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Domain generalization in computational histopathology is hindered by heterogeneity in whole slide images (WSIs), caused by variations in tissue preparation, staining, and imaging conditions across institutions. Unlike machine learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Hikmat Khan , Syed Farhan Alam Zaidi , Pir Masoom Shah , Kiruthika Balakrishnan , Rabia Khan , Muhammad Waqas , Jia Wu

Machine learning algorithms have revolutionized different fields, including natural language processing, computer vision, signal processing, and medical data processing. Despite the excellent capabilities of machine learning algorithms in…

Image and Video Processing · Electrical Eng. & Systems 2022-12-07 Gita Sarafraz , Armin Behnamnia , Mehran Hosseinzadeh , Ali Balapour , Amin Meghrazi , Hamid R. Rabiee

We have tested recently published foundation models for histopathology for image retrieval. We report macro average of F1 score for top-1 retrieval, majority of top-3 retrievals, and majority of top-5 retrievals. We perform zero-shot…

Image and Video Processing · Electrical Eng. & Systems 2024-09-13 Saghir Alfasly , Ghazal Alabtah , Sobhan Hemati , Krishna Rani Kalari , H. R. Tizhoosh

Machine learning-based Android malware detectors often fail in real-world deployment due to domain shift, where models trained on one data source perform poorly on applications from another. This paper presents a comprehensive study on the…

Machine Learning · Computer Science 2026-05-15 Md Rafid Islam

Performance on benchmark datasets has drastically improved with advances in deep learning. Still, cross-dataset generalization performance remains relatively low due to the domain shift that can occur between two different datasets. This…

Computer Vision and Pattern Recognition · Computer Science 2019-01-08 Alexandra Carlson , Katherine A. Skinner , Ram Vasudevan , Matthew Johnson-Roberson

Due to the recent advancements in machine vision, digital pathology has gained significant attention. Histopathology images are distinctly rich in visual information. The tissue glass slide images are utilized for disease diagnosis.…

Image and Video Processing · Electrical Eng. & Systems 2020-11-02 Danial Maleki , Mehdi Afshari , Morteza Babaie , H. R. Tizhoosh

Medical image analysis (MedIA) has become an essential tool in medicine and healthcare, aiding in disease diagnosis, prognosis, and treatment planning, and recent successes in deep learning (DL) have made significant contributions to its…

Image and Video Processing · Electrical Eng. & Systems 2024-12-10 Jee Seok Yoon , Kwanseok Oh , Yooseung Shin , Maciej A. Mazurowski , Heung-Il Suk

In recent years, numerous domain adaptive strategies have been proposed to help deep learning models overcome the challenges posed by domain shift. However, even unsupervised domain adaptive strategies still require a large amount of target…

Image and Video Processing · Electrical Eng. & Systems 2024-07-11 Sumayya Inayat , Nimra Dilawar , Waqas Sultani , Mohsen Ali

Whole slide images (WSIs) pose unique challenges when training deep learning models. They are very large which makes it necessary to break each image down into smaller patches for analysis, image features have to be extracted at multiple…

Image and Video Processing · Electrical Eng. & Systems 2020-12-02 Ozan Ciga , Tony Xu , Sharon Nofech-Mozes , Shawna Noy , Fang-I Lu , Anne L. Martel

The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

Image and Video Processing · Electrical Eng. & Systems 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

Deep learning models have exhibited exceptional effectiveness in Computational Pathology (CPath) by tackling intricate tasks across an array of histology image analysis applications. Nevertheless, the presence of out-of-distribution data…

Image and Video Processing · Electrical Eng. & Systems 2023-10-31 Mostafa Jahanifar , Manahil Raza , Kesi Xu , Trinh Vuong , Rob Jewsbury , Adam Shephard , Neda Zamanitajeddin , Jin Tae Kwak , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

In machine learning, research has traditionally focused on model development, with relatively less attention paid to training data. As model architectures have matured and marginal gains from further refinements diminish, data quality has…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Pei-Han Chen , Szu-Chi Chung

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo

Multi-source CT-scan classification suffers from domain shifts that impair cross-source generalization. While preprocessing pipelines combining Spatial-Slice Feature Learning (SSFL++) and Kernel-Density-based Slice Sampling (KDS) have shown…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Chia-Ming Lee , Bo-Cheng Qiu , Ting-Yao Chen , Ming-Han Sun , Fang-Ying Lin , Jung-Tse Tsai , I-An Tsai , Yu-Fan Lin , Chih-Chung Hsu

While Wi-Fi sensing offers a compelling, privacy-preserving alternative to cameras, its practical utility has been fundamentally undermined by a lack of robustness across domains. Models trained in one setup fail to generalize to new…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Cheng Jiang , Yihe Yan , Yanxiang Wang , Chun Tung Chou , Wen Hu

Both limited annotation and domain shift are prevalent challenges in medical image segmentation. Traditional semi-supervised segmentation and unsupervised domain adaptation methods address one of these issues separately. However, the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-02 Qinghe Ma , Jian Zhang , Lei Qi , Qian Yu , Yinghuan Shi , Yang Gao

The automated analysis of medical images is currently limited by technical and biological noise and bias. The same source tissue can be represented by vastly different images if the image acquisition or processing protocols vary. For an…

Atypical mitotic figures (AMFs) are clinically relevant indicators of abnormal cell division, yet their reliable detection remains challenging due to morphological ambiguity and scanner variability. In this work, we investigated three…

Image and Video Processing · Electrical Eng. & Systems 2025-09-08 Biwen Meng , Xi Long , Jingxin Liu

Background and objective: Employing deep learning models in critical domains such as medical imaging poses challenges associated with the limited availability of training data. We present a strategy for improving the performance and…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Eva Pachetti , Sotirios A. Tsaftaris , Sara Colantonio

The MIDOG 2025 challenge extends prior work on mitotic figure detection by introducing a new Track 2 on atypical mitosis classification. This task aims to distinguish normal from atypical mitotic figures in histopathology images, a…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Leire Benito-Del-Valle , Pedro A. Moreno-Sánchez , Itziar Egusquiza , Itsaso Vitoria , Artzai Picón , Cristina López-Saratxaga , Adrian Galdran