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For living beings, survival depends on effective regulation of internal physiological states through motivated behaviors. In this perspective we propose that Homeostatically Regulated Reinforcement Learning (HRRL) as a framework to describe…

Neurons and Cognition · Quantitative Biology 2025-07-08 Naoto Yoshida , Henning Sprekeler , Boris Gutkin

Neurons rely on two interdependent mechanisms, homeostasis and neuromodulation, to maintain robust and adaptable functionality. Calcium homeostasis stabilizes neuronal activity by adjusting ionic conductances, whereas neuromodulation…

Neurons and Cognition · Quantitative Biology 2026-05-13 Arthur Fyon , Guillaume Drion

In vitro and in vivo spiking activity clearly differ. Whereas networks in vitro develop strong bursts separated by periods of very little spiking activity, in vivo cortical networks show continuous activity. This is puzzling considering…

Neurons and Cognition · Quantitative Biology 2018-07-24 Johannes Zierenberg , Jens Wilting , Viola Priesemann

In the mammalian nervous system, various synaptic plasticity rules act, either individually or synergistically, and over wide-ranging timescales to dictate the processes that enable learning and memory formation. To mimic biological…

Disordered Systems and Neural Networks · Physics 2021-06-11 Syed Ghazi Sarwat , Benedikt Kersting , Timoleon Moraitis , Vara Prasad Jonnalagadda , Abu Sebastian

We describe a mechanism for biological learning and adaptation based on two simple principles: (I) Neuronal activity propagates only through the network's strongest synaptic connections (extremal dynamics), and (II) The strengths of active…

Disordered Systems and Neural Networks · Physics 2009-10-31 Per Bak , Dante R Chialvo

Behavioral changes in animals and humans, as a consequence of an error or a verbal instruction, can be extremely rapid. Improvement in behavioral performances are usually associated in machine learning and reinforcement learning to synaptic…

Neurons and Cognition · Quantitative Biology 2025-03-12 Cristiano Capone , Luca Falorsi

We introduce a novel, biologically plausible local learning rule that provably increases the robustness of neural dynamics to noise in nonlinear recurrent neural networks with homogeneous nonlinearities. Our learning rule achieves higher…

Neurons and Cognition · Quantitative Biology 2022-10-12 Christopher H. Stock , Sarah E. Harvey , Samuel A. Ocko , Surya Ganguli

The neural activity of the human brain is dominated by self-sustained activities. External sensory stimuli influence this autonomous activity but they do not drive the brain directly. Most standard artificial neural network models are…

Neurons and Cognition · Quantitative Biology 2009-11-13 Claudius Gros

Human learning is a complex phenomenon requiring flexibility to adapt existing brain function and precision in selecting new neurophysiological activities to drive desired behavior. These two attributes -- flexibility and selection -- must…

Neurons and Cognition · Quantitative Biology 2013-06-28 Danielle S. Bassett , Nicholas F. Wymbs , Mason A. Porter , Peter J. Mucha , Jean M. Carlson , Scott T. Grafton

This paper introduces a biomathematical model designed to describe the internal dynamics of dream formation and spontaneous cognitive processes. The model incorporates neurocognitive factors such as dissatisfaction, acceptance, forgetting,…

Neurons and Cognition · Quantitative Biology 2025-05-12 Shirmohammad Tavangari , Sajjad Janfaza , Zahra Shakarami , Aref Yelghi

We consider artificial neurons which will update their weight coefficients with an internal rule based on backpropagation, rather than using it as an external training procedure. To achieve this we include the backpropagation error estimate…

Neural and Evolutionary Computing · Computer Science 2018-08-07 M. N. Nazarov

The availability of large-scale neuronal population datasets necessitates new methods to model population dynamics and extract interpretable, scientifically translatable insights. Existing deep learning methods often overlook the biological…

Neurons and Cognition · Quantitative Biology 2024-11-14 Parsa Delavari , Ipek Oruc , Timothy H Murphy

Biological neurons exhibit remarkable intelligence: they maintain internal states, communicate selectively with other neurons, and self-organize into complex graphs rather than rigid hierarchical layers. What if artificial intelligence…

Machine Learning · Computer Science 2025-12-01 Antoine Salomon

Brains remain unrivaled in their ability to recognize and generate complex spatiotemporal patterns. While AI is able to reproduce some of these capabilities, deep learning algorithms remain largely at odds with our current understanding of…

Neurons and Cognition · Quantitative Biology 2026-03-13 Simon Brandt , Paul Haider , Walter Senn , Federico Benitez , Mihai A. Petrovici

Biological neurons have adaptive nature and perform complex computations involving the filtering of redundant information. However, most common neural cell models, including biologically plausible, such as Hodgkin-Huxley or Izhikevich, do…

Neurons and Cognition · Quantitative Biology 2021-06-22 Oleg Nikitin , Olga Lukyanova , Alex Kunin

A key challenge for AI is to build embodied systems that operate in dynamically changing environments. Such systems must adapt to changing task contexts and learn continuously. Although standard deep learning systems achieve state of the…

Neural and Evolutionary Computing · Computer Science 2022-04-26 Abhiram Iyer , Karan Grewal , Akash Velu , Lucas Oliveira Souza , Jeremy Forest , Subutai Ahmad

Continual learning of deep neural networks is a key requirement for scaling them up to more complex applicative scenarios and for achieving real lifelong learning of these architectures. Previous approaches to the problem have considered…

Machine Learning · Computer Science 2020-06-25 Jary Pomponi , Simone Scardapane , Vincenzo Lomonaco , Aurelio Uncini

Spiking Neural Networks (SNNs) can do inference with low power consumption due to their spike sparsity. ANN-SNN conversion is an efficient way to achieve deep SNNs by converting well-trained Artificial Neural Networks (ANNs). However, the…

Neural and Evolutionary Computing · Computer Science 2023-03-24 Xiang He , Yang Li , Dongcheng Zhao , Qingqun Kong , Yi Zeng

Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the…

Neurons and Cognition · Quantitative Biology 2025-11-20 Nicoas Zucchet , Qianqian Feng , Axel Laborieux , Friedemann Zenke , Walter Senn , João Sacramento

In this paper we investigate the homeostatic mechanism in two biologically motivated models: intracellular copper regulation and self immune recognition. The analysis is based on the notions of infinitesimal homeostasis and near-perfect…

Molecular Networks · Quantitative Biology 2022-02-24 Pedro P. A. Cardoso de Andrade , João L. O. Madeira , Fernando Antoneli
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