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Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) to enhance lesion detection and characterisation, particularly in the field of neuro-oncology. Nevertheless, concerns regarding gadolinium…

Image and Video Processing · Electrical Eng. & Systems 2025-10-03 Pierre Fayolle , Alexandre Bône , Noëlie Debs , Philippe Robert , Pascal Bourdon , Remy Guillevin , David Helbert

Objective: Gadolinium-based contrast agents (GBCAs) are commonly used in MRI scans of patients with gliomas to enhance brain tumor characterization using T1-weighted (T1W) MRI. However, there is growing concern about GBCA toxicity. This…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Zach Eidex , Mojtaba Safari , Richard L. J. Qiu , David S. Yu , Hui-Kuo Shu , Hui Mao , Xiaofeng Yang

Contrast enhancement by Gadolinium-based contrast agents (GBCAs) is a vital tool for tumor diagnosis in neuroradiology. Based on brain MRI scans of glioblastoma before and after Gadolinium administration, we address enhancement prediction…

Image and Video Processing · Electrical Eng. & Systems 2024-10-14 Moritz Piening , Fabian Altekrüger , Gabriele Steidl , Elke Hattingen , Eike Steidl

Recently, deep learning (DL)-based methods have been proposed for the computational reduction of gadolinium-based contrast agents (GBCAs) to mitigate adverse side effects while preserving diagnostic value. Currently, the two main challenges…

Cerebral blood volume (CBV) is a hemodynamic correlate of oxygen metabolism and reflects brain activity and function. High-resolution CBV maps can be generated using the steady-state gadolinium-enhanced MRI technique. Such a technique…

Today Gadolinium-based contrast agents (GBCA) are indispensable in Magnetic Resonance Imaging (MRI) for diagnosing various diseases. However, GBCAs are expensive and may accumulate in patients with potential side effects, thus…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Thomas Pinetz , Erich Kobler , Robert Haase , Katerina Deike-Hofmann , Alexander Radbruch , Alexander Effland

Magnetic resonance imaging (MRI) is the most sensitive technique for breast cancer detection among current clinical imaging modalities. Contrast-enhanced MRI (CE-MRI) provides superior differentiation between tumors and invaded healthy…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Tianyu Zhang , Luyi Han , Anna D'Angelo , Xin Wang , Yuan Gao , Chunyao Lu , Jonas Teuwen , Regina Beets-Tan , Tao Tan , Ritse Mann

Complete and high-quality multi-modal Magnetic Resonance Imaging (MRI) is essential for accurate neuro-oncological assessment, as each contrast provides complementary anatomical and pathological information. However, acquiring all…

Image and Video Processing · Electrical Eng. & Systems 2026-05-04 Zaid A. Abod , Furqan Aziz

Objective: Gadolinium-based contrast agents (GBCAs) are commonly employed with T1w MRI to enhance lesion visualization but are restricted in patients at risk of nephrogenic systemic fibrosis and variations in GBCA administration can…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Zach Eidex , Mojtaba Safari , Jie Ding , Richard Qiu , Justin Roper , David Yu , Hui-Kuo Shu , Zhen Tian , Hui Mao , Xiaofeng Yang

Focused ultrasound (FUS) can be used to open the blood-brain barrier (BBB), and MRI with contrast agents can detect that opening. However, repeated use of gadolinium-based contrast agents (GBCAs) presents safety concerns to patients. This…

Quantitative Methods · Quantitative Biology 2023-01-19 P. Lee , H. Wei , A. N. Pouliopoulos , B. T. Forsyth , Y. Yang , C. Zhang , A. F. Laine , E. E. Konofagou , C. Wu , J. Guo

Gadolinium-based contrast agents (GBCAs) are central to glioma imaging but raise safety, cost, and accessibility concerns. Predicting contrast enhancement from non-contrast MRI using machine learning (ML) offers a safer alternative, as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Sajad Amiri , Shahram Taeb , Sara Gharibi , Setareh Dehghanfard , Somayeh Sadat Mehrnia , Mehrdad Oveisi , Ilker Hacihaliloglu , Arman Rahmim , Mohammad R. Salmanpour

Contrast-enhanced magnetic resonance imaging (MRI) is pivotal in the pipeline of brain tumor segmentation and analysis. Gadolinium-based contrast agents, as the most commonly used contrast agents, are expensive and may have potential side…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Lujun Gui , Chuyang Ye , Tianyi Yan

Contrast-enhanced magnetic resonance imaging (CE-MRI) is crucial for tumor detection and diagnosis, but the use of gadolinium-based contrast agents (GBCAs) in clinical settings raises safety concerns due to potential health risks. To…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Linhao Li , Changhui Su , Yu Guo , Huimao Zhang , Dong Liang , Kun Shang

Brain tumour imaging assessment typically requires both pre- and post-contrast MRI, but gadolinium administration is not always desirable, such as in frequent follow-up, renal impairment, allergy, or paediatric patients. We aimed to develop…

Compared to traditional methods, Deep Learning (DL) becomes a key technology for computer vision tasks. Synthetic data generation is an interesting use case for DL, especially in the field of medical imaging such as Magnetic Resonance…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Md Sumon Ali , Muzammil Behzad

Deep learning (DL) based contrast dose reduction and elimination in MRI imaging is gaining traction, given the detrimental effects of Gadolinium-based Contrast Agents (GBCAs). These DL algorithms are however limited by the availability of…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Dayang Wang , Srivathsa Pasumarthi , Greg Zaharchuk , Ryan Chamberlain

Every year thousands of patients are diagnosed with a glioma, a type of malignant brain tumor. Physicians use MR images as a key tool in the diagnosis and treatment of these patients. Neural networks show great potential to aid physicians…

Image and Video Processing · Electrical Eng. & Systems 2019-10-03 Eric Carver , Zhenzhen Dai , Evan Liang , James Snyder , Ning Wen

Generative Adversarial Networks (GAN) have shown potential in expanding limited medical imaging datasets. This study explores how different ratios of GAN-generated and real brain tumor MRI images impact the performance of a CNN in…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Mahin Montasir Afif , Abdullah Al Noman , K. M. Tahsin Kabir , Md. Mortuza Ahmmed , Md. Mostafizur Rahman , Mufti Mahmud , Md. Ashraful Babu

Magnetic resonance imaging (MRI) provides varying tissue contrast images of internal organs based on a strong magnetic field. Despite the non-invasive advantage of MRI in frequent imaging, the low contrast MR images in the target area make…

Image and Video Processing · Electrical Eng. & Systems 2020-06-11 Mohammad Hamghalam , Baiying Lei , Tianfu Wang

Convolutional Neural Networks (CNNs) achieve excellent computer-assisted diagnosis with sufficient annotated training data. However, most medical imaging datasets are small and fragmented. In this context, Generative Adversarial Networks…

Image and Video Processing · Electrical Eng. & Systems 2019-10-10 Changhee Han , Leonardo Rundo , Ryosuke Araki , Yudai Nagano , Yujiro Furukawa , Giancarlo Mauri , Hideki Nakayama , Hideaki Hayashi
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