spaces and facilities and for the definition of transport schemes that impact on pedestrian flows, thanks to their achieved accuracy and…

Multiagent Systems · Computer Science 2014-07-21 Mizar Luca Federici , Lorenza Manenti , Sara Manzoni

We present predictive tools to calculate the number of ambulances needed according to demand of entrance calls and time of service. Our analysis discriminates between emergency and non-urgent calls. First, we consider the nonstationary…

Applications · Statistics 2025-12-11 Pedro A. Pury

We present a resource-planning tool for hospitals under special consideration of the COVID-19 pandemic, called babsim.hospital. It provides many advantages for crisis teams, e.g., comparison with their own local planning, simulation of…

Applications · Statistics 2020-12-15 Thomas Bartz-Beielstein , Frederik Rehbach , Olaf Mersmann , Eva Bartz

This paper presents a simulation approach to enhance the performance of heuristics for multi-project scheduling. Unlike other heuristics available in the literature that use only one priority criterion for resource allocation, this paper…

Portfolio Management · Quantitative Finance 2024-06-05 Pablo Alvarez-Campana , Felix Villafanez , Fernando Acebes , David Poza

Observational data in medicine arise as a result of the complex interaction between patients and the healthcare system. The sampling process is often highly irregular and itself constitutes an informative process. When using such data to…

Machine Learning · Computer Science 2022-05-27 Vincent Jeanselme , Glen Martin , Niels Peek , Matthew Sperrin , Brian Tom , Jessica Barrett

Over the past decade, there has been a severe staffing shortage in mental healthcare, exacerbated by increased demand for mental health services due to COVID-19. This demand is projected to increase over the next decade or so, necessitating…

Applications · Statistics 2025-03-10 Harsha Chamara Hewage , Bahman Rostami-Tabar

Three-dimensional cardiovascular fluid dynamics simulations typically require computation of several cardiac cycles before they reach a periodic solution, rendering them computationally expensive. Furthermore, there is currently no…

Computational Engineering, Finance, and Science · Computer Science 2021-06-28 Martin R. Pfaller , Jonathan Pham , Nathan M. Wilson , David W. Parker , Alison L. Marsden

Objective: Machine learning algorithms are now widely used in predicting acute events for clinical applications. While most of such prediction applications are developed to predict the risk of a particular acute event at one hospital, few…

The unknown parameters of simulation models often need to be calibrated using observed data. When simulation models are expensive, calibration is usually carried out with an emulator. The effectiveness of the calibration process can be…

Computation · Statistics 2024-12-03 Özge Sürer , Stefan M. Wild

Shift scheduling impacts healthcare workers' well-being because it sets the frame for their social life and recreational activities. Since it is complex and time-consuming, it has become a target for automation. However, existing systems…

Human-Computer Interaction · Computer Science 2021-02-15 Alarith Uhde , Matthias Laschke , Marc Hassenzahl

We consider the problem of scheduling elective surgeries in a Children's Hospital, where disruptions due to emergencies and no-shows may arise. We account for two features that occur in many pediatric settings: i) that it is not uncommon…

Optimization and Control · Mathematics 2024-08-23 Martina Doneda , Gloria Pelizzo , Sara Costanzo , Giuliana Carello

Increasing data volumes in scientific experiments necessitate the use of high-performance computing (HPC) resources for data analysis. In many scientific fields, the data generated from scientific instruments and supercomputer simulations…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-03-25 Sam Nickolay , Eun-Sung Jung , Rajkumar Kettimuthu , Ian Foster

Efficient management of spare parts inventory is crucial in the automotive aftermarket, where demand is highly intermittent and uncertainty drives substantial cost and service risks. Forecasting is therefore central, but the quality of…

Artificial Intelligence · Computer Science 2026-02-03 So Fukuhara , Abdallah Alabdallah , Nuwan Gunasekara , Slawomir Nowaczyk

Nursing homes (NHs) are critical healthcare infrastructures for caring frail older adults with 24/7 formal care and personal assistance. Adequate NH resource planning is of great importance to ensure desired quality of care and resident…

Systems and Control · Electrical Eng. & Systems 2021-02-04 Xuxue Sun , Nazmus Sakib , Nan Kong , Hongdao Meng , Kathryn Hyer , Chris Masterson , Mingyang Li