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Successive whole genome duplications have recently been firmly established in all major eukaryote kingdoms. It is not clear, however, how such dramatic evolutionary process has contributed to shape the large scale topology of…

Molecular Networks · Quantitative Biology 2007-05-23 K. Evlampiev , H. Isambert

We are flooded with large-scale dynamic networked data. Analyses requiring exact comparisons between networks are computationally intractable, so new methodologies are sought. We extend the graphlet-based statistics to directed networks and…

Social and Information Networks · Computer Science 2016-03-18 Anida Sarajlić , Noël Malod-Dognin , Ömer Nebil Yaveroğlu , Nataša Pržulj

Experimental results often do not assess network structure; rather, the network structure is inferred by the dynamics of the nodes. From the dynamics of the nodes one then constructs a network of functional relations, termed the functional…

Adaptation and Self-Organizing Systems · Physics 2017-11-22 Jake Stroud , Mauricio Barahona , Tiago Pereira

Uncovering structural patterns in collaboration networks is key for understanding how knowledge flows and innovation emerges. These networks often exhibit a rich interplay of meso-scale structures, such as communities, core-periphery…

Methodology · Statistics 2025-11-25 Sara Geremia , Domenico De Stefano , Michael Fop

An essential step toward understanding neural circuits is linking their structure and their dynamics. In general, this relationship can be almost arbitrarily complex. Recent theoretical work has, however, begun to identify some broad…

Neurons and Cognition · Quantitative Biology 2017-03-10 Gabriel Koch Ocker , Yu Hu , Michael A. Buice , Brent Doiron , Krešimir Josić , Robert Rosenbaum , Eric Shea-Brown

Understanding brain connectivity has become one of the most important issues in neuroscience. But connectivity data can reflect either the functional relationships of the brain activities or the anatomical properties between brain areas.…

Neurons and Cognition · Quantitative Biology 2015-04-13 Tiago Simas , Mario Chavez , Pablo Rodriguez , Albert Diaz-Guilera

So far, many network-structure-based link prediction methods have been proposed. However, these methods only highlight one or two structural features of networks, and then use the methods to predict missing links in different networks. The…

Physics and Society · Physics 2017-09-01 Chuang Ma , Zhong-Kui Bao , Hai-Feng Zhang

A collaboration network is a graph formed by communication channels between parties. Parties communicate over these channels to establish secrets, simultaneously enforcing interdependencies between the secrets. The paper studies properties…

Logic in Computer Science · Computer Science 2010-11-02 Sara Miner More , Pavel Naumov

Real-world networks often benefit from capturing both local and global interactions. Inspired by multi-modal analysis in brain imaging, where structural and functional connectivity offer complementary views of network organization, we…

Neural and Evolutionary Computing · Computer Science 2025-08-11 Yang Li , Luopeiwen Yi , Tananun Songdechakraiwut

The structure of complex networks has been of interest in many scientific and engineering disciplines over the decades. A number of studies in the field have been focused on finding the common properties among different kinds of networks…

Social and Information Networks · Computer Science 2017-11-01 Kansuke Ikehara , Aaron Clauset

The properties of complex networked systems arise from the interplay between the dynamics of their elements and the underlying topology. Thus, to understand their behaviour, it is crucial to convene as much information as possible about…

Neurons and Cognition · Quantitative Biology 2024-06-18 Gustavo Menesse , Akke Mats Houben , Jordi Soriano , Joaquin J. Torres

Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand…

Molecular Networks · Quantitative Biology 2015-05-21 Sriganesh Srihari , Chern Han Yong , Ashwini Patil , Limsoon Wong

Functional connectivity (FC) refers to the investigation of interactions between brain regions to understand integration of neural activity in several regions. FC is often estimated using functional magnetic resonance images (fMRI). There…

Applications · Statistics 2023-01-24 Nathan Tung , Jerome Sanes , Eli Upfal , Ani Eloyan

Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…

Machine Learning · Computer Science 2025-10-23 Xinzhe Zheng , Hao Du , Fanding Xu , Jinzhe Li , Zhiyuan Liu , Wenkang Wang , Tao Chen , Wanli Ouyang , Stan Z. Li , Yan Lu , Nanqing Dong , Yang Zhang

Protein-protein interaction (PPI) networks, providing a comprehensive landscape of protein interacting patterns, enable us to explore biological processes and cellular components at multiple resolutions. For a biological process, a number…

Molecular Networks · Quantitative Biology 2016-04-13 Xiuli Ma , Guangyu Zhou , Jingjing Wang , Jian Peng , Jiawei Han

We consider an alternate definition of community structure that is functionally motivated. We define network community structure-based on the function the network system is intended to perform. In particular, as a specific example of this…

Physics and Society · Physics 2015-03-13 Sanjeev Chauhan , Michelle Girvan , Edward Ott

Social and professional networks affect labor market dynamics, knowledge diffusion and new business creation. To understand the determinants of how these networks are formed in the first place, we analyze a unique dataset of business cards…

Econometrics · Economics 2021-08-04 Juan Nelson Martínez Dahbura , Shota Komatsu , Takanori Nishida , Angelo Mele

The protein-protein interaction (PPI) network provides an overview of the complex biological reactions vital to an organism's metabolism and survival. Even though in the past PPI network were compared across organisms in detail, there has…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Long-Huei Chen , Mohana Prasad Sathya Moorthy , Pratyaksh Sharma

The contribution of structural connectivity to functional brain states remains poorly understood. We present a mathematical and computational study suited to assess the structure--function issue, treating a system of Jansen--Rit neural-mass…

Neurons and Cognition · Quantitative Biology 2020-07-10 Michael Forrester , Stephen Coombes , Jonathan J. Crofts , Stamatios N. Sotiropoulos , Reuben D. O'Dea

Interactions between units in phyical, biological, technological, and social systems usually give rise to intrincate networks with non-trivial structure, which critically affects the dynamics and properties of the system. The focus of most…

Data Analysis, Statistics and Probability · Physics 2007-05-23 R. Guimera , M. Sales-Pardo , L. A. N. Amaral