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Biofilms are bacterial aggregates that grow on moist surfaces. Thin homogeneous biofilms naturally formed on the walls of conducts may serve as biosensors, providing information on the status of microsystems (MEMS) without disrupting them.…

Soft Condensed Matter · Physics 2024-01-17 Ana Carpio , Baldvin Einarsson , David R. Espeso

In this paper, we derive upscaled equations for modelling biofilm growth in porous media. The resulting macro-scale mathematical models consider permeable multi-species biofilm including water flow, transport, detachment and reactions. The…

A stochastic model is used to assess the effect of external parameters on the development of submerged biofilms on smooth and rough surfaces. The model includes basic cellular mechanisms, such as division and spreading, together with an…

Soft Condensed Matter · Physics 2024-01-17 David Rodriguez , Baldvin Einarsson , Ana Carpio

Biofilm growth changes many physical properties of porous media such as porosity, permeability and mass transport parameters. The growth depends on various environmental conditions, and in particular, on flow rates. Modeling the evolution…

We derive a physiologically structured multiscale model for biofilm development. The model has components on two spatial scales, which induce different time scales into the problem. The macroscopic behavior of the system is modeled using…

Cell Behavior · Quantitative Biology 2023-02-14 Bruce P. Ayati , Isaac Klapper

From multicellular tissues to bacterial colonies, three dimensional cellular structures arise through the interaction of cellular activities and mechanical forces. Simple bacterial communities provide model systems for analyzing such…

Soft Condensed Matter · Physics 2024-01-11 Ana Carpio , Elena Cebrian , David R. Espeso , Perfecto Vidal

Bacillus subtilis biofilms were grown in laminar channel flow at wall shear stress spanning one order of magnitude ($\tau_w = 0.068$ Pa to $\tau_w = 0.67$ Pa). We monitor, non-invasively, the evolution of the three-dimensional distribution…

Bacterial biofilms play a significant role in various fields that impact our daily lives, from detrimental public health hazards to beneficial applications in bioremediation, biodegradation, and wastewater treatment. However,…

The work presents the analysis of the free boundary value problem related to the invasion model of new species in biofilm reactors. In the framework of continuum approach to mathematical modelling of biofilm growth, the problem consists of…

Biological Physics · Physics 2021-04-09 Berardino D'Acunto , Luigi Frunzo , Vincenzo Luongo , Maria Rosaria Mattei

We propose a computational framework to study the growth and spread of bacterial biofilms on interfaces, as well as the action of antibiotics on them. Bacterial membranes are represented by boundaries immersed in a fluid matrix and subject…

Cell Behavior · Quantitative Biology 2022-01-11 Ana Carpio , Rafael Gonzalez-Albaladejo

In the manufacturing process of high-performance particulate materials, viscous sintering plays a crucial role, particularly in fields such as polymer processing and additive manufacturing. The interactions between microscopic particles,…

Computational Engineering, Finance, and Science · Computer Science 2024-12-06 Xiaoxu Dai , Bo Qian , Arkadz Kirshtein , Qingcheng Yang

We present the stability analysis of two free boundary problems arising in biofilm modelling. The first, introduced in the 1980s by Wanner and Gujer, is related to the competition between autotrophic and heterotrophic bacteria in a biofilm…

Analysis of PDEs · Mathematics 2025-03-26 Dieudonné Zirhumanana Balike , Maria Rosaria Mattei , Luigi Frunzo

Lipid bilayer membranes are the fundamental biological barriers that permit life. The bilayer dynamics largely participates in orchestrating cellular workings and is characterized by substantial stability together with extreme plasticity…

Soft Condensed Matter · Physics 2022-12-05 Matteo Bottacchiari , Mirko Gallo , Marco Bussoletti , Carlo Massimo Casciola

The dynamics of biofilm lifecycle are deeply influenced by the surrounding environment and the interactions between sessile and planktonic phenotypes. Bacterial biofilms typically develop in three distinct stages: attachment of cells to a…

Analysis of PDEs · Mathematics 2021-07-07 B. D'Acunto , L. Frunzo , V. Luongo , M. R. Mattei , A. Tenore

In this article, we study in details the fluid dynamics system proposed in Clarelli et al (2013) to model the formation of cyanobacteria biofilms. After analyzing the linear stability of the unique non trivial equilibrium of the system, we…

Fluid Dynamics · Physics 2014-08-12 Fabrizio Clarelli , Cristiana Di Russo , Roberto Natalini , Magali Ribot

A mathematical model for emerging contaminants sorption in multispecies biofilms, based on a continuum approach and mass conservation principles is presented. Diffusion of contaminants within the biofilm is described using a…

Cell Behavior · Quantitative Biology 2017-06-15 Luigi Frunzo

Bacterial biofilms are among the oldest and most prevalent multicellular life forms on Earth and are increasingly relevant in research areas related to industrial fouling, medicine and biotechnology. The main hurdles to obtaining definitive…

Quantitative Methods · Quantitative Biology 2021-10-20 Mohammad Pousti , MirPouyan Zarabadi , Mehran Abbaszadeh Amirdehi , François Paquet-Mercier , Jesse Greener

In this paper we derive a pore-scale model for permeable biofilm formation in a two-dimensional pore. The pore is divided in two phases: water and biofilm. The biofilm is assumed to consist of four components: water, extracellular polymeric…

A hydrodynamic model is proposed to describe one of the most critical problems in intensive medical care units: the formation of biofilms inside central venous catheters. The incorporation of approximate solutions for the flow-limited…

The locomotion of microorganisms and spermatozoa in complex viscoelastic fluids is of critical importance in many biological processes such as fertilization, infection, and biofilm formation. Depending on their propulsion mechanisms,…

Soft Condensed Matter · Physics 2021-09-14 Gaojin Li , Eric Lauga , Arezoo M. Ardekani
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