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Reactive oxygen species (ROS), which are expressed at high levels in many diseases, can be scavenged by cerium oxide nanoparticles (CeO2NPs). CeO2NPs can cause significant cytotoxicity when administered directly to cells, but this…

Cell Behavior · Quantitative Biology 2024-04-29 Ummay Mowshome Jahan , Brianna Blevins , Sergiy Minko , Vladimir Reukov

Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, harmful…

Neutrophils play a central role in immunothrombosis through the formation of neutrophil extracellular traps (NETs), a process known as NETosis. Upon stimulation, neutrophils release decondensed chromatin structures enriched with proteolytic…

Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community due to their unique physical and chemical properties, such as redox activity and oxygen buffering capacity, which made them available for many…

Materials Science · Physics 2021-09-21 Megan S. Lord , Jean Francois Berret , Sanjay Singh , Ajayan Vinu , Ajay S. Karakoti

Due to the increasing use of nanometric cerium oxide in applications, concerns about the toxicity of these particles have been raised and have resulted in a large number of investigations. We report here on the interactions between 7 nm…

Biological Physics · Physics 2013-08-06 N. Ould-Moussa , M. Safi , M. A. Guedeau-Boudeville , D. Montero , H. Conjeaud , J. F. Berret

Functional polymers, such as poly(ethylene glycol) (PEG) terminated with a single phosphonic acid, hereafter PEGik-Ph are often applied to coat metal oxide surfaces during post synthesis steps, but are not sufficient to stabilize sub-10 nm…

This research work showcases a non-toxic approach to synthesize carbon nanoparticles (CNPs) from various medicinal plants namely Syzygium cumini, Holy basil, Azadirachta indica A, Psidium guajava, Mangifera indica, and Bergera koenigii…

Chemical Physics · Physics 2024-01-22 Parul Singh , Aniruddha Dan , Padma Priya Kannan , Mukesh Dhanka , Dhiraj Bhatia , Jhuma Saha

Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To…

Cerium oxide nanoparticles (CNPs) have recently gained increasing interest as redox enzyme-mimetics to scavenge the intracellular excess of reactive oxygen species, including hydrogen peroxide (H2O2). Despite the extensive exploration of…

Soft Condensed Matter · Physics 2023-09-26 Giusy Finocchiaro , Xiaohui Ju , Braham Mezghrani , Jean-François Berret

In a recent publication, we have highlighted the potential of phosphonic acid terminated PEG oligomers to functionalize strong UV absorption cerium oxide nanoparticles[1], which yield suspensions that are stable in aqueous or organic…

Materials Science · Physics 2013-05-07 L. Qi , J. Fresnais , P. Muller , O. Theodoly , J. -F. Berret , J. -P. Chapel

A very small number of biomaterials investigated for bone regeneration was reported as able to prevent the oxidative stress. In this study beads based on alginate hydrogel and mesoporous glasses (MG) containing different amounts of cerium…

Tissues and Organs · Quantitative Biology 2021-05-24 E. Varini , S. Sanchez-Salcedo , G. Malavasi , G. Lusvardi , M. Vallet-Regi , A. J. Salinas

Recent nanotoxicity studies revealed that the physico-chemical characteristics of engineered nanomaterials play an important role in the interactions with living cells. Here, we report on the toxicity and uptake of the cerium and iron oxide…

Materials Science · Physics 2010-11-09 M. Safi , H. Sarrouj , O. Sandre , N. Mignet , J. -F. Berret

Stroke is a leading cause of disability and death worldwide, with ischemic strokes accounting for nearly 80% of cases. Fewer than 5% of patients receive the sole validated pharmacotherapy, intravenous thrombolysis, highlighting the urgent…

Neurons and Cognition · Quantitative Biology 2025-11-25 Sophie Béraud-Dufour , Ilona Legroux , Thierry Coppola , Patricia Lebrun , Nicolas Blondeau

Applications of nanoparticles in biology require that the nanoparticles remain stable in solutions containing high concentrations of proteins and salts, as well as in cell culture media. In this work, we developed simple protocols for the…

Soft Condensed Matter · Physics 2009-07-07 B. Chanteau , J. Fresnais , J. -F. Berret

This review explores the synthesis, characterization, and therapeutic applications of zinc oxide nanoparticles (ZnO NPs) in the treatment of diabetes mellitus. The study delves into both chemical and green synthesis methods, comparing their…

Medical Physics · Physics 2024-09-10 Iqra Yousaf

Cerium oxide nanoparticles are known to catalyze the decomposition of reactive oxygen species such as superoxide radical and hydrogen peroxide. Herein, we examine the superoxide dismutase (SOD) and catalase (CAT) mimetic catalytic…

Materials Science · Physics 2021-09-21 V. Baldim , F. Bedioui , N. Mignet , I. Margaill , J. -F. Berret

Trigeminal neuralgia (TN) is the most common neuropathic disorder; however, its pathogenesis remains unclear. A prevailing theory suggests that nitric oxide (NO) may induce nerve compression and irritation via vascular dilation, thereby…

In this feature article, we provide an overview of our research on statistical copolymers as a coating material for metal oxide nanoparticles and surfaces. These copolymers contain functional groups enabling non-covalent binding to oxide…

Soft Condensed Matter · Physics 2022-04-29 Jean-Francois Berret , Alain Graillot

Engineered inorganic nanoparticles are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases…

Materials Science · Physics 2011-08-25 M. Safi , J. Courtois , M. Seigneuret , H. Conjeaud , J. -F. Berret

Understanding the complex chemistry of functional nanomaterials is of fundamental importance. Controlled synthesis and characterization at the atomic level is essential to gain deeper insight into the unique chemical reactivity exhibited by…

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