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Structural equation modeling (SEM) is a popular tool in the social and behavioural sciences, where it is being applied to ever more complex data types. The high-dimensional data produced by modern sensors, brain images, or (epi)genetic…

Methodology · Statistics 2019-10-11 Erik-Jan van Kesteren , Daniel L. Oberski

Ecologists and evolutionary biologists are relying on an increasingly sophisticated set of statistical tools to describe complex natural systems. One such tool that has gained increasing traction in the life sciences is structural equation…

Quantitative Methods · Quantitative Biology 2015-09-08 Jonathan S. Lefcheck

Structural equation models (SEMs) have been widely adopted for inference of causal interactions in complex networks. Recent examples include unveiling topologies of hidden causal networks over which processes such as spreading diseases, or…

Machine Learning · Statistics 2017-04-05 Yanning Shen , Brian Baingana , Georgios B. Giannakis

Graph-level regression underpins many real-world applications, yet public benchmarks remain heavily skewed toward molecular graphs and citation networks. This limited diversity hinders progress on models that must generalize across both…

Machine Learning · Computer Science 2026-05-04 Peter Samoaa , Marcus Vukojevic , Morteza Haghir Chehreghani , Antonio Longa

Causal inference is a crucial goal of science, enabling researchers to arrive at meaningful conclusions regarding the predictions of hypothetical interventions using observational data. Path models, Structural Equation Models (SEMs), and,…

Machine Learning · Statistics 2024-01-11 Matthew J. Vowels

Recent advances in computational methods for intractable models have made network data increasingly amenable to statistical analysis. Exponential random graph models (ERGMs) emerged as one of the main families of models capable of capturing…

Computation · Statistics 2021-04-07 Alberto Caimo , Lampros Bouranis , Robert Krause , Nial Friel

Motivation: Mendelian randomization (MR) infers causal relationships between exposures and outcomes using genetic variants as instrumental variables. Typically, MR considers only a pair of exposure and outcome at a time, limiting its…

Applications · Statistics 2025-10-14 Bitan Sarkar , Yang Ni

The past decade has seen an increasing body of literature devoted to the estimation of causal effects in network-dependent data. However, the validity of many classical statistical methods in such data is often questioned. There is an…

Computation · Statistics 2017-05-31 Oleg Sofrygin , Romain Neugebauer , Mark J. van der Laan

Groups with complex set intersection relations are a natural way to model a wide array of data, from the formation of social groups to the complex protein interactions which form the basis of biological life. One approach to representing…

Machine Learning · Computer Science 2025-01-15 Sepideh Maleki , Josh Vekhter , Keshav Pingali

Heterogeneous graph neural networks have become popular in various domains. However, their generalizability and interpretability are limited due to the discrepancy between their inherent inference flows and human reasoning logic or…

Machine Learning · Computer Science 2023-12-12 Tianqianjin Lin , Kaisong Song , Zhuoren Jiang , Yangyang Kang , Weikang Yuan , Xurui Li , Changlong Sun , Cui Huang , Xiaozhong Liu

Complex systems are often driven by higher-order interactions among multiple units, naturally represented as hypergraphs. Understanding dependency structures within these hypergraphs is crucial for understanding and predicting the behavior…

Social and Information Networks · Computer Science 2025-05-29 John Hood , Caterina De Bacco , Aaron Schein

Structural equation modelling (SEM) is a multivariate statistical technique for estimating complex relationships between observed and latent variables. Although numerous SEM packages exist, each of them has limitations. Some packages are…

Applications · Statistics 2021-06-02 Meshcheryakov Georgy , Igolkina Anna

The causalimages R package enables causal inference with image and image sequence data, providing new tools for integrating novel data sources like satellite and bio-medical imagery into the study of cause and effect. One set of functions…

Machine Learning · Computer Science 2023-11-13 Connor T. Jerzak , Adel Daoud

Graphical models are a powerful tool in modelling and analysing complex biological associations in high-dimensional data. The R-package netgwas implements the recent methodological development on copula graphical models to (i) construct…

Applications · Statistics 2023-01-27 Pariya Behrouzi , Danny Arends , Ernst C. Wit

Exponential-family random graph models (ERGMs) are probabilistic network models that are parametrized by sufficient statistics based on structural (i.e., graph-theoretic) properties. The ergm package for the R statistical computing system…

Social and Information Networks · Computer Science 2015-06-24 Omer Nebil Yaveroglu , Sean M. Fitzhugh , Maciej Kurant , Athina Markopoulou , Carter T. Butts , Natasa Przulj

Daily internet communication relies heavily on tree-structured graphs, embodied by popular data formats such as XML and JSON. However, many recent generative (probabilistic) models utilize neural networks to learn a probability distribution…

Machine Learning · Computer Science 2024-08-20 Milan Papež , Martin Rektoris , Tomáš Pevný , Václav Šmídl

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from…

Machine Learning · Computer Science 2026-03-30 Munib Mesinovic , Max Buhlan , Tingting Zhu

With many frameworks based on message passing neural networks proposed to predict molecular and bulk properties, machine learning methods have tremendously shifted the paradigms of computational sciences underpinning physics, material…

Machine Learning · Computer Science 2021-09-03 Zun Wang , Chong Wang , Sibo Zhao , Yong Xu , Shaogang Hao , Chang Yu Hsieh , Bing-Lin Gu , Wenhui Duan

Structural Equation Modeling (SEM) is an umbrella term that includes numerous multivariate statistical techniques that are employed throughout a plethora of research areas, ranging from social to natural sciences. Until recently, SEM…

Applications · Statistics 2021-06-10 Georgy Meshcheryakov , Anna A. Igolkina , Maria G. Samsonova

We propose a novel computational framework leveraging hypergraph theory to analyse cancer stem cell markers (CSCMs) across multiple organs. Hypergraphs provide a robust representation of CSCM co-expression patterns, capturing their complex…

Biological Physics · Physics 2025-08-01 David H. Margarit , Gustavo Paccosi , Marcela V. Reale , Lilia M. Romanelli
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