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Coronavirus Disease 2019 (COVID-19) has been creating a worldwide pandemic situation. Repurposing drugs, already shown to be free of harmful side effects, for the treatment of COVID-19 patients is an important option in launching novel…

Molecular Networks · Quantitative Biology 2020-07-07 Sumanta Ray , Snehalika Lall , Anirban Mukhopadhyay , Sanghamitra Bandyopadhyay , Alexander Schönhuth

Discovering disease pathways, which can be defined as sets of proteins associated with a given disease, is an important problem that has the potential to provide clinically actionable insights for disease diagnosis, prognosis, and…

Molecular Networks · Quantitative Biology 2017-12-05 Monica Agrawal , Marinka Zitnik , Jure Leskovec

The Brain-Heart Interconnectome (BHI) combines neurology and cardiology but is hindered by inefficiencies in evidence synthesis, poor adherence to quality standards, and research waste. To address these challenges, we developed an AI-driven…

We consider a joint information extraction (IE) model, solving named entity recognition, coreference resolution and relation extraction jointly over the whole document. In particular, we study how to inject information from a knowledge base…

Computation and Language · Computer Science 2021-07-07 Severine Verlinden , Klim Zaporojets , Johannes Deleu , Thomas Demeester , Chris Develder

Reconstruction of a high-dimensional network may benefit substantially from the inclusion of prior knowledge on the network topology. In the case of gene interaction networks such knowledge may come for instance from pathway repositories…

Mutual information (MI) is a general measure of statistical dependence with widespread application across the sciences. However, estimating MI between multi-dimensional variables is challenging because the number of samples necessary to…

Quantitative Methods · Quantitative Biology 2025-03-06 Gokul Gowri , Xiao-Kang Lun , Allon M. Klein , Peng Yin

Knowledge graph embeddings (KGEs) compactly encode multi-relational knowledge graphs (KGs). Existing KGE models rely on geometric operations to model relational patterns. Euclidean (circular) rotation is useful for modeling patterns such as…

Computation and Language · Computer Science 2021-09-30 Jia Guo , Stanley Kok

Gene expression datasets offer insights into gene regulation mechanisms, biochemical pathways, and cellular functions. Additionally, comparing gene expression profiles between disease and control patients can deepen the understanding of…

Machine Learning · Computer Science 2025-03-27 Rita T. Sousa , Heiko Paulheim

Beyond word embeddings, continuous representations of knowledge graph (KG) components, such as entities, types and relations, are widely used for entity mention disambiguation, relation inference and deep question answering. Great strides…

Information Retrieval · Computer Science 2018-05-15 Sandeep Subramanian , Soumen Chakrabarti

Pre-trained language models (PLMs) were considered to be able to store relational knowledge present in the training data. However, some relational knowledge seems to be discarded unsafely in PLMs due to \textbf{report bias}: low-frequency…

Computation and Language · Computer Science 2023-05-25 Hongbo Zhang , Xiang Wan , Benyou Wang

Embedding is a common technique for analyzing multi-dimensional data. However, the embedding projection cannot always form significant and interpretable visual structures that foreshadow underlying data patterns. We propose an approach that…

Human-Computer Interaction · Computer Science 2022-09-26 Jie Li , Chun-qi Zhou

In recent years, deep learning-based feature representation methods have shown a promising impact in electroencephalography (EEG)-based brain-computer interface (BCI). Nonetheless, owing to high intra- and inter-subject variabilities, many…

Machine Learning · Computer Science 2020-08-24 Eunjin Jeon , Wonjun Ko , Jee Seok Yoon , Heung-Il Suk

Recent urbanization has coincided with the enrichment of geotagged data, such as street view and point-of-interest (POI). Region embedding enhanced by the richer data modalities has enabled researchers and city administrators to understand…

Machine Learning · Computer Science 2021-05-07 Tianyuan Huang , Zhecheng Wang , Hao Sheng , Andrew Y. Ng , Ram Rajagopal

Recent years have witnessed the successful application of low-dimensional vector space representations of knowledge graphs to predict missing facts or find erroneous ones. However, it is not yet well-understood to what extent ontological…

Artificial Intelligence · Computer Science 2018-08-22 Víctor Gutiérrez-Basulto , Steven Schockaert

Background: Representing biological networks as graphs is a powerful approach to reveal underlying patterns, signatures, and critical components from high-throughput biomolecular data. However, graphs do not natively capture the multi-way…

Popular online enrichment analysis tools from the field of molecular systems biology provide users with the ability to submit their experimental results as gene sets for individual analysis. Such queries are kept private, and have never…

Molecular Networks · Quantitative Biology 2016-01-08 Avi Ma'ayan , Neil R. Clark

Research organisms provide invaluable insights into human biology and diseases, serving as essential tools for functional experiments, disease modeling, and drug testing. However, evolutionary divergence between humans and research…

Genomics · Quantitative Biology 2025-11-05 Hao Yuan , Christopher A. Mancuso , Kayla Johnson , Ingo Braasch , Arjun Krishnan

In Human-Robot Interaction (HRI) systems, a challenging task is sharing the representation of the operational environment, fusing symbolic knowledge and perceptions, between users and robots. With the existing HRI pipelines, users can teach…

Robotics · Computer Science 2023-01-18 E. Bartoli , F. Argenziano , V. Suriani , D. Nardi

Living systems are often described utilizing informational analogies. An important open question is whether information is merely a useful conceptual metaphor, or intrinsic to the operation of biological systems. To address this question,…

Molecular Networks · Quantitative Biology 2015-08-19 Hyunju Kim , Paul Davies , Sara Imari Walker

Recent works on representation learning for Knowledge Graphs have moved beyond the problem of link prediction, to answering queries of an arbitrary structure. Existing methods are based on ad-hoc mechanisms that require training with a…

Artificial Intelligence · Computer Science 2020-06-25 Daniel Daza , Michael Cochez
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