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Backpropagation is the foundational algorithm for training neural networks and a key driver of deep learning's success. However, its biological plausibility has been challenged due to three primary limitations: weight symmetry, reliance on…

Neural and Evolutionary Computing · Computer Science 2025-06-05 Changze Lv , Jingwen Xu , Yiyang Lu , Xiaohua Wang , Zhenghua Wang , Zhibo Xu , Di Yu , Xin Du , Xiaoqing Zheng , Xuanjing Huang

Deep neural networks excel at image classification, but their performance is far less robust to input perturbations than human perception. In this work we explore whether this shortcoming may be partly addressed by incorporating…

Computer Vision and Pattern Recognition · Computer Science 2021-11-05 Bhavin Choksi , Milad Mozafari , Callum Biggs O'May , Benjamin Ador , Andrea Alamia , Rufin VanRullen

Neuroscience and Artificial Intelligence (AI) have progressed in tandem, each contributing to our understanding of the brain, and inspiring recent developments in biologically-plausible neural networks (NNs) and learning rules. Predictive…

Neural and Evolutionary Computing · Computer Science 2024-06-24 Ehsan Ganjidoost , Mallory Snow , Jeff Orchard

As deep neural networks are increasingly deployed in dynamic, real-world environments, relying on a single static model is often insufficient. Changes in input data distributions caused by sensor drift or lighting variations necessitate…

Machine Learning · Computer Science 2025-09-26 Matteo Cardoni , Sam Leroux

Back-propagation is a popular machine learning algorithm that uses gradient descent in training neural networks for supervised learning, but can be very slow. A number of algorithms have been developed to speed up convergence and improve…

Neural and Evolutionary Computing · Computer Science 2020-09-29 Ho Ling Li

The last decade has seen the parallel emergence in computational neuroscience and machine learning of neural network structures which spread the input signal randomly to a higher dimensional space; perform a nonlinear activation; and then…

Neural and Evolutionary Computing · Computer Science 2013-06-11 Jonathan Tapson , Andre van Schaik

Inspired by "predictive coding" - a theory in neuroscience, we develop a bi-directional and dynamic neural network with local recurrent processing, namely predictive coding network (PCN). Unlike feedforward-only convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2018-10-29 Kuan Han , Haiguang Wen , Yizhen Zhang , Di Fu , Eugenio Culurciello , Zhongming Liu

Despite being the cornerstone of deep learning, backpropagation is criticized for its inherent sequentiality, which can limit the scalability of very deep models. Such models faced convergence issues due to vanishing gradient, later…

Machine Learning · Computer Science 2025-04-01 Erwan Fagnou , Paul Caillon , Blaise Delattre , Alexandre Allauzen

Training networks consisting of biophysically accurate neuron models could allow for new insights into how brain circuits can organize and solve tasks. We begin by analyzing the extent to which the central algorithm for neural network…

Neurons and Cognition · Quantitative Biology 2023-11-22 James Hazelden , Yuhan Helena Liu , Eli Shlizerman , Eric Shea-Brown

Training deep neural networks on large-scale datasets requires significant hardware resources whose costs (even on cloud platforms) put them out of reach of smaller organizations, groups, and individuals. Backpropagation, the workhorse for…

Machine Learning · Computer Science 2020-09-22 Alexander Ororbia , Ankur Mali , Daniel Kifer , C. Lee Giles

Many of the recent advances in the field of artificial intelligence have been fueled by the highly successful backpropagation of error (BP) algorithm, which efficiently solves the credit assignment problem in artificial neural networks.…

Machine Learning · Computer Science 2023-01-25 Sander Dalm , Nasir Ahmad , Luca Ambrogioni , Marcel van Gerven

Machine learning algorithms, and more in particular neural networks, arguably experience a revolution in terms of performance. Currently, the best systems we have for speech recognition, computer vision and similar problems are based on…

Neural and Evolutionary Computing · Computer Science 2015-10-07 Michiel Hermans , Michaël Burm , Joni Dambre , Peter Bienstman

Deep learning is computationally intensive, with significant efforts focused on reducing arithmetic complexity, particularly regarding energy consumption dominated by data movement. While existing literature emphasizes inference, training…

Machine Learning · Statistics 2025-06-09 Van Minh Nguyen , Cristian Ocampo , Aymen Askri , Louis Leconte , Ba-Hien Tran

Brains remain unrivaled in their ability to recognize and generate complex spatiotemporal patterns. While AI is able to reproduce some of these capabilities, deep learning algorithms remain largely at odds with our current understanding of…

Neurons and Cognition · Quantitative Biology 2026-03-13 Simon Brandt , Paul Haider , Walter Senn , Federico Benitez , Mihai A. Petrovici

Deep learning continues to play as a powerful state-of-art technique that has achieved extraordinary accuracy levels in various domains of regression and classification tasks, including images, video, signal, and natural language data. The…

Neural and Evolutionary Computing · Computer Science 2022-06-03 Anna Zou , Zhiyuan Li

Neuroscientists have long criticised deep learning algorithms as incompatible with current knowledge of neurobiology. We explore more biologically plausible versions of deep representation learning, focusing here mostly on unsupervised…

Machine Learning · Computer Science 2016-08-10 Yoshua Bengio , Dong-Hyun Lee , Jorg Bornschein , Thomas Mesnard , Zhouhan Lin

Backpropagation is the default algorithm for training deep neural networks due to its simplicity, efficiency and high convergence rate. However, its requirements make it impossible to be implemented in a human brain. In recent years, more…

Machine Learning · Computer Science 2021-09-01 Albert Jiménez Sanfiz , Mohamed Akrout

Backpropagation, a foundational algorithm for training artificial neural networks, predominates in contemporary deep learning. Although highly successful, it is widely considered biologically implausible, because it relies on precise…

Machine Learning · Computer Science 2025-10-07 Li Ji-An , Marcus K. Benna

Deep-predictive-coding networks (DPCNs) are hierarchical, generative models. They rely on feed-forward and feed-back connections to modulate latent feature representations of stimuli in a dynamic and context-sensitive manner. A crucial…

Artificial Intelligence · Computer Science 2021-09-27 Isaac J. Sledge , Jose C. Principe

Darwinian evolution of the biological brain is documented through multiple lines of evidence, although the modes of evolutionary changes remain unclear. Drawing inspiration from the evolved neural systems (e.g., visual cortex), deep…

Neural and Evolutionary Computing · Computer Science 2024-08-13 Guodong Du , Runhua Jiang , Senqiao Yang , Haoyang Li , Wei Chen , Keren Li , Sim Kuan Goh , Ho-Kin Tang
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