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This paper presents a genetic-based hybrid algorithm that combines the exploration power of Genetic Algorithm (GA) with the exploitation capacity of a phenotypical probabilistic local search algorithm. Though not limited to a certain class…

Optimization and Control · Mathematics 2016-11-26 Reza Najian Asl , Mohamad Aslani , Masoud Shariat Panahi

Cancer cells evolve through random somatic mutations. "Beneficial" mutations which disrupt key pathways (e.g. cell cycle regulation) are subject to natural selection. Multiple mutations may lead to the same "beneficial" effect, in which…

Methodology · Statistics 2016-09-20 Paul Ginzberg , Federico Giorgi , Andrea Califano

We propose a genetic algorithm (GA) for hyperparameter optimization of artificial neural networks which includes chromosomal crossover as well as a decoupling of parameters (i.e., weights and biases) from hyperparameters (e.g., learning…

Neural and Evolutionary Computing · Computer Science 2019-01-15 Aaron Vose , Jacob Balma , Alex Heye , Alessandro Rigazzi , Charles Siegel , Diana Moise , Benjamin Robbins , Rangan Sukumar

For genetic algorithms using a bit-string representation of length~$n$, the general recommendation is to take $1/n$ as mutation rate. In this work, we discuss whether this is really justified for multimodal functions. Taking jump functions…

Neural and Evolutionary Computing · Computer Science 2017-03-23 Benjamin Doerr , Huu Phuoc Le , Régis Makhmara , Ta Duy Nguyen

We introduce a novel strategy employing an adaptive genetic algorithm (GA) for iterative optimization of control sequences to generate quantum nonclassical states. Its efficacy is demonstrated by preparing spin-squeezed states in an open…

Quantum Physics · Physics 2025-11-25 Yiming Zhao , Libo Chen , Yong Wang , Hongyang Ma , Xiaolong Zhao

The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a…

Neural and Evolutionary Computing · Computer Science 2012-05-30 Arnab Ghosh , Avishek Ghosh , Arkabandhu Chowdhury , Amit Konar

The $(1+(\lambda,\lambda))$ genetic algorithm is a bright example of an evolutionary algorithm which was developed based on the insights from theoretical findings. This algorithm uses crossover, and it was shown to asymptotically outperform…

Neural and Evolutionary Computing · Computer Science 2020-05-12 Anton Bassin , Maxim Buzdalov

There is considerable interest in the use of genetic algorithms to solve problems arising in the areas of scheduling and timetabling. However, the classical genetic algorithm paradigm is not well equipped to handle the conflict between…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Kathryn Dowsland

The rapid advances in the field of optimization methods in many pure and applied science pose the difficulty of keeping track of the developments as well as selecting an appropriate technique that best suits the problem in-hand. From a…

Neural and Evolutionary Computing · Computer Science 2011-12-30 Loris Serafino

We propose a framework of genetic algorithms which use multi-level hierarchies to solve an optimization problem by searching over the space of simpler objective functions. We solve a variant of Travelling Salesman Problem called…

Neural and Evolutionary Computing · Computer Science 2019-08-06 Harshavardhan Kamarthi , Kousik Krishnan

Adaptive nuclear-norm penalization is proposed for low-rank matrix approximation, by which we develop a new reduced-rank estimation method for the general high-dimensional multivariate regression problems. The adaptive nuclear norm of a…

Methodology · Statistics 2012-09-25 Kun Chen , Hongbo Dong , Kung-Sik Chan

The Genetic Algorithm is a heuristic that can be used to produce model independent solutions to an optimization problem, thus making it ideal for use in cosmology and more specifically in the analysis of type Ia supernovae data. In this…

Cosmology and Nongalactic Astrophysics · Physics 2011-03-18 Savvas Nesseris

In recent years, machine learning has seen an increasing presencein a large variety of fields, especially in health care and bioinformatics.More specifically, the field where machine learning algorithms have found most applications is…

Neural and Evolutionary Computing · Computer Science 2020-08-21 Mekaal Swerhun , Jasmine Foley , Brandon Massop , Vijay Mago

In this work, we present an extension of the genetic algorithm (GA) which exploits the supervised learning technique called active subspaces (AS) to evolve the individuals on a lower dimensional space. In many cases, GA requires in fact…

Numerical Analysis · Mathematics 2021-07-13 Nicola Demo , Marco Tezzele , Gianluigi Rozza

When a Genetic Algorithm (GA), or a stochastic algorithm in general, is employed in a statistical problem, the obtained result is affected by both variability due to sampling, that refers to the fact that only a sample is observed, and…

Computation · Statistics 2019-03-07 Manuel Rizzo , Francesco Battaglia

While many optimization problems work with a fixed number of decision variables and thus a fixed-length representation of possible solutions, genetic programming (GP) works on variable-length representations. A naturally occurring problem…

Neural and Evolutionary Computing · Computer Science 2018-06-07 Benjamin Doerr , Timo Kötzing , J. A. Gregor Lagodzinski , Johannes Lengler

This thesis investigates the use of problem-specific knowledge to enhance a genetic algorithm approach to multiple-choice optimisation problems.It shows that such information can significantly enhance performance, but that the choice of…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin

Optimization of data placement in complex scientific workflows has become very crucial since the large amounts of data generated by these workflows significantly increases the turnaround time of the end-to-end application. It is almost…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-29 Dengpan Yin , Tevfik Kosar

Genetic Algorithms (GAs) are explored as a tool for probing new physics with high dimensionality. We study the 19-dimensional pMSSM, including experimental constraints from all sources and assessing the consistency of potential signals of…

High Energy Physics - Phenomenology · Physics 2018-05-14 Steven Abel , David G. Cerdeno , Sandra Robles

The interest in accelerating black-box optimizers has resulted in several surrogate model-assisted version of the Covariance Matrix Adaptation Evolution Strategy, a state-of-the-art continuous black-box optimizer. The version called…

Neural and Evolutionary Computing · Computer Science 2017-10-02 Jakub Repicky , Lukas Bajer , Zbynek Pitra , Martin Holena