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AlphaFold 3 represents a transformative advancement in computational biology, enhancing protein structure prediction through novel multi-scale transformer architectures, biologically informed cross-attention mechanisms, and geometry-aware…

Biomolecules · Quantitative Biology 2025-08-27 Alireza Abbaszadeh , Armita Shahlaee

This paper proposes a novel neural-network-based adaptive hybrid-reflectance three-dimensional (3-D) surface reconstruction model. The neural network combines the diffuse and specular components into a hybrid model. The proposed model…

Neural and Evolutionary Computing · Computer Science 2009-12-14 Vincy Joseph , Shalini Bhatia

We propose a new multi-scale molecular dynamics simulation method which can achieve high accuracy and high sampling efficiency simultaneously without aforehand knowledge of the coarse grained (CG) potential and test it for a biomolecular…

Biological Physics · Physics 2009-08-05 Wenfei Li , Shoji Takada

Deep learning models usually require sufficient training data to achieve high accuracy, but obtaining labeled data can be time-consuming and labor-intensive. Here we introduce a template-based training method to train a 3D U-Net model from…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Fang-Cheng Yeh

Deep convolutional neural networks are powerful tools for learning visual representations from images. However, designing efficient deep architectures to analyse volumetric medical images remains challenging. This work investigates…

Computer Vision and Pattern Recognition · Computer Science 2017-07-10 Wenqi Li , Guotai Wang , Lucas Fidon , Sebastien Ourselin , M. Jorge Cardoso , Tom Vercauteren

Accurate models are essential for design, performance prediction, control, and diagnostics in complex engineering systems. Physics-based models excel during the design phase but often become outdated during system deployment due to changing…

Machine Learning · Computer Science 2025-01-22 Zihan Liu , Prashant N. Kambali , C. Nataraj

3D brain MRI studies often examine subtle morphometric differences between cohorts that are hard to detect visually. Given the high cost of MRI acquisition, these studies could greatly benefit from image syntheses, particularly…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Binxu Li , Wei Peng , Mingjie Li , Ehsan Adeli , Kilian M. Pohl

A well-trained deep neural network is shown to gain capability of simultaneously restoring two kinds of images, which are completely destroyed by two distinct scattering medias respectively. The network, based on the U-net architecture, can…

Image and Video Processing · Electrical Eng. & Systems 2019-02-21 Mu Yang , Zheng-Hao Liu , Ze-Di Cheng , Jin-Shi Xu , Chuan-Feng Li , Guang-Can Guo

We present a novel method for characterizing the microstructure of a material from volumetric datasets such as 3D image data from computed tomography (CT). The method is based on a new statistical model for the distribution of voxel…

Materials Science · Physics 2021-01-06 Elise Otterlei Brenne , Vedrana Andersen Dahl , Peter Stanley Jørgensen

Recovering textured 3D models of non-rigid human body shapes is challenging due to self-occlusions caused by complex body poses and shapes, clothing obstructions, lack of surface texture, background clutter, sparse set of cameras with…

Computer Vision and Pattern Recognition · Computer Science 2018-09-19 Abbhinav Venkat , Sai Sagar Jinka , Avinash Sharma

Multi-organ segmentation of 3D medical images is fundamental with meaningful applications in various clinical automation pipelines. Although deep learning has achieved superior performance, the time and memory consumption of segmenting the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Xueqi Guo , Halid Ziya Yerebakan , Yoshihisa Shinagawa , Kritika Iyer , Gerardo Hermosillo Valadez

Phase retrieval aims to recover a signal from intensity-only measurements, a fundamental problem in many fields such as imaging, holography, optical computing, crystallography, and microscopy. Although there are several well-known phase…

Image and Video Processing · Electrical Eng. & Systems 2026-01-21 Mehmet Onurcan Kaya , Figen S. Oktem

The recent development of deep learning large models in medicine shows remarkable performance in medical image analysis and diagnosis, but their large number of parameters causes memory and inference latency challenges. Knowledge…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Shaojie Li , Zhaoshuo Diao

Understanding material surfaces and interfaces is vital in applications like catalysis or electronics. By combining energies from electronic structure with statistical mechanics, ab initio simulations can in principle predict the structure…

Traditional numerical methods often struggle with the complexity and scale of modeling pollutant transport across vast and dynamic oceanic domains. This paper introduces a Physics-Informed Neural Network (PINN) framework to simulate the…

Machine Learning · Computer Science 2025-07-15 Karishma Battina , Prathamesh Dinesh Joshi , Raj Abhijit Dandekar , Rajat Dandekar , Sreedath Panat

As AI-generated images become increasingly photorealistic, distinguishing them from natural images poses a growing challenge. This paper presents a robust detection framework that leverages multiple uncertainty measures to decide whether to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Rahul Yumlembam , Biju Issac , Nauman Aslam , Eaby Kollonoor Babu , Josh Collyer , Fraser Kennedy

Segment Anything Model (SAM) fine-tuning has shown remarkable performance in medical image segmentation in a fully supervised manner, but requires precise annotations. To reduce the annotation cost and maintain satisfactory performance, in…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Shumeng Li , Lei Qi , Qian Yu , Jing Huo , Yinghuan Shi , Yang Gao

We present feature finding and tracking algorithms in 3D in living cells, and demonstrate their utility to measure metrics important in cell biological processes. We developed a computational imaging hybrid approach that combines automated…

Biological Physics · Physics 2015-04-06 Kemp Plumb , Sarah Elaz , Vincent Pelletier , Maria L. Kilfoil

Positron Emission Tomography (PET) is an important molecular imaging tool widely used in medicine. Traditional PET systems rely on complete detector rings for full angular coverage and reliable data collection. However, incomplete-ring PET…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Yeqi Fang , Rong Zhou

Training deep neural networks on large and sparse datasets is still challenging and can require large amounts of computation and memory. In this work, we address the task of performing semantic segmentation on large volumetric data sets,…

Computer Vision and Pattern Recognition · Computer Science 2018-07-09 Lorenz Berger , Eoin Hyde , Matt Gibb , Nevil Pavithran , Garin Kelly , Faiz Mumtaz , Sébastien Ourselin