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Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

Computer Vision and Pattern Recognition · Computer Science 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Accurate medical image segmentation is essential for diagnosis and treatment planning of diseases. Convolutional Neural Networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they are…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Ran Gu , Guotai Wang , Tao Song , Rui Huang , Michael Aertsen , Jan Deprest , Sébastien Ourselin , Tom Vercauteren , Shaoting Zhang

We propose an end-to-end Multitask Learning Transformer framework, named MulT, to simultaneously learn multiple high-level vision tasks, including depth estimation, semantic segmentation, reshading, surface normal estimation, 2D keypoint…

Computer Vision and Pattern Recognition · Computer Science 2022-05-18 Deblina Bhattacharjee , Tong Zhang , Sabine Süsstrunk , Mathieu Salzmann

In recent years, attention mechanisms have been exploited in single image super-resolution (SISR), achieving impressive reconstruction results. However, these advancements are still limited by the reliance on simple training strategies and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Yuxuan Jiang , Chengxi Zeng , Siyue Teng , Fan Zhang , Xiaoqing Zhu , Joel Sole , David Bull

Multiple instance learning (MIL)-based framework has become the mainstream for processing the whole slide image (WSI) with giga-pixel size and hierarchical image context in digital pathology. However, these methods heavily depend on a…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Jiangbo Shi , Chen Li , Tieliang Gong , Yefeng Zheng , Huazhu Fu

Deep clustering has shown its promising capability in joint representation learning and clustering via deep neural networks. Despite the significant progress, the existing deep clustering works mostly utilize some distribution-based…

Computer Vision and Pattern Recognition · Computer Science 2023-10-18 Yuankun Xu , Dong Huang , Chang-Dong Wang , Jian-Huang Lai

Given the special situation of modeling gigapixel images, multiple instance learning (MIL) has become one of the most important frameworks for Whole Slide Image (WSI) classification. In current practice, most MIL networks often face two…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Pei Liu , Luping Ji , Xinyu Zhang , Feng Ye

Automatic instance segmentation of glomeruli within kidney Whole Slide Imaging (WSI) is essential for clinical research in renal pathology. In computer vision, the end-to-end instance segmentation methods (e.g., Mask-RCNN) have shown their…

Image and Video Processing · Electrical Eng. & Systems 2020-07-08 Aadarsh Jha , Haichun Yang , Ruining Deng , Meghan E. Kapp , Agnes B. Fogo , Yuankai Huo

Hyperspectral image (HSI) classification faces critical challenges, including high spectral dimensionality, complex spectral-spatial correlations, and limited training samples with severe class imbalance. While CNNs excel at local feature…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Asmit Bandyopadhyay , Anindita Das Bhattacharjee , Rakesh Das

Whole Slide Imaging (WSI) has become an important topic during the last decade. Even though significant progress in both medical image processing and computational resources has been achieved, there are still problems in WSI that need to be…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Wafa Chenni , Habib Herbi , Morteza Babaie , H. R. Tizhoosh

High-dimensional and complex spectral structures make the clustering of hyperspectral images (HSI) a challenging task. Subspace clustering is an effective approach for addressing this problem. However, current subspace clustering algorithms…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Renxiang Guan , Zihao Li , Xianju Li , Chang Tang , Ruyi Feng

Image clustering is one of the crucial techniques in multimedia analytics and knowledge discovery. Recently, the Deep clustering method (DC), characterized by its ability to perform feature learning and cluster assignment jointly, surpasses…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haiyang Zheng , Ruilin Zhang , Hongpeng Wang

Whole-slide image (WSI) analysis is challenging due to the gigapixel scale of slides and their inherent hierarchical multi-resolution structure. Existing multiple instance learning (MIL) approaches often model WSIs as unordered collections…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Dongqing Xie , Yonghuang Wu

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance…

Computer Vision and Pattern Recognition · Computer Science 2024-10-21 Honglin Li , Yunlong Zhang , Pingyi Chen , Zhongyi Shui , Chenglu Zhu , Lin Yang

We present a novel clustering objective that learns a neural network classifier from scratch, given only unlabelled data samples. The model discovers clusters that accurately match semantic classes, achieving state-of-the-art results in…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Xu Ji , João F. Henriques , Andrea Vedaldi

Attention-based multiple instance learning (MIL) has emerged as a powerful framework for whole slide image (WSI) diagnosis, leveraging attention to aggregate instance-level features into bag-level predictions. Despite this success, we find…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Linfeng Ye , Shayan Mohajer Hamidi , Zhixiang Chi , Guang Li , Mert Pilanci , Takahiro Ogawa , Miki Haseyama , Konstantinos N. Plataniotis

Since the emergence of the ImageNet dataset, the pretraining and fine-tuning approach has become widely adopted in computer vision due to the ability of ImageNet-pretrained models to learn a wide variety of visual features. However, a…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Pablo Meseguer , Rocío del Amor , Adrian Colomer , Valery Naranjo

Machine learning in computational pathology (CPath) often aggregates patch-level predictions from multi-gigapixel Whole Slide Images (WSIs) to generate WSI-level prediction scores for crucial tasks such as survival prediction and drug…

Machine Learning · Computer Science 2025-12-29 Piotr Keller , Muhammad Dawood , Brinder Singh Chohan , Fayyaz ul Amir Afsar Minhas

The survival analysis on histological whole-slide images (WSIs) is one of the most important means to estimate patient prognosis. Although many weakly-supervised deep learning models have been developed for gigapixel WSIs, their potential…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Pei Liu , Luping Ji , Feng Ye , Bo Fu

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He