Related papers: Feedback-controlled microbubble generator producin…
We use a rigid axisymetric microfluidic flow focusing device to produce monodisperse bubbles, dispersed in a surfactant solution. The gas volume fraction of the dispersion collected out of this device can be as large as 90%, demonstrating…
Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development…
We present a novel microfluidic method to produce quasi-monodisperse bubbles with diameters from tens to very few microns. A gaseous rivulet flows over the shallow groove printed on a T-junction exit channel. The triple contact line…
The acoustic response of microbubbles (MBs) depends on their resonance frequency, which is dependent on MB size and shell properties. Monodisperse MBs with tunable shell properties are thus desirable for optimizing and controlling MB…
In the paper, we succeeded to freeze-dry monodisperse microbubbles without degrading their size and acoustic properties. We used microfluidic technology to generate highly monodisperse (coefficient of variation, CV<5%) microbubbles and…
Monodisperse microbubble ultrasound contrast agents have been proposed to further increase the signal-to-noise-ratio of contrast enhanced ultrasound imaging. Here, the sensitivity of a polydisperse preclinical agent was compared…
The production of monodisperse particles or droplets is a longstanding issue across various fields, from aerosol science to inkjet printing. In bioengineering, submillimeter cell laden hydrogel capsules have proven valuable for developing…
Short (40-200 microseconds) single focused CO2 laser pulses of energy of about 100 microJ were used to fabricate high quality concave micromirror templates on silica and fluoride glass. The ablated features have diameters of 20-100 microns…
We introduce a novel technique to produce monodisperse droplets through the snap-off mechanism. The methodology is simple, versatile, and requires no specialized or expensive components. The droplets produced have polydispersity <1% and can…
On-demand controlled drug delivery is essential for the treatment of a wide range of chronic diseases. As the drug is released at the time when required, its efficacy is boosted and the side effects are minimized. However, so far, drug…
Contrast-enhanced ultrasound (CEUS) presents distinct advantages in diagnostic echography. Utilizing microbubbles (MBs) as conventional contrast agents enhances vascular visualization and organ perfusion, facilitating real-time,…
In this work, we introduce the novel technique of in-chip drop on demand, which consists in dispensing picoliter to nanoliter drops on demand directly in the liquid-filled channels of a polymer microfluidic chip, at frequencies up to 2.5…
We present an experimental investigation of the agglomeration of microbubbles into a 2D microfoam and its flow in a rectangular microchannel. Using a flow-focusing method, we produce the foam in situ on a microfluidic chip for a large range…
We present a scalable method for producing monodisperse micro-scale emulsions in a rectangular container holding two stably stratified layers of immiscible liquids by applying horizontal vibration. This setup enables the excitation of a…
Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their…
Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress in this…
This paper demonstrates that disposable polyester-toner microfluidic devices are suitable to produce either water-in-oil (W/O) or oil-in-water (O/W) droplets without using any surface treatment of the microchannels walls. Highly…
Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that…
Control of dispersion in fibre optical waveguides is of critical importance to optical fibre communications systems and more recently for continuum generation from the ultraviolet to the mid-infrared. The wavelength at which the group…
Inexpensive, portable lab-on-a-chip devices would revolutionize fields like environmental monitoring and global health, but current microfluidic chips are tethered to extensive off-chip hardware. Insects, however, are self-contained and…