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Quantum annealing has shown promise for finding solutions to difficult optimization problems, including protein folding. Recently, we used the D-Wave Advantage quantum annealer to explore the folding problem in a coarse-grained lattice…

Quantum Physics · Physics 2024-02-15 Anders Irbäck , Lucas Knuthson , Sandipan Mohanty , Carsten Peterson

Quantum annealing is a contender to solve combinatorial optimization problems based on quantum dynamics. While significant efforts have been undertaken to investigate the quality of the solutions and the required runtimes, much less…

Statistical Mechanics · Physics 2023-06-05 Artem Rakcheev , Andreas M. Läuchli

Quantum entanglement is an essential feature of many-body systems that impacts both quantum information processing and fundamental physics. The growth of entanglement is a major challenge for classical simulation methods. In this work, we…

Quantum Physics · Physics 2025-07-15 Qi Zhao , You Zhou , Andrew M. Childs

Quantum annealing is a novel type of analog computation that aims to use quantum mechanical fluctuations to search for optimal solutions of Ising problems. Quantum annealing in the Transverse Ising model, implemented on D-Wave QPUs, are…

Quantum Physics · Physics 2025-03-14 Elijah Pelofske

While quantum computing proposes promising solutions to computational problems not accessible with classical approaches, due to current hardware constraints, most quantum algorithms are not yet capable of computing systems of practical…

Quantum annealing (QA) is one of the ways to search the ground state of the problem Hamiltonian. Here, we propose the QA scheme to search arbitrary excited states of the problem Hamiltonian. In our scheme, an $n$-th excited state of the…

Quantum Physics · Physics 2021-04-21 Yuya Seki , Yuichiro Matsuzaki , Shiro Kawabata

Contrary to the assumption that most quantum error-correcting codes (QECC) make, it is expected that phase errors are much more likely than bit errors in physical devices. By employing the entanglement-assisted stabilizer formalism, we…

Quantum Physics · Physics 2011-04-27 Yuichiro Fujiwara , Min-Hsiu Hsieh

Quantum Annealing has proven to be a powerful tool to tackle several optimization problems. However, its performance is severely impacted by the limited connectivity of the underlying quantum hardware, compromising the quantum speedup. In…

Quantum Physics · Physics 2024-03-21 Raúl Santos , Lorenzo Buffoni , Yasser Omar

In this review, after providing the basic physical concept behind quantum annealing (or adiabatic quantum computation), we present an overview of some recent theoretical as well as experimental developments pointing to the issues which are…

Statistical Mechanics · Physics 2023-01-18 Atanu Rajak , Sei Suzuki , Amit Dutta , Bikas K. Chakrabarti

One of the current major challenges surrounding the use of quantum annealers for solving practical optimization problems is their inability to encode even moderately sized problems---the main reason for this being the rigid layout of their…

Quantum Physics · Physics 2016-10-03 Itay Hen , Marcelo S. Sarandy

Characterizing thermally activated transitions in high-dimensional rugged energy surfaces is a very challenging task for classical computers. Here, we develop a quantum annealing scheme to solve this problem. First, the task of finding the…

Quantum Physics · Physics 2021-01-18 Philipp Hauke , Giovanni Mattiotti , Pietro Faccioli

Adiabatic quantum computation provides an alternative approach to quantum computation using a time-dependent Hamiltonian. The time evolution of entanglement during the adiabatic quantum search algorithm is studied, and its relevance as a…

Quantum Physics · Physics 2009-11-11 Daria Ahrensmeier

The logistic network design is an abstract optimization problem that, under the assumption of minimal cost, seeks the optimal configuration of the supply chain's infrastructures and facilities based on customer demand. Key economic…

Quantum Physics · Physics 2021-02-04 Yongcheng Ding , Xi Chen , Lucas Lamata , Enrique Solano , Mikel Sanz

Markov chain Monte Carlo algorithms have important applications in counting problems and in machine learning problems, settings that involve estimating quantities that are difficult to compute exactly. How much can quantum computers speed…

Quantum Physics · Physics 2020-02-10 Aram W. Harrow , Annie Y. Wei

Entanglement asymmetry has emerged as a powerful tool for characterizing symmetry breaking in quantum many-body systems. In this Letter, we explore how symmetry is dynamically broken through the lens of entanglement asymmetry in two…

Quantum Physics · Physics 2025-09-26 Hui Yu , Zi-Xiang Li , Shi-Xin Zhang

Calibrating the role of entanglement in quantum algorithms is a crucial task in the development of quantum computing. Most existing studies have primarily focused on how the static properties of entanglement-such as its magnitude and…

Quantum Physics · Physics 2026-04-28 Chunxiao Du , Yang Zhou , Zhichen Huang , Rui Li , Zheng Qin , Shikun Zhang , Zhisong Xiao

Transcription factors regulate gene expression, but how these proteins recognize and specifically bind to their DNA targets is still debated. Machine learning models are effective means to reveal interaction mechanisms. Here we studied the…

Quantum Physics · Physics 2018-03-02 Richard Y. Li , Rosa Di Felice , Remo Rohs , Daniel A. Lidar

This paper explores the phenomenon of avoided level crossings in quantum annealing, a promising framework for quantum computing that may provide a quantum advantage for certain tasks. Quantum annealing involves letting a quantum system…

Quantum Physics · Physics 2024-04-12 Arthur Braida , Simon Martiel , Ioan Todinca

In this work we investigate the capabilities of a hybrid quantum-classical procedure to explore the solution space using the D-Wave $2000Q^{TM}$ Quantum Annealer device. Here we study the ability of the Quantum hardware to solve the Number…

Quantum Physics · Physics 2020-03-10 Luca Asproni , Davide Caputo , Blanca Silva , Giovanni Fazzi , Marco Magagnini

In this work, we review quantum approaches to combinatorial optimization, with the aim of bridging theoretical developments and industrial relevance. We first survey the main families of quantum algorithms, including Quantum Annealing, the…

Quantum Physics · Physics 2026-03-20 Hala Hawashin , Deep Nath , Marco Alberto Javarone