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The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network's constituent motor…

Subcellular Processes · Quantitative Biology 2017-12-19 Peter J. Foster , Wen Yan , Sebastian Fürthauer , Michael J. Shelley , Daniel J. Needleman

In this paper, we introduce a three-dimensional mathematical model of collagen contraction with microbuckling based on the two-dimensional model previously developed by the authors. The model both qualitatively and quantitatively replicates…

Cell Behavior · Quantitative Biology 2018-01-03 Emily Jennings Evans , John C. Dallon

Animal morphogenesis often involves significant shape changes of epithelial tissue sheets. Great progress has been made in understanding the underlying cellular driving forces and their coordination through biomechanical feedback loops.…

Soft Condensed Matter · Physics 2024-09-23 Nikolas H. Claussen , Fridtjof Brauns

Elastomers that can sustain large reversible strain are essential components for stretchable electronics. The stretchability and mechanical robustness of unfilled elastomers can be enhanced by introducing easier-to-break cross-links, e.g.…

Soft Condensed Matter · Physics 2020-01-20 Yikai Yin , Nicolas Bertin , Yanming Wang , Zhenan Bao , Wei Cai

Cortical bone is a tough biological material composed of tube-like osteons embedded in the organic matrix surrounded by weak interfaces known as cement lines. The cement lines provide a microstructurally preferable crack path, hence…

Applied Physics · Physics 2024-05-24 Shashank Gupta , Reza Moini

Networks with only central force interactions are floppy when their average connectivity is below an isostatic threshold. Although such networks are mechanically unstable, they can become rigid when strained. It was recently shown that the…

Biological Physics · Physics 2016-10-19 A. Sharma , A. J. Licup , R. Rens , M. Vahabi , K. A. Jansen , G. H. Koenderink , F. C. MacKintosh

As a model of composite material, the fiber bundle model has been chosen -where a bundle of fibers is subjected to external load and fibers have distributed thresholds. For different loading conditions, such a system shows few precursors…

Materials Science · Physics 2015-05-19 Srutarshi Pradhan

Soft tissues - such as ligaments and tendons - primarily consist of solid (collagen, predominantly) and liquid phases. Understanding the interaction between such components and how they change under physiological loading sets the basis for…

The performance of bio-inspired fibrillar adhesives can be compromised by surface roughness, manufacturing imperfections or impurities. Previous studies investigated the cases of distributed defects on the array, and defects at the level of…

Soft Condensed Matter · Physics 2026-03-27 Agostinelli Daniele , Shojaeifard Mohammad , Bacca Mattia

We propose a constitutive model to predict the viscosity of fiber suspensions, which undergoes shear thinning, at various volume fractions, aspect ratios, and shear stresses/rates. We calibrate the model using the data from direct numerical…

Fluid Dynamics · Physics 2023-02-08 Monsurul Khan , Rishabh V. More , Arezoo M. Ardekani

We investigate interface failure of model materials representing architected thin films in contact with heterogeneous substrates. We find that, while systems with statistically isotropic distributions of impurities derive their fracture…

Materials Science · Physics 2024-05-30 Christian Greff , Paolo Moretti , Michael Zaiser

Two approaches to incorporate heterogeneity in discrete models are compared. In the first, standard approach, the heterogeneity is dictated by geometrical structure of the discrete system. In the second approach, the heterogeneity is…

Computational Engineering, Finance, and Science · Computer Science 2025-06-26 Jan Raisinger , Qiwei Zhang , John E. Bolander , Jan Eliáš

The fiber bundle model describes a collection of elastic fibers under load. the fibers fail successively and for each failure, the load distribution among the surviving fibers change. Even though very simple, the model captures the…

Statistical Mechanics · Physics 2015-05-13 Srutarshi Pradhan , Alex Hansen , Bikas K. Chakrabarti

This paper presents a micromechanical study of unsaturated granular media in the pendular regime, based upon numerical experiments using the discrete element method, compared to a microstructural elastoplastic model. Water effects are taken…

Soft Condensed Matter · Physics 2011-05-06 Luc Scholtès , Pierre-Yves Hicher , François Nicot , Bruno Chareyre , Félix Darve

Collagen is the key protein of connective tissue (i.e., skin, tendons and ligaments, cartilage, among others) accounting for 25% to 35% of the whole-body protein content, and entitled of conferring mechanical stability. This protein is also…

Applied Physics · Physics 2021-01-27 Mario Milazzo , Gang Seob Jung , Serena Danti , Markus J. Buehler

Disorder and long-range interactions are two of the key components that make material failure an interesting playfield for the application of statistical mechanics. The cornerstone in this respect has been lattice models of the fracture in…

Statistical Mechanics · Physics 2009-11-11 Mikko J. Alava , Phani K. V. V. Nukala , Stefano Zapperi

We study the fatigue fracture of disordered materials by means of computer simulations of a discrete element model. We extend a two-dimensional fracture model to capture the microscopic mechanisms relevant for fatigue, and we simulate the…

Disordered Systems and Neural Networks · Physics 2009-11-11 H. A. Carmona , F. Kun , J. S. Andrade , H. J. Herrmann

Stress-strain relations for random packings of entangling chains under triaxial compression can exhibit strain stiffening and sustain stresses several orders-of-magnitude beyond typical granular materials. X-ray tomography reveals the…

Soft Condensed Matter · Physics 2025-02-12 Eric Brown , Kevin A. Mitchell , Alice Nasto , Athanasios Athanassiadis , Heinrich M. Jaeger

Crack initiation governs high cycle fatigue life and is susceptible to microstructural details. While corresponding microstructure-sensitive models are available, their validation is difficult. We propose a validation framework where a…

The effect of self-generated tension in the backbone of a bottle-brush (BB) macromolecule, adsorbed on an attractive surface, is studied by means of Molecular Dynamics simulations of a coarse-grained bead-spring model in the good solvent…

Soft Condensed Matter · Physics 2015-06-03 J. Paturej , L. Kuban , A. Milchev , T. A. Vilgis