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In high-dimensional statistical inference in which the number of parameters to be estimated is larger than that of the holding data, regularized linear estimation techniques are widely used. These techniques have, however, some drawbacks.…

Methodology · Statistics 2025-08-06 Takashi Takahashi , Yoshiyuki Kabashima

Statistical inferences for high-dimensional regression models have been extensively studied for their wide applications ranging from genomics, neuroscience, to economics. However, in practice, there are often potential unmeasured…

Methodology · Statistics 2023-09-12 Jing Ouyang , Kean Ming Tan , Gongjun Xu

We consider the problem of estimating a low-dimensional parameter in high-dimensional linear regression. Constructing an approximately unbiased estimate of the parameter of interest is a crucial step towards performing statistical…

Statistics Theory · Mathematics 2021-07-30 Michael Celentano , Andrea Montanari

In this paper, we propose a new method for estimation and constructing confidence intervals for low-dimensional components in a high-dimensional model. The proposed estimator, called Constrained Lasso (CLasso) estimator, is obtained by…

Methodology · Statistics 2017-04-19 Yun Yang

There are many settings where researchers are interested in estimating average treatment effects and are willing to rely on the unconfoundedness assumption, which requires that the treatment assignment be as good as random conditional on…

Methodology · Statistics 2018-02-02 Susan Athey , Guido W. Imbens , Stefan Wager

We propose a robust inferential procedure for assessing uncertainties of parameter estimation in high-dimensional linear models, where the dimension $p$ can grow exponentially fast with the sample size $n$. Our method combines the…

Machine Learning · Statistics 2015-03-19 Tianqi Zhao , Mladen Kolar , Han Liu

In this paper, we introduce a unified framework, inspired by classical regularization theory, for designing and analyzing a broad class of linear regression approaches. Our framework encompasses traditional methods like least squares…

Statistics Theory · Mathematics 2025-03-04 Ying-Ao Wang , Yunyi Zhang , Ye Zhang

Modeling and drawing inference on the joint associations between single nucleotide polymorphisms and a disease has sparked interest in genome-wide associations studies. In the motivating Boston Lung Cancer Survival Cohort (BLCSC) data, the…

Methodology · Statistics 2021-11-18 Lu Xia , Bin Nan , Yi Li

This study introduces a debiasing method for regression estimators, including high-dimensional and nonparametric regression estimators. For example, nonparametric regression methods allow for the estimation of regression functions in a…

Machine Learning · Statistics 2024-11-27 Masahiro Kato

Motivated by the simultaneous association analysis with the presence of latent confounders, this paper studies the large-scale hypothesis testing problem for the high-dimensional confounded linear models with both non-asymptotic and…

Methodology · Statistics 2023-08-24 Yinrui Sun , Li Ma , Yin Xia

Debiasing group graphical lasso estimates enables statistical inference when multiple Gaussian graphical models share a common sparsity pattern. We analyze the estimation properties of group graphical lasso, establishing convergence rates…

Statistics Theory · Mathematics 2025-10-07 Sayan Ranjan Bhowal , Debashis Paul , Gopal K Basak , Samarjit Das

High-dimensional regression models with regularized sparse estimation are widely applied. For statistical inferences, debiased methods are available about single coefficients or predictions with sparse new covariate vectors (also called…

Statistics Theory · Mathematics 2025-07-16 Libin Liang , Zhiqiang Tan

Completely randomized experiment is the gold standard for causal inference. When the covariate information for each experimental candidate is available, one typical way is to include them in covariate adjustments for more accurate treatment…

Methodology · Statistics 2025-06-10 Xin Lu , Fan Yang , Yuhao Wang

Performing statistical inference in high-dimension is an outstanding challenge. A major source of difficulty is the absence of precise information on the distribution of high-dimensional estimators. Here, we consider linear regression in…

Statistics Theory · Mathematics 2016-06-15 Adel Javanmard , Andrea Montanari

For statistical inference on regression models with a diverging number of covariates, the existing literature typically makes sparsity assumptions on the inverse of the Fisher information matrix. Such assumptions, however, are often…

Methodology · Statistics 2021-06-08 Lu Xia , Bin Nan , Yi Li

We consider statistical inference for a single coordinate of regression coefficients in high-dimensional linear models. Recently, the debiased estimators are popularly used for constructing confidence intervals and hypothesis testing in…

Statistics Theory · Mathematics 2020-10-20 Sai Li

Classically, confidence intervals are required to have consistent coverage across all values of the parameter. However, this will inevitably break down if the underlying estimation procedure is biased. For this reason, many efforts have…

Methodology · Statistics 2025-08-06 Logan Harris , Patrick Breheny

Statistical inference of the high-dimensional regression coefficients is challenging because the uncertainty introduced by the model selection procedure is hard to account for. A critical question remains unsettled; that is, is it possible…

Methodology · Statistics 2025-01-06 Xiaorui Zhu , Yichen Qin , Peng Wang

Many high-dimensional data sets suffer from hidden confounding which affects both the predictors and the response of interest. In such situations, standard regression methods or algorithms lead to biased estimates. This paper substantially…

Methodology · Statistics 2024-12-17 Cyrill Scheidegger , Zijian Guo , Peter Bühlmann

This paper studies schemes to de-bias the Lasso in a linear model $y=X\beta+\epsilon$ where the goal is to construct confidence intervals for $a_0^T\beta$ in a direction $a_0$, where $X$ has iid $N(0,\Sigma)$ rows. We show that previously…

Statistics Theory · Mathematics 2021-07-09 Pierre C. Bellec , Cun-Hui Zhang
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