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Knowledge Graphs have been one of the fundamental methods for integrating heterogeneous data sources. Integrating heterogeneous data sources is crucial, especially in the biomedical domain, where central data-driven tasks such as drug…

Machine Learning · Computer Science 2020-12-22 Islam Akef Ebeid , Majdi Hassan , Tingyi Wanyan , Jack Roper , Abhik Seal , Ying Ding

Multi-hop reasoning (MHR) is a process in artificial intelligence and natural language processing where a system needs to make multiple inferential steps to arrive at a conclusion or answer. In the context of knowledge graphs or databases,…

Artificial Intelligence · Computer Science 2024-06-13 Jesmin Jahan Tithi , Fabio Checconi , Fabrizio Petrini

Knowledge graphs represent facts about real-world entities. Most of these facts are defined as positive statements. The negative statements are scarce but highly relevant under the open-world assumption. Furthermore, they have been…

Artificial Intelligence · Computer Science 2023-11-16 Rita T. Sousa , Sara Silva , Catia Pesquita

Explainability and effectiveness are two key aspects for building recommender systems. Prior efforts mostly focus on incorporating side information to achieve better recommendation performance. However, these methods have some weaknesses:…

Information Retrieval · Computer Science 2019-03-12 Weizhi Ma , Min Zhang , Yue Cao , Woojeong , Jin , Chenyang Wang , Yiqun Liu , Shaoping Ma , Xiang Ren

In domains where transparency and trustworthiness are crucial, such as healthcare, rule-based systems are widely used and often preferred over black-box models for decision support systems due to their inherent interpretability. However, as…

Machine Learning · Computer Science 2025-06-18 Christel Sirocchi , Damiano Verda

Clinical evidence encompasses the associations and impacts between patients, interventions (such as drugs or physiotherapy), problems, and outcomes. The goal of recommending clinical evidence is to provide medical practitioners with…

Computation and Language · Computer Science 2023-04-05 Maolin Luo , Xiang Zhang

Knowledge graphs are an expressive and widely used data structure due to their ability to integrate data from different domains in a sensible and machine-readable way. Thus, they can be used to model a variety of systems such as molecules…

Neural and Evolutionary Computing · Computer Science 2023-08-28 Dominik Dold , Josep Soler Garrido , Victor Caceres Chian , Marcel Hildebrandt , Thomas Runkler

Interpretability is significant in computational pathology, leading to the development of multimodal information integration from histopathological image and corresponding text data.However, existing multimodal methods have limited…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Kangcheng Zhou , Jun Jiang , Qing Zhang , Shuang Zheng , Qingli Li , Shugong Xu

The study of cellular signalling pathways and their deregulation in disease states, such as cancer, is a large and extremely complex task. Indeed, these systems involve many parts and processes but are studied piecewise and their…

Artificial Intelligence · Computer Science 2016-08-22 Adrien Basso-Blandin , Walter Fontana , Russ Harmer

Reasoning is a fundamental problem for computers and deeply studied in Artificial Intelligence. In this paper, we specifically focus on answering multi-hop logical queries on Knowledge Graphs (KGs). This is a complicated task because, in…

Artificial Intelligence · Computer Science 2022-09-30 Alfonso Amayuelas , Shuai Zhang , Susie Xi Rao , Ce Zhang

Biomedical entity linking (BEL) is the task of grounding entity mentions to a knowledge base. It plays a vital role in information extraction pipelines for the life sciences literature. We review recent work in the field and find that, as…

Computation and Language · Computer Science 2023-08-23 Samuele Garda , Leon Weber-Genzel , Robert Martin , Ulf Leser

Medical ontology graphs map external knowledge to medical codes in electronic health records via structured relationships. By leveraging domain-approved connections (e.g., parent-child), predictive models can generate richer medical concept…

Artificial Intelligence · Computer Science 2025-09-01 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Dongjie Wang , Zijun Yao

Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

Machine Learning · Computer Science 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

Progress in biomedical Named Entity Recognition (NER) and Entity Linking (EL) is currently hindered by a fragmented data landscape, a lack of resources for building explainable models, and the limitations of semantically-blind evaluation…

Computation and Language · Computer Science 2025-11-17 Nishant Mishra , Wilker Aziz , Iacer Calixto

Retrieving targeted pathways in biological knowledge bases, particularly when incorporating wet-lab experimental data, remains a challenging task and often requires downstream analyses and specialized expertise. In this paper, we frame this…

Machine Learning · Computer Science 2026-04-14 Rikuto Kotoge , Ziwei Yang , Zheng Chen , Yushun Dong , Yasuko Matsubara , Jimeng Sun , Yasushi Sakurai

Probabilistic logical rule learning has shown great strength in logical rule mining and knowledge graph completion. It learns logical rules to predict missing edges by reasoning on existing edges in the knowledge graph. However, previous…

Artificial Intelligence · Computer Science 2023-05-23 Chi Han , Qizheng He , Charles Yu , Xinya Du , Hanghang Tong , Heng Ji

In knowledge-intensive tasks, especially in high-stakes domains like medicine and law, it is critical not only to retrieve relevant information but also to provide causal reasoning and explainability. Large language models (LLMs) have…

Artificial Intelligence · Computer Science 2025-03-18 Hang Luo , Jian Zhang , Chujun Li

In this study, we introduced a new benchmark consisting of a curated dataset and a defined evaluation process to assess the compositional reasoning capabilities of large language models within the chemistry domain. We designed and validated…

Computation and Language · Computer Science 2025-08-07 Mohammad Khodadad , Ali Shiraee Kasmaee , Mahdi Astaraki , Nicholas Sherck , Hamidreza Mahyar , Soheila Samiee

Contextual information is widely considered for NLP and knowledge discovery in life sciences since it highly influences the exact meaning of natural language. The scientific challenge is not only to extract such context data, but also to…

Databases · Computer Science 2020-01-24 Jens Dörpinghaus , Andreas Stefan , Bruce Schultz , Marc Jacobs

Answering questions that require multi-hop reasoning at web-scale necessitates retrieving multiple evidence documents, one of which often has little lexical or semantic relationship to the question. This paper introduces a new graph-based…

Computation and Language · Computer Science 2020-02-17 Akari Asai , Kazuma Hashimoto , Hannaneh Hajishirzi , Richard Socher , Caiming Xiong