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This paper proposes a task-driven computational framework for assessing diffusion MRI experimental designs which, rather than relying on parameter-estimation metrics, directly measures quantitative task performance. Traditional…

Medical Physics · Physics 2021-10-12 Sean C. Epstein , Timothy J. P. Bray , Margaret A. Hall-Craggs , Hui Zhang

Heterogeneous treatment effect estimation is an important problem in precision medicine. Specific interests lie in identifying the differential effect of different treatments based on some external covariates. We propose a novel…

Methodology · Statistics 2024-10-21 Peter Chang , Arkaprava Roy

Continuous biomarkers are common for disease screening and diagnosis. To reach a dichotomous clinical decision, a threshold would be imposed to distinguish subjects with disease from non-diseased individuals. Among various performance…

Methodology · Statistics 2021-04-21 Ziyi Li , Yijuan Huang , Dattatraya Patil , Martin G. Sanda

Conditional independence (CI) is central to causal inference, feature selection, and graphical modeling, yet it is untestable in many settings without additional assumptions. Existing CI tests often rely on restrictive structural…

Machine Learning · Computer Science 2025-12-23 Alek Frohlich , Vladimir Kostic , Karim Lounici , Daniel Perazzo , Massimiliano Pontil

This paper reconsiders the problem of testing the equality of two unspecified continuous distributions. The framework, which we propose, allows for readable and insightful data visualisation and helps to understand and quantify how two…

Methodology · Statistics 2025-03-04 Bogdan Ćmiel , Teresa Ledwina

The Area Under the the Receiver Operating Characteristics (ROC) Curve, referred to as AUC, is a well-known performance measure in the supervised learning domain. Due to its compelling features, it has been employed in a number of studies to…

Machine Learning · Computer Science 2023-04-05 Pablo Andretta Jaskowiak , Ivan Gesteira Costa , Ricardo José Gabrielli Barreto Campello

We study the inference problem in the group testing to identify defective items from the perspective of the decision theory. We introduce Bayesian inference and consider the Bayesian optimal setting in which the true generative process of…

Information Theory · Computer Science 2021-10-22 Ayaka Sakata , Yoshiyuki Kabashima

Studying the flow of information between different areas of the brain can be performed by using the so-called Partial Directed Coherence. This measure is usually evaluated by first identifying a multivariate autoregressive model, and then…

Neurons and Cognition · Quantitative Biology 2013-11-26 Pierre-Olivier Amblard

We study an optimal threshold functional arising in binary classification for continuous biomarkers. While the ROC curve summarizes discriminatory performance across all thresholds, practical threshold selection must also account for…

Methodology · Statistics 2026-05-11 Renato de Paula , Helena Mouriño , Tiago Dias Domingues

On the basis of convolutional (Hamming) version of recent Neural Network Assembly Memory Model (NNAMM) for intact two-layer autoassociative Hopfield network optimal receiver operating characteristics (ROCs) have been derived analytically. A…

Artificial Intelligence · Computer Science 2007-05-23 Petro M. Gopych

We introduce methods and theory for fractionally cointegrated curve time series. We develop a variance-ratio test to determine the dimensions associated with the nonstationary and stationary subspaces. For each subspace, we apply a local…

Statistics Theory · Mathematics 2024-09-10 Won-Ki Seo , Han Lin Shang

Conventional approaches to statistical inference preclude structures that facilitate incorporation of supplemental information acquired from similar circumstances. For example, the analysis of data obtained using perfusion computed…

Applications · Statistics 2015-11-18 Thomas A. Murray , Brian P. Hobbs , Bradley P. Carlin

No matter the nature of the response and/or explanatory variables in a regression model, some basic issues such as the existence of an effect of the predictor on the response, or the assessment of a common shape across groups of…

Applications · Statistics 2020-09-01 María Alonso-Pena , Jose Ameijeiras-Alonso , Rosa M. Crujeiras

We propose a parallel algorithm for local, on the fly, model checking of a fragment of CTL that is well-suited for modern, multi-core architectures. This model-checking algorithm takes bene t from a parallel state space construction…

Logic in Computer Science · Computer Science 2013-02-01 Rodrigo Tacla Saad , Silvano Dal Zilio , Bernard Berthomieu

The Area Under the ROC Curve (AUC) is a crucial metric for machine learning, which evaluates the average performance over all possible True Positive Rates (TPRs) and False Positive Rates (FPRs). Based on the knowledge that a skillful…

Machine Learning · Computer Science 2022-06-24 Zhiyong Yang , Qianqian Xu , Shilong Bao , Yuan He , Xiaochun Cao , Qingming Huang

In this paper, we consider the interference rejection combining (IRC) receiver, which improves the cell-edge user throughput via suppressing inter-cell interference and requires estimating the covariance matrix including the inter-cell…

Information Theory · Computer Science 2023-06-21 Jing Qian , Juening Jin , Hao Wang

Two different approaches to analysis of data from diagnostic biomarker studies are commonly employed. Logistic regression is used to fit models for probability of disease given marker values, while ROC curves and risk distributions are used…

Applications · Statistics 2013-12-02 Ying Huang , Margaret S. Pepe , Ziding Feng

We propose conformal hyperrectangular prediction regions for multi-target regression. We propose split conformal prediction algorithms for both point and quantile regression to form hyperrectangular prediction regions, which allow for easy…

Methodology · Statistics 2024-06-10 Max Sampson , Kung-Sik Chan

Randomization tests are a popular method for testing causal effects in clinical trials with finite-sample validity. In the presence of heterogeneous treatment effects, it is often of interest to select a subgroup that benefits from the…

Methodology · Statistics 2025-04-29 Zijun Gao

Most binary classifiers work by processing the input to produce a scalar response and comparing it to a threshold value. The various measures of classifier performance assume, explicitly or implicitly, probability distributions $P_s$ and…

Machine Learning · Computer Science 2019-09-24 Luma Omar , Ioannis Ivrissimtzis
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