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Spontaneous structural rearrangements play a central role in the organization and function of complex biomolecular systems. In principle, physics-based computer simulations like Molecular Dynamics (MD) enable us to investigate these…

Quantum Physics · Physics 2026-03-19 Danial Ghamari , Philipp Hauke , Roberto Covino , Pietro Faccioli

Density matrix electronic structure theory is used in many quantum chemistry methods to "alleviate" the computational cost that arises from directly using wave functions. Although density matrix based methods are computationally more…

Quantum annealing has emerged as a powerful platform for simulating and optimizing classical and quantum Ising models. Quantum annealers, like other quantum and/or analog computing devices, are susceptible to nonidealities including…

Quantum Physics · Physics 2024-10-15 Kevin Chern , Kelly Boothby , Jack Raymond , Pau Farré , Andrew D. King

In silico de novo design can drastically cut the costs and time of drug development. In particular, a key advantage of bottom-up physics-based approaches is their independence from training datasets, unlike generative models. However, they…

Quantum Physics · Physics 2025-12-01 Lars Meuser , Alexandros Patsilinakos , Pietro Faccioli

We propose a novel method for reducing the number of variables in quadratic unconstrained binary optimization problems, using a quantum annealer (or any sampler) to fix the value of a large portion of the variables to values that have a…

Quantum Physics · Physics 2017-09-26 Hamed Karimi , Gili Rosenberg

Discrete combinatorial optimization consists in finding the optimal configuration that minimizes a given discrete objective function. An interpretation of such a function as the energy of a classical system allows us to reduce the…

Quantum Physics · Physics 2015-06-22 Sergio Boixo , Gerardo Ortiz , Rolando Somma

To increase efficiency in automotive manufacturing, newly produced vehicles can move autonomously from the production line to the distribution area. This requires an optimal placement of sensors to ensure full coverage while minimizing the…

Emerging Technologies · Computer Science 2025-07-23 Nico Kraus , Marvin Erdmann , Alexander Kuzmany , Daniel Porawski , Jonas Stein

The presence of a bias field, encoding some information about the target state, can enhance the performance of quantum optimization methods. Here we investigate the effect of such a bias field on the outcome of quantum annealing sampling,…

Quantum Physics · Physics 2022-10-19 Tobias Graß

We present a compendium of numerical simulation techniques, based on tensor network methods, aiming to address problems of many-body quantum mechanics on a classical computer. The core setting of this anthology are lattice problems in low…

Quantum devices offer a highly useful function - that is generating random numbers in a non-deterministic way since the measurement of a quantum state is not deterministic. This means that quantum devices can be constructed that generate…

Quantum Physics · Physics 2024-02-13 Elijah Pelofske

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

We propose a new method for solving binary optimization problems under inequality constraints using a quantum annealer. To deal with inequality constraints, we often use slack variables, as in previous approaches. When we use slack…

Quantum Physics · Physics 2020-12-14 Kouki Yonaga , Masamichi J. Miyama , Masayuki Ohzeki

Polymers exhibit complex architectures and diverse properties that place them at the center of contemporary research in chemistry and materials science. As conventional computational techniques, even multi-scale ones, struggle to capture…

Quantum Physics · Physics 2025-12-23 Alexandrina Stoyanova , Bogdan Penkovsky

The demand for classical-quantum hybrid algorithms to solve large-scale combinatorial optimization problems using quantum annealing (QA) has increased. One approach involves obtaining an approximate solution using classical algorithms and…

Quantum Physics · Physics 2024-11-12 Taisei Takabayashi , Masayuki Ohzeki

Quantifying quantum entanglement is a pivotal challenge in quantum information science, particularly for high-dimensional systems, due to its computational complexity. This thesis extends the geometric measure of entanglement (GME) to…

Quantum Physics · Physics 2025-06-16 Xuanran Zhu

Lattice QCD in the strong coupling regime can be formulated in dual variables which are integer-valued. It can be efficiently simulated for modest finite temperatures and finite densities via the worm algorithm, circumventing the finite…

High Energy Physics - Lattice · Physics 2023-07-18 Jangho Kim , Thomas Luu , Wolfgang Unger

Machine learning is actively being explored for its potential to design, validate, and even hybridize with near-term quantum devices. A central question is whether neural networks can provide a tractable representation of a given quantum…

Quantum Physics · Physics 2018-06-19 Giacomo Torlai , Roger G. Melko

Quantum annealing is a proposed combinatorial optimization technique meant to exploit quantum mechanical effects such as tunneling and entanglement. Real-world quantum annealing-based solvers require a combination of annealing and classical…

Quantum Physics · Physics 2015-07-30 Kenneth M. Zick , Omar Shehab , Matthew French

With the advent of novel quantum computing technologies, and the knowledge that such technology might be used to fundamentally change computing applications, a prime opportunity has presented itself to investigate the practical application…

Computational Engineering, Finance, and Science · Computer Science 2024-02-13 Kevin Wils , Boyang Chen

Classical computation of electronic properties in large-scale materials remains challenging. Quantum computation has the potential to offer advantages in memory footprint and computational scaling. However, general and practical quantum…

Computational Physics · Physics 2025-10-14 Yiran Bai , Feng Xiong , Xueheng Kuang
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