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Mass spectrometry provides a high-throughput way to identify proteins in biological samples. In a typical experiment, proteins in a sample are first broken into their constituent peptides. The resulting mixture of peptides is then subjected…

Applications · Statistics 2010-11-10 Qunhua Li , Michael J. MacCoss , Matthew Stephens

First-order optimization methods have attracted a lot of attention due to their practical success in many applications, including in machine learning. Obtaining convergence guarantees and worst-case performance certificates for first-order…

Optimization and Control · Mathematics 2023-10-04 Baptiste Goujaud , Aymeric Dieuleveut , Adrien Taylor

Consider a finite set of sources, each producing i.i.d. observations that follow a unique probability distribution on a finite alphabet. We study the problem of matching a finite set of observed sequences to the set of sources under the…

Information Theory · Computer Science 2014-12-09 Jayakrishnan Unnikrishnan

In this paper, we introduce new stable mixed finite elements of any order on polytopal mesh for solving second order elliptic problem. We establish optimal order error estimates for velocity and super convergence for pressure. Numerical…

Numerical Analysis · Mathematics 2020-09-14 Yanping Lin , Xiu Ye , Shangyou Zhang

In this paper we consider the problem of detecting statistically significant sequential patterns in multi-neuronal spike trains. These patterns are characterized by ordered sequences of spikes from different neurons with specific delays…

Neurons and Cognition · Quantitative Biology 2008-08-28 P. S. Sastry , K. P. Unnikrishnan

We derive a new high-order compact finite difference scheme for option pricing in stochastic volatility models. The scheme is fourth-order accurate in space and second-order accurate in time. Under some restrictions, theoretical results…

Computational Finance · Quantitative Finance 2014-04-23 Bertram Düring , Michel Fournié

We provide a novel computer-assisted technique for systematically analyzing first-order methods for optimization. In contrast with previous works, the approach is particularly suited for handling sublinear convergence rates and stochastic…

Optimization and Control · Mathematics 2021-12-22 Adrien Taylor , Francis Bach

The study of combinations of drugs/drug-schedules gained increasing attention in various therapeutic areas recently. In oncology, the aim of phase I combination clinical trial is to find the maximum tolerated combination (MTC). Many…

Methodology · Statistics 2025-05-09 Weishi Chen , Pavel Mozgunov

In this paper, we study the problem of learning one-dimensional Gaussian mixture models (GMMs) with a specific focus on estimating both the model order and the mixing distribution from independent and identically distributed (i.i.d.)…

Machine Learning · Statistics 2026-02-24 Xinyu Liu , Hai Zhang

Chain-of-thought (CoT) reasoning with self-consistency improves performance by aggregating multiple sampled reasoning paths. In this setting, correctness is no longer tied to a single reasoning trace but to the aggregation rule over a pool…

Machine Learning · Statistics 2026-05-15 Yu Gu , Zijun Yu , Vahid Partovi Nia , Masoud Asgharian

Sequential tests and their implied confidence sequences, which are valid at arbitrary stopping times, promise flexible statistical inference and on-the-fly decision making. However, strong guarantees are limited to parametric sequential…

Methodology · Statistics 2024-03-12 Aurelien Bibaut , Nathan Kallus , Michael Lindon

In some situations, EM algorithm shows slow convergence problems. One possible reason is that standard procedures update the parameters simultaneously. In this paper we focus on finite mixture estimation. In this framework, we propose a…

Computation · Statistics 2012-01-31 Gilles Celeux , Stéphane Chrétien , Florence Forbes

Hypothesis testing methods that do not rely on exact distribution assumptions have been emerging lately. The method of sign-perturbed sums (SPS) is capable of characterizing confidence regions with exact confidence levels for linear…

Systems and Control · Computer Science 2017-07-03 Sándor Kolumbán , István Vajk , Johan Schoukens

Stability selection is a popular method for improving feature selection algorithms. One of its key attributes is that it provides theoretical upper bounds on the expected number of false positives, E(FP), enabling false positive control in…

Methodology · Statistics 2025-07-18 Omar Melikechi , Jeffrey W. Miller

The theory part of this paper is sketched as follows. Based on column stochastic average matrix $T_n$ selected as a basic substitution matrix, the method of advanced successive difference substitution is established. Then, a set of…

Symbolic Computation · Computer Science 2010-04-05 Yong Yao

Modern parcel logistic networks are designed to ship demand between given origin, destination pairs of nodes in an underlying directed network. Efficiency dictates that volume needs to be consolidated at intermediate nodes in typical…

Discrete Mathematics · Computer Science 2023-11-10 Madison Van Dyk , Kim Klause , Jochen Koenemann , Nicole Megow

We present a bounded model checking algorithm for signal temporal logic (STL) that exploits mixed-integer linear programming (MILP). A key technical element is our novel MILP encoding of the STL semantics; it follows the idea of stable…

Systems and Control · Electrical Eng. & Systems 2024-08-14 Sota Sato , Jie An , Zhenya Zhang , Ichiro Hasuo

Stochastic ordering among distributions has been considered in a variety of scenarios. Economic studies often involve research about the ordering of investment strategies or social welfare. However, as noted in the literature, stochastic…

Despite the success of model predictive control (MPC), its application to high-dimensional systems, such as flexible structures and coupled fluid/rigid-body systems, remains a largely open challenge due to excessive computational…

Systems and Control · Computer Science 2019-05-03 Joseph Lorenzetti , Benoit Landry , Sumeet Singh , Marco Pavone

In this paper, new contributions to requirements-based testing with deterministic finite state machines are presented. Elementary requirements are specified as triples consisting of a state in the reference model, an input, and the expected…

Software Engineering · Computer Science 2021-05-26 Wen-ling Huang , Jan Peleska