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A novel modelling technique using finite element analysis to mimic the mechanoresponse of cell-laden biomaterial is proposed for the use in bioinks and other tissue engineering applications. Here a hydrogel-based composite biomaterial…

Materials Science · Physics 2022-10-25 Abhinaba Banerjee , Sudipto Datta , Amit Roy Chowdhury , Pallab Datta

Computational stress analysis is an important step in the design of material systems. Finite element method (FEM) is a standard approach of performing stress analysis of complex material systems. A way to accelerate stress analysis is to…

Materials Science · Physics 2023-01-02 Anindya Bhaduri , Ashwini Gupta , Lori Graham-Brady

Wound geometry and the mechanical properties of human skin govern the failure modes of partially healed or scarred tissue. Though dermatologists and surgeons develop an intuitive understanding of the mechanical characteristics of skin…

Medical Physics · Physics 2025-07-30 Congzhou M Sha

This paper proposes a methodology to estimate stress in the subsurface by a hybrid method combining finite element modeling and neural networks. This methodology exploits the idea of obtaining a multi-frequency solution in the numerical…

Machine Learning · Computer Science 2020-08-27 Xavier Garcia , Adrian Rodriguez-Herrera

As inelastic structures are ubiquitous in many engineering fields, a central task in computational mechanics is to develop accurate, robust and efficient tools for their analysis. Motivated by the poor performances exhibited by standard…

Numerical Analysis · Mathematics 2018-09-21 Nicola A. Nodargi

Selective laser melting is receiving increasing interest as an additive manufacturing technique. Residual stresses induced by the large temperature gradients and inhomogeneous cooling process can favour the generation of cracks. In this…

Materials Science · Physics 2021-07-20 Nicolò Grilli , Daijun Hu , Dewen Yushu , Fan Chen , Wentao Yan

This article addresses the research question if and how the finite cell method, an embedded domain finite element method of high order, may be used in the simulation of metal deposition to harvest its computational efficiency. This…

Numerical Analysis · Mathematics 2018-09-26 Ali Özcan , Stefan Kollmannsberger , John N. Jomo , Ernst Rank

The capacity to predict and control bioprocesses is perhaps one of the most important objectives of biotechnology. Computational simulation is an established methodology for the design and optimization of bioprocesses, where the finite…

Computational Engineering, Finance, and Science · Computer Science 2015-08-12 R. C. Martins , N. Fachada

Tissue engineering aims to grow artificial tissues \emph{in vitro} to replace those in the body that have been damaged through age, trauma or disease. A recent approach to engineer artificial cartilage involves seeding cells within a…

Soft Condensed Matter · Physics 2017-12-05 M. J. Chen , L. S. Kimpton , J. P. Whiteley , M. Castilho , J. Malda , C. P. Please , S. L. Waters , H. M. Byrne

The mechanics of animal cells is strongly determined by stress fibers, which are contractile filament bundles that form dynamically in response to extracellular cues. Stress fibers allow the cell to adapt its mechanics to environmental…

Biological Physics · Physics 2024-10-15 Lukas Riedel , Valentin Wössner , Dominic Kempf , Falko Ziebert , Peter Bastian , Ulrich S. Schwarz

Extrusion-based 3D printing is a widely utilized tool in tissue engineering, offering precise 3D control of bioinks to construct organ-sized biomaterial objects with hierarchically organized cellularized scaffolds. The internal organization…

Tissues and Organs · Quantitative Biology 2024-12-31 V. T. Mai , R. Chatelin , E. -J. Courtial , C. Boulocher , R. Rieger

Shear stress is an important physical factor that regulates proliferation, migration and morphogenesis. In particular, the homeostasis of blood vessels is dependent on shear stress. To mimic this process ex vivo, efforts have been made to…

Soft Condensed Matter · Physics 2013-01-15 K. Youssef , J. J. Mack , M. L. Iruela-Arispe , L. -S. Bouchard

Cell blebs are protrusions of the cell membrane and can be instrumental for cell migration. We derive a continuum model for the mechanical and geometrical aspects of the onset of blebbing in terms of a force balance. It is abstract and…

Numerical Analysis · Mathematics 2020-03-03 Björn Stinner , Andreas Dedner , Adam Nixon

The mechanical problem discussed in this paper focuses on the stress state estimation in a composite laminate in the vicinity of a free edge or microcracks. To calculate these stresses, we use two models called Multiparticle Models of…

Classical Physics · Physics 2009-07-07 Rui Pedro Carreira , Jean-François Caron , Alberto Diaz Diaz

This work develops a polygonal finite element method (PFEM) for the analysis of steady-state and transient thermal stresses in two dimensional continua. The method employs Wachspress rational basis functions to construct conforming…

Numerical Analysis · Mathematics 2025-04-23 Yang Yang , Mingjiao Yan , Zongliang Zhang , Dengmiao Hao , Xuedong Chen , Weixiong Chen

Correlating articular cartilage material properties to quantitative magnetic resonance imaging biomarkers is a powerful approach to biofidelic finite element models. However, subject-specific relationships between imaging biomarkers such as…

Image and Video Processing · Electrical Eng. & Systems 2025-11-17 Alexander A. Donabedian , Deva D. Chan

Residual stress and plastic strain in additive manufactured materials can exhibit significant microscopic variation at the powder scale, profoundly influencing the overall properties of printed components. This variation depends on…

Materials Science · Physics 2024-06-19 Yangyiwei Yang , Somnath Bharech , Nick Finger , Xiandong Zhou , Joerg Schroeder , Bai-Xiang Xu

This work presents a multi-level modeling and design framework for weft knitted fabrics, beginning with a volumetric finite element analysis capturing their mechanical behavior from fundamental principles. Incorporating yarn-level data, it…

We propose an adaptive polygonal finite element formulation for collapse plastic analysis of solids. The article contributes into four crucial points: 1) Wachspress shape functions at vertex and bubble nodes handled at a primal-mesh level;…

Computational Engineering, Finance, and Science · Computer Science 2016-06-30 H. Nguyen-Xuan , Son H. Nguyen , Hyun-Gyu Kim , Klaus Hackl

We derive a mixture theory-based mathematical model of the degradation of a poroelastic solid immersed in a fluid bath. The evolution of the solid's mechanical and transport properties are also modeled. The inspiration for the model is the…

Biological Physics · Physics 2019-12-16 Priyanka Patki , Francesco Costanzo
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