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Imaging flow cytometry systems aim to analyze a huge number of cells or micro-particles based on their physical characteristics. The vast majority of current systems acquire a large amount of images which are used to train deep artificial…

Neural and Evolutionary Computing · Computer Science 2023-03-21 Muhammed Gouda , Steven Abreu , Alessio Lugnan , Peter Bienstman

It has long been debated whether information in the brain is coded at the rate of neuronal spiking or at the precise timing of single spikes. Although this issue is essential to the understanding of neural signal processing, it is not…

Neurons and Cognition · Quantitative Biology 2014-02-17 Yasuhiro Mochizuk , Shigeru Shinomoto

A fundamental problem in neuroscience is to characterize the dynamics of spiking from the neurons in a circuit that is involved in learning about a stimulus or a contingency. A key limitation of current methods to analyze neural spiking…

Methodology · Statistics 2017-09-29 Yingzhuo Zhang , Noa Malem-Shinitski , Stephen A Allsop , Kay Tye , Demba Ba

Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and…

Subcellular Processes · Quantitative Biology 2013-05-01 S. L. Mironov

Spiking neural networks (SNNs) have gained attention as models of sparse and event-driven communication of biological neurons, and as such have shown increasing promise for energy-efficient applications in neuromorphic hardware. As with…

Neural and Evolutionary Computing · Computer Science 2023-12-08 Tao Sun , Bojian Yin , Sander Bohte

Despite coronary artery calcium scoring being considered a largely solved problem within the realm of medical artificial intelligence, this paper argues that significant improvements can still be made. By shifting the focus from pathology…

The design and analysis of spiking neural network algorithms will be accelerated by the advent of new theoretical approaches. In an attempt at such approach, we provide a principled derivation of a spiking algorithm for unsupervised…

Neural and Evolutionary Computing · Computer Science 2019-02-19 Cengiz Pehlevan

Stability arguments are often used to prevent learning algorithms from having ever increasing activity and weights that hinder generalization. However, stability conditions can clash with the sparsity required to augment the energy…

Neural and Evolutionary Computing · Computer Science 2024-01-08 Luca Herranz-Celotti , Jean Rouat

Online decision making aims to learn the optimal decision rule by making personalized decisions and updating the decision rule recursively. It has become easier than before with the help of big data, but new challenges also come along.…

Machine Learning · Statistics 2020-10-16 Haoyu Chen , Wenbin Lu , Rui Song

Investigating the spectral properties of the neural covariates that underlie spiking activity is an important problem in systems neuroscience, as it allows to study the role of brain rhythms in cognitive functions. While the spectral…

Signal Processing · Electrical Eng. & Systems 2019-06-21 Proloy Das , Behtash Babadi

The combination of spiking neural networks and event-based vision sensors holds the potential of highly efficient and high-bandwidth optical flow estimation. This paper presents the first hierarchical spiking architecture in which motion…

Computer Vision and Pattern Recognition · Computer Science 2019-03-29 Federico Paredes-Vallés , Kirk Y. W. Scheper , Guido C. H. E. de Croon

Humans and other animals behave as if we perform fast Bayesian inference underlying decisions and movement control given uncertain sense data. Here we show that a biophysically realistic model of the subthreshold membrane potential of a…

Neurons and Cognition · Quantitative Biology 2014-06-20 Michael G. Paulin , Andre van Schaik

The activity of an isolated and auto-connected neuron is studied using Hodgkin--Huxley and Integrate-and-Fire frameworks. Main ingredients of the modeling are the auto-stimulating autaptic current observed in experiments, with a spontaneous…

Neurons and Cognition · Quantitative Biology 2007-05-23 Simona Cocco

The computation performed by a neuron can be formulated as a combination of dimensional reduction in stimulus space and the nonlinearity inherent in a spiking output. White noise stimulus and reverse correlation (the spike-triggered average…

Biological Physics · Physics 2007-05-23 Blaise Aguera y Arcas , Adrienne Fairhall

Extracting the spectral representations of the neural processes that underlie spiking activity is key to understanding how the brain rhythms mediate cognitive functions. While spectral estimation of continuous time-series is well studied,…

Information Theory · Computer Science 2020-12-02 Anuththara Rupasinghe , Behtash Babadi

We propose a regression model for count data when the classical generalized linear model approach is too rigid due to a high outcome of zero counts and a nonlinear influence of continuous covariates. Zero-Inflation is applied to take into…

Methodology · Statistics 2013-04-12 T. Opitz , P. Tramini , N. Molinari

Neurons in cortical circuits exhibit coordinated spiking activity, and can produce correlated synchronous spikes during behavior and cognition. We recently developed a method for estimating the dynamics of correlated ensemble activity by…

Neurons and Cognition · Quantitative Biology 2013-12-17 Hideaki Shimazaki

Neural noise sets a limit to information transmission in sensory systems. In several areas, the spiking response (to a repeated stimulus) has shown a higher degree of regularity than predicted by a Poisson process. However, a simple model…

Neurons and Cognition · Quantitative Biology 2018-01-08 Ulisse Ferrari , Stephane Deny , Olivier Marre , Thierry Mora

We consider the problem of testing for a difference in means between clusters of observations identified via k-means clustering. In this setting, classical hypothesis tests lead to an inflated Type I error rate. To overcome this problem, we…

Methodology · Statistics 2022-03-30 Yiqun T. Chen , Daniela M. Witten

Solving constraint satisfaction problems (CSPs) is a notoriously expensive computational task. Recently, it has been proposed that efficient stochastic solvers can be obtained through appropriately configured spiking neural networks…

Neural and Evolutionary Computing · Computer Science 2016-04-07 Jonathan Binas , Giacomo Indiveri , Michael Pfeiffer