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How to induce differentiated cells into pluripotent cells has elicited researchers' interests for a long time since pluripotent stem cells are able to offer remarkable potential in numerous subfields of biological research. However, the…

Molecular Networks · Quantitative Biology 2014-12-09 Jiawei Yan , Pu Zheng , Xingjie Pan

Deep ensembles excel in large-scale image classification tasks both in terms of prediction accuracy and calibration. Despite being simple to train, the computation and memory cost of deep ensembles limits their practicability. While some…

Machine Learning · Computer Science 2021-10-28 Giung Nam , Jongmin Yoon , Yoonho Lee , Juho Lee

In this paper, we investigate a model describing induction hardening of steel. The related system consists of an energy balance, an ODE for the different phases of steel, and Maxwell's equations in a potential formulation. The existence of…

Analysis of PDEs · Mathematics 2023-12-22 Dietmar Hömberg , Robert Lasarzik

We introduce a model of the growth of a single microorganism in a self-cycling fermentor in which an arbitrary number of resources are limiting, and impulses are triggered when the concentration of one specific substrate reaches a…

Dynamical Systems · Mathematics 2020-04-28 Tyler Meadows , Gail S. K. Wolkowicz

Score-based diffusion models have emerged as powerful techniques for generating samples from high-dimensional data distributions. These models involve a two-phase process: first, injecting noise to transform the data distribution into a…

Machine Learning · Computer Science 2024-10-21 Runjia Li , Qiwei Di , Quanquan Gu

Widely used closed product-form networks have emerged recently as a primary model of stochastic growth of sub-cellular structures, e.g., cellular filaments. In the baseline model, homogeneous monomers attach and detach stochastically to…

Probability · Mathematics 2020-07-30 Predrag Jelenkovic , Jane Kondev , Lishibanya Mohapatra , Petar Momcilovic

We propose a class of evolutionary models that involves an arbitrary exchangeable process as the breeding process and different selection schemes. In those models, a new genome is born according to the breeding process, and then a genome is…

Neural and Evolutionary Computing · Computer Science 2020-08-25 Jüri Lember , Chris Watkins

We consider a size-structured model for cell division and address the question of determining the division (birth) rate from the measured stable size distribution of the population. We formulate such question as an inverse problem for an…

Analysis of PDEs · Mathematics 2009-11-11 Benoit Perthame , Jorge P. Zubelli

We consider systematic numerical approximation of a viscoelastic phase separation model that describes the demixing of a polymer solvent mixture. An unconditionally stable discretisation method is proposed based on a finite element…

Numerical Analysis · Mathematics 2024-07-08 Aaron Brunk , Herbert Egger , Oliver Habrich , Maria Lukacova-Medvidova

A decomposition principle for nonlinear dynamic compartmental systems is introduced in the present paper. This theory is based on the mutually exclusive and exhaustive, analytical and dynamic, novel system and subsystem partitioning…

Systems and Control · Computer Science 2020-11-24 Huseyin Coskun

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

The abrupt outbreak and transmission of biological diseases has always been a long-time concern of humankind. For long, mathematical modeling has served as a simple and yet efficient tool to investigate, predict, and control spread of…

Populations and Evolution · Quantitative Biology 2020-04-10 Aresh Dadlani , Richard O. Afolabi , Hyoyoung Jung , Khosrow Sohraby , Kiseon Kim

Modelling the dynamics of dense granular media is a long standing challenge and essential to many natural phenomena and technological applications. Here, we trace back puzzling experimental observation of detailed-balanced steady states to…

Soft Condensed Matter · Physics 2024-10-29 Clara C. Wanjura , Amelie Mayländer , Othmar Marti , Raphael Blumenfeld

In recent years, conditional copulas, that allow dependence between variables to vary according to the values of one or more covariates, have attracted increasing attention. In high dimension, vine copulas offer greater flexibility compared…

Methodology · Statistics 2021-09-24 Rosario Barone , Luciana Dalla Valle

Many data-driven decision problems are formulated using a nominal distribution estimated from historical data, while performance is ultimately determined by a deployment distribution that may be shifted, context-dependent, partially…

Machine Learning · Computer Science 2026-04-07 Xiuyuan Cheng , Yunqin Zhu , Yao Xie

Inferring the directionality of interactions between cellular processes is a major challenge in systems biology. Time-lagged correlations allow to discriminate between alternative models, but they still rely on assumed underlying…

Quantitative Methods · Quantitative Biology 2017-11-15 Sourabh Lahiri , Philippe Nghe , Sander J. Tans , Martin Luc Rosinberg , David Lacoste

Estimating individualized treatment effects from observational data is a central challenge in causal inference, largely due to covariate imbalance and confounding bias from non-randomized treatment assignment. While inverse probability…

Machine Learning · Computer Science 2025-05-19 Xinran Song , Tianyu Chen , Mingyuan Zhou

We present a model for the silicosis disease mechanism following the original proposal by Tran, Jones, and Donaldson (1995) [9], as modified recently by da Costa, Drmota, and Grinfeld (2020) [4]. The model consists in an infinite ordinary…

Classical Analysis and ODEs · Mathematics 2021-01-29 Fernando P. da Costa , João T. Pinto , Rafael Sasportes

The current survey paper concerns stochastic mathematical models for the spread of infectious diseases. It starts with the simplest setting of a homogeneous population in which a transmittable disease spreads during a short outbreak.…

Applications · Statistics 2018-01-30 Tom Britton

We present a simple model for describing the dynamics of the interaction between a homogeneous population or society, and the natural resources and reserves that the society needs for its survival. The model is formulated in terms of…

Physics and Society · Physics 2020-04-22 Basil Grammaticos , Ralph Willox , Junkichi Satsuma