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Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

A fundamental approach in neuroscience research is to test hypotheses based on neuropsychological and behavioral measures, i.e., whether certain factors (e.g., related to life events) are associated with an outcome (e.g., depression). In…

Machine Learning · Computer Science 2022-08-01 Magdalini Paschali , Qingyu Zhao , Ehsan Adeli , Kilian M. Pohl

While deep learning, including Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs), has significantly advanced classification performance, its typical reliance on extensive annotated datasets presents a major obstacle in…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Matheus Vinícius Todescato , Joel Luís Carbonera

Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Deep regression is an important problem with numerous applications. These range from computer vision tasks such as age estimation from photographs, to medical tasks such as ejection fraction estimation from echocardiograms for disease…

Computer Vision and Pattern Recognition · Computer Science 2023-02-16 Weihang Dai , Xiaomeng Li , Kwang-Ting Cheng

In neuroscience, understanding inter-individual differences has recently emerged as a major challenge, for which functional magnetic resonance imaging (fMRI) has proven invaluable. For this, neuroscientists rely on basic methods such as…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Akrem Sellami , François-Xavier Dupé , Bastien Cagna , Hachem Kadri , Stéphane Ayache , Thierry Artières , Sylvain Takerkart

Image classification systems recently made a giant leap with the advancement of deep neural networks. However, these systems require an excessive amount of labeled data to be adequately trained. Gathering a correctly annotated dataset is…

Machine Learning · Computer Science 2021-01-19 Görkem Algan , Ilkay Ulusoy

Alzheimer's Disease (AD) detection employs machine learning classification models to distinguish between individuals with AD and those without. Different from conventional classification tasks, we identify within-class variation as a…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-29 Jiawen Kang , Dongrui Han , Lingwei Meng , Jingyan Zhou , Jinchao Li , Xixin Wu , Helen Meng

Computer-aided diagnosis systems must make critical decisions from medical images that are often noisy, ambiguous, or conflicting, yet today's models are trained on overly simplistic labels that ignore diagnostic uncertainty. One-hot labels…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Ang Nan Gu , Michael Tsang , Hooman Vaseli , Purang Abolmaesumi , Teresa Tsang

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Alzheimer's disease (AD) has a complex and multifactorial etiology, which requires integrating information about neuroanatomy, genetics, and cerebrospinal fluid biomarkers for accurate diagnosis. Hence, recent deep learning approaches…

Machine Learning · Computer Science 2023-03-15 Tom Nuno Wolf , Sebastian Pölsterl , Christian Wachinger

Multimodal neuroimage can provide complementary information about the dementia, but small size of complete multimodal data limits the ability in representation learning. Moreover, the data distribution inconsistency from different…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Qiankun Zuo , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang

Semi-supervised learning algorithms reduce the high cost of acquiring labeled training data by using both labeled and unlabeled data during learning. Deep Convolutional Networks (DCNs) have achieved great success in supervised tasks and as…

Machine Learning · Statistics 2016-12-07 Tan Nguyen , Wanjia Liu , Ethan Perez , Richard G. Baraniuk , Ankit B. Patel

Tensor-based representations are being increasingly used to represent complex data types such as imaging data, due to their appealing properties such as dimension reduction and the preservation of spatial information. Recently, there is a…

Methodology · Statistics 2023-12-15 Rongke Lyu , Marina Vannucci , Suprateek Kundu

Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and…

Machine Learning · Statistics 2018-06-19 Shan Shi , Farouk Nathoo

There is an emerging trend to leverage noisy image datasets in many visual recognition tasks. However, the label noise among the datasets severely degenerates the \mbox{performance of deep} learning approaches. Recently, one mainstream is…

Computer Vision and Pattern Recognition · Computer Science 2017-11-03 Jiangchao Yao , Jiajie Wang , Ivor Tsang , Ya Zhang , Jun Sun , Chengqi Zhang , Rui Zhang

As the prevalence of Alzheimer's disease (AD) rises, improving mechanistic insight from non-invasive biomarkers is increasingly critical. Recent work suggests that circuit-level brain alterations manifest as changes in…

Neural and Evolutionary Computing · Computer Science 2026-02-10 Szymon Mamoń , Max Talanov , Alessandro Crimi

Diagnosing Autism Spectrum Disorder (ASD) is a challenging problem, and is based purely on behavioral descriptions of symptomology (DSM-5/ICD-10), and requires informants to observe children with disorder across different settings (e.g.…

Neurons and Cognition · Quantitative Biology 2020-03-04 Taban Eslami , Joseph S. Raiker , Fahad Saeed

Neuroimaging studies often involve the collection of multiple data modalities. These modalities contain both shared and mutually exclusive information about the brain. This work aims at finding a scalable and interpretable method to fuse…

Machine Learning · Computer Science 2021-05-05 Eloy Geenjaar , Noah Lewis , Zening Fu , Rohan Venkatdas , Sergey Plis , Vince Calhoun
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