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Machine Learning (ML) techniques are revolutionizing the way to perform efficient materials modeling. Nevertheless, not all the ML approaches allow for the understanding of microscopic mechanisms at play in different phenomena. To address…

Materials Science · Physics 2022-06-22 Udaykumar Gajera , Loriano Storchi , Danila Amoroso , Francesco Delodovici , Silvia Picozzi

We show how machine learning techniques based on Bayesian inference can be used to reach new levels of realism in the computer simulation of molecular materials, focusing here on water. We train our machine-learning algorithm using…

Materials Science · Physics 2013-02-25 Albert P. Bartok , Michael J. Gillan , Frederick R. Manby , Gabor Csanyi

The essence of a chemical reaction lies in the redistribution and reorganization of electrons, which is often manifested through electron transfer or the migration of electron pairs. These changes are inherently discrete and abrupt in the…

Machine Learning · Computer Science 2025-07-14 Haitao Lin , Junjie Wang , Zhifeng Gao , Xiaohong Ji , Rong Zhu , Linfeng Zhang , Guolin Ke , Weinan E

Accurately predicting chemical reaction outcomes and potential byproducts is a fundamental task of modern chemistry, enabling the efficient design of synthetic pathways and driving progress in chemical science. Reaction mechanism, which…

Chemical Physics · Physics 2025-03-14 Shuan Chen , Kye Sung Park , Taewan Kim , Sunkyu Han , Yousung Jung

Deep learning-based reaction predictors have undergone significant architectural evolution. However, their reliance on reactions from the US Patent Office results in a lack of interpretable predictions and limited generalization capability…

Identifying the mutations that drive cancer growth is key in clinical decision making and precision oncology. As driver mutations confer selective advantage and thus have an increased likelihood of occurrence, frequency-based statistical…

Genomics · Quantitative Biology 2021-05-04 Adnan Akbar , Andrey Solovyev , John W Cassidy , Nirmesh Patel , Harry W Clifford

Modeling of turbulent combustion system requires modeling the underlying chemistry and the turbulent flow. Solving both systems simultaneously is computationally prohibitive. Instead, given the difference in scales at which the two…

Machine Learning · Computer Science 2022-11-14 Amol Salunkhe , Dwyer Deighan , Paul Desjardin , Varun Chandola

Natural products, as metabolites from microorganisms, animals, or plants, exhibit diverse biological activities, making them crucial for drug discovery. Nowadays, existing deep learning methods for natural products research primarily rely…

Quantitative Methods · Quantitative Biology 2026-05-11 Yuheng Ding , Bo Qiang , Shaoning Li , Yiran Zhou , Jie Yu , Qi Li , Cheng Shi , Liangren Zhang , Yusong Wang , Nanning Zheng , Zhenming Liu

A modification of the Random Forest algorithm for the categorization of traffic situations is introduced in this paper. The procedure yields an unsupervised machine learning method. The algorithm generates a proximity matrix which contains…

Signal Processing · Electrical Eng. & Systems 2020-04-08 Friedrich Kruber , Jonas Wurst , Michael Botsch

Relevant to broad applied fields and natural processes, interfacial ionic hydrates has been widely studied by ultrahigh-resolution atomic force microscopy (AFM). However, the complex relationship between AFM signal and the investigated…

Mesoscale and Nanoscale Physics · Physics 2023-04-25 Binze Tang , Yizhi Song , Mian Qin , Ye Tian , Duanyun Cao , Zhen Wei Wu , Ying Jiang , Limei Xu

Machine learning techniques are powerful tools for construction of emulators for complex systems. We explore different machine learning methods and conceptual methodologies, ranging from functional approximations to dynamical…

Dynamical Systems · Mathematics 2021-01-01 Hannah Lu , Dinara Ermakova , Haruko Murakami Wainwright , Liange Zheng , Daniel M. Tartakovsky

When dense granular gases are continuously excited under microgravity conditions, spatial inhomogeneities of the particle number density can emerge. A significant share of particles may collect in strongly overpopulated regions, called…

Soft Condensed Matter · Physics 2025-06-19 Sai Preetham Sata , Ralf Stannarius , Benjamin Noack , Dmitry Puzyrev

In many astrophysical applications, the cost of solving a chemical network represented by a system of ordinary differential equations (ODEs) grows significantly with the size of the network, and can often represent a significant…

Instrumentation and Methods for Astrophysics · Physics 2022-12-21 T. Grassi , F. Nauman , J. P. Ramsey , S. Bovino , G. Picogna , B. Ercolano

Machine learning-based models to predict product state distributions from a distribution of reactant conditions for atom-diatom collisions are presented and quantitatively tested. The models are based on function-, kernel- and grid-based…

Chemical Physics · Physics 2020-11-06 Julian Arnold , Debasish Koner , Silvan Käser , Narendra Singh , Raymond J. Bemish , Markus Meuwly

Recently, decision trees (DT) have been used as an explainable representation of controllers (a.k.a. strategies, policies, schedulers). Although they are often very efficient and produce small and understandable controllers for discrete…

Machine Learning · Computer Science 2022-08-30 Florian Jüngermann , Jan Křetínský , Maximilian Weininger

The dynamics of water molecules plays a vital role in understanding water. We combined computer simulation and deep learning to study the dynamics of H-bonds between water molecules. Based on ab initio molecular dynamics simulations and a…

Disordered Systems and Neural Networks · Physics 2021-10-19 Jie Huang , Gang Huang , Shiben Li

The classical method of determining the atomic structure of complex molecules by analyzing diffraction patterns is currently undergoing drastic developments. Modern techniques for producing extremely bright and coherent X-ray lasers allow a…

Biomolecules · Quantitative Biology 2015-10-12 Tomas Ekeberg , Stefan Engblom , Jing Liu

The response of proteins to chemical reactions or impulsive excitation that occurs within the molecule has fascinated chemists for decades. In recent years ultrafast X-ray studies have provided ever more detailed information about the…

Biological Physics · Physics 2018-05-11 David M. Leitner , Takahisa Yamato

We propose an unsupervised learning methodology with descriptors based on Topological Data Analysis (TDA) concepts to describe the local structural properties of materials at the atomic scale. Based only on atomic positions and without a…

Disordered Systems and Neural Networks · Physics 2022-04-20 Sébastien Becker , Emilie Devijver , Rémi Molinier , Noël Jakse

Accurate identification of chemical species and reaction pathways from molecular dynamics (MD) trajectories is a prerequisite for deriving predictive chemical-kinetic models and for mechanistic discovery in reactive systems. However,…

Computational Physics · Physics 2026-01-14 Raj Maddipati , Dhruthi Boddapati , Elangannan Arunan , Phani Motamarri , Konduri Aditya