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We propose a novel testing and containment strategy in order to contain the spread of SARS-CoV2 while permitting large parts of the population to resume social and economic activity. Our approach recognises the fact that testing capacities…

Populations and Evolution · Quantitative Biology 2020-04-29 Jakob Jonnerby , Philip Lazos , Edwin Lock , Francisco Marmolejo-Cossío , C. Bronk Ramsey , Meghana Shukla , Divya Sridhar

A key requirement in containing contagious diseases, such as the Coronavirus disease 2019 (COVID-19) pandemic, is the ability to efficiently carry out mass diagnosis over large populations. Some of the leading testing procedures, such as…

Quantitative Methods · Quantitative Biology 2022-08-31 Amit Solomon , Alejandro Cohen , Nir Shlezinger , Yonina C. Eldar , Muriel Médard

Given the urgent informational needs connected with the diffusion of infection with regard to the COVID-19 pandemic, in this paper, we propose a sampling design for building a continuous-time surveillance system. Compared with other…

COVID-19 has resulted in a global health crisis that may become even more acute over the upcoming months. One of the main reasons behind the current rapid growth of COVID-19 in the U.S. population is the limited availability of testing kits…

Information Theory · Computer Science 2020-04-13 Krishna R. Narayanan , Anoosheh Heidarzadeh , Ramanan Laxminarayan

We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…

Information Theory · Computer Science 2020-07-07 Anoosheh Heidarzadeh , Krishna R. Narayanan

The corona virus disease 2019 (COVID-19) caused by the novel corona virus has an exponential rate of infection. COVID-19 is particularly notorious as the onset of symptoms in infected patients are usually delayed and there exists a large…

Methodology · Statistics 2020-04-16 Lakshmi N. Theagarajan

The cataclysmic contagion based calamity -- Covid-19 has shown us a clear need for a comprehensive community based strategy that overcomes the sheer complexity of controlling it and the caveats of current methods. In this regard, as seen in…

Physics and Society · Physics 2021-09-17 Surya Dheeshjith , Inavamsi Enaganti , Bud Mishra

We propose `Tapestry', a novel approach to pooled testing with application to COVID-19 testing with quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) that can result in shorter testing time and conservation of reagents…

In 2019, the world faced a new challenge: a COVID-19 disease caused by the novel coronavirus, SARS-CoV-2. The virus rapidly spread across the globe, leading to a high rate of mortality, which prompted health organizations to take measures…

Image and Video Processing · Electrical Eng. & Systems 2024-08-08 Kavian Khanjani , Seyed Rasoul Hosseini , Hamid Taheri , Shahrzad Shashaani , Mohammad Teshnehlab

We consider a novel method to increase the reliability of COVID-19 virus or antibody tests by using specially designed pooled testings. Instead of testing nasal swab or blood samples from individual persons, we propose to test mixtures of…

Quantitative Methods · Quantitative Biology 2020-07-30 Jirong Yi , Myung Cho , Xiaodong Wu , Weiyu Xu , Raghu Mudumbai

The usual problem for group testing is this: For a given number of individuals and a given prevalence, how many tests T* are required to find every infected individual? In real life, however, the problem is usually different: For a given…

Applications · Statistics 2021-07-21 Matthew Aldridge

In this paper, we consider the problem of designing optimal pooling matrix for group testing (for example, for COVID-19 virus testing) with the constraint that no more than $r>0$ samples can be pooled together, which we call "dilution…

Quantitative Methods · Quantitative Biology 2020-08-06 Jirong Yi , Myung Cho , Xiaodong Wu , Raghu Mudumbai , Weiyu Xu

Suppressing SARS-CoV-2 will likely require the rapid identification and isolation of infected individuals, on an ongoing basis. RT-PCR (reverse transcription polymerase chain reaction) tests are accurate but costly, making regular testing…

Very recently the new pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified and the coronavirus disease 2019 (COVID-19) declared a pandemic by the World Health Organization. The pandemic has a number of…

Coronavirus Disease 2019 (COVID-19) has spread globally and become a health crisis faced by humanity since first reported. Radiology imaging technologies such as computer tomography (CT) and chest X-ray imaging (CXR) are effective tools for…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Hongyan Xu , Dadong Wang , Arcot Sowmya

The world has witnessed unprecedented human and economic loss from the COVID-19 disease, caused by the novel coronavirus SARS-CoV-2. Extensive research is being conducted across the globe to identify therapeutic agents against the…

Biomolecules · Quantitative Biology 2020-04-09 Rohit Batra , Henry Chan , Ganesh Kamath , Rampi Ramprasad , Mathew J. Cherukara , Subramanian Sankaranarayanan

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a worldwide devastating effect. The understanding of evolution and transmission of SARS-CoV-2 is of paramount importance for the…

Quantitative Methods · Quantitative Biology 2021-01-01 Yuta Hozumi , Rui Wang , Changchuan Yin , Guo-Wei Wei

The coronavirus disease (COVID-19) is rapidly spreading all over the world, and has infected more than 1,436,000 people in more than 200 countries and territories as of April 9, 2020. Detecting COVID-19 at early stage is essential to…

Computer Vision and Pattern Recognition · Computer Science 2020-05-21 Xi Ouyang , Jiayu Huo , Liming Xia , Fei Shan , Jun Liu , Zhanhao Mo , Fuhua Yan , Zhongxiang Ding , Qi Yang , Bin Song , Feng Shi , Huan Yuan , Ying Wei , Xiaohuan Cao , Yaozong Gao , Dijia Wu , Qian Wang , Dinggang Shen

Long-term care facilities have been widely affected by the COVID-19 pandemic. Retirement homes are particularly vulnerable due to the higher mortality risk of infected elderly individuals. Once an outbreak occurs, suppressing the spread of…

Optimization and Control · Mathematics 2022-04-06 Mansoor Davoodi , Ana Batista , Abhishek Senapati , Weronika Schlechte-Welnicz , Birgit Wagner , Justin M. Calabrese

Fast testing can help mitigate the coronavirus disease 2019 (COVID-19) pandemic. Despite their accuracy for single sample analysis, infectious diseases diagnostic tools, like RT-PCR, require substantial resources to test large populations.…

Quantitative Methods · Quantitative Biology 2020-04-08 Junan Zhu , Kristina Rivera , Dror Baron