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Deep kernel learning provides an elegant and principled framework for combining the structural properties of deep learning algorithms with the flexibility of kernel methods. By means of a deep neural network, we learn a parametrized kernel…

Machine Learning · Computer Science 2020-12-14 Prudencio Tossou , Basile Dura , Francois Laviolette , Mario Marchand , Alexandre Lacoste

Conformal unlearning aims to ensure that a trained conformal predictor miscovers data points with specific shared characteristics, such as those from a particular label class, associated with a specific user, or belonging to a defined…

Machine Learning · Computer Science 2026-02-13 Yahya Alkhatib , Muhammad Ahmar Jamal , Wee Peng Tay

Unsupervised Re-ID methods aim at learning robust and discriminative features from unlabeled data. However, existing methods often ignore the relationship between module parameters of Re-ID framework and feature distributions, which may…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Ziqi He , Mengjia Xue , Yunhao Du , Zhicheng Zhao , Fei Su

Detecting the emergence of abrupt property changes in time series is a challenging problem. Kernel two-sample test has been studied for this task which makes fewer assumptions on the distributions than traditional parametric approaches.…

Machine Learning · Statistics 2019-01-21 Wei-Cheng Chang , Chun-Liang Li , Yiming Yang , Barnabás Póczos

T cells are central to the adaptive immune response, capable of detecting pathogenic antigens while ignoring healthy tissues with remarkable specificity and sensitivity. Quantitatively understanding how T cell receptors (TCRs) discriminate…

Molecular Networks · Quantitative Biology 2025-11-25 François X. P. Bourassa , Sooraj Achar , Grégoire Altan-Bonnet , Paul François

The receptive field (RF), which determines the region of time series to be ``seen'' and used, is critical to improve the performance for time series classification (TSC). However, the variation of signal scales across and within time series…

Machine Learning · Computer Science 2022-12-21 Qiao Xiao , Boqian Wu , Yu Zhang , Shiwei Liu , Mykola Pechenizkiy , Elena Mocanu , Decebal Constantin Mocanu

Learning useful data representations without requiring labels is a cornerstone of modern deep learning. Self-supervised learning methods, particularly contrastive learning (CL), have proven successful by leveraging data augmentations to…

Machine Learning · Computer Science 2023-12-11 Sacha Morin , Somjit Nath , Samira Ebrahimi Kahou , Guy Wolf

The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptors and ligands has made it challenging to discover…

Classifier ensemble generally should combine diverse component classifiers. However, it is difficult to give a definitive connection between diversity measure and ensemble accuracy. Given a list of available component classifiers, how to…

Machine Learning · Computer Science 2014-06-06 Xu-Cheng Yin , Chun Yang , Hong-Wei Hao

Many common clustering methods cannot be used for clustering multivariate longitudinal data in cases where variables exhibit high autocorrelations. In this article, a copula kernel mixture model (CKMM) is proposed for clustering data of…

Methodology · Statistics 2025-06-23 Xi Zhang , Orla A. Murphy , Paul D. McNicholas

The recent breakthrough achieved by contrastive learning accelerates the pace for deploying unsupervised training on real-world data applications. However, unlabeled data in reality is commonly imbalanced and shows a long-tail distribution,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Ziyu Jiang , Tianlong Chen , Bobak Mortazavi , Zhangyang Wang

Identifying T-cell receptors (TCRs) that interact with antigenic peptides provides the technical basis for developing vaccines and immunotherapies. The emergent deep learning methods excel at learning antigen binding patterns from known…

Quantitative Methods · Quantitative Biology 2024-11-28 Jiangbin Zheng , Qianhui Xu , Ruichen Xia , Stan Z. Li

Several statistical approaches based on reproducing kernels have been proposed to detect abrupt changes arising in the full distribution of the observations and not only in the mean or variance. Some of these approaches enjoy good…

Statistics Theory · Mathematics 2017-10-13 Alain Celisse , Guillemette Marot , Morgane Pierre-Jean , Guillem Rigaill

We report DynaCLR, a self-supervised method for embedding cell and organelle Dynamics via Contrastive Learning of Representations of time-lapse images. DynaCLR integrates single-cell tracking and time-aware contrastive sampling to learn…

In this paper, we propose Complex Diffusion Maps (CDM), a novel diffusion mapping framework that aims to reveal the dominant complex harmonics of high-dimensional data. Inspired by the local Gaussian kernel relevant to the heat equation and…

Machine Learning · Computer Science 2026-05-05 Tongzhen Dang , Weiyang Ding , Michael K. Ng

Conformal inference is a method that provides prediction sets for machine learning models, operating independently of the underlying distributional assumptions and relying solely on the exchangeability of training and test data. Despite its…

Methodology · Statistics 2025-10-01 Daniela Corbetta , Livio Finos , Ludwig Geistlinger , Davide Risso

Dynamic treatment regimes (DTRs) are used in medicine to tailor sequential treatment decisions to patients by considering patient heterogeneity. Common methods for learning optimal DTRs, however, have shortcomings: they are typically based…

Machine Learning · Statistics 2023-06-21 Theresa Blümlein , Joel Persson , Stefan Feuerriegel

Online change detection involves monitoring a stream of data for changes in the statistical properties of incoming observations. A good change detector will detect any changes shortly after they occur, while raising few false alarms.…

Statistics Theory · Mathematics 2020-03-03 Thomas Flynn , Shinjae Yoo

Domain specific (dis-)similarity or proximity measures used e.g. in alignment algorithms of sequence data, are popular to analyze complex data objects and to cover domain specific data properties. Without an underlying vector space these…

Data Structures and Algorithms · Computer Science 2014-11-07 Andrej Gisbrecht , Frank-Michael Schleif

The medical research facilitates to acquire a diverse type of data from the same individual for particular cancer. Recent studies show that utilizing such diverse data results in more accurate predictions. The major challenge faced is how…

Genomics · Quantitative Biology 2017-10-11 Jaya Thomas , Lee Sael
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