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The architecture of the human connectome supports efficient communication protocols relying either on distances between brain regions or on the intensities of connections. However, none of these protocols combines information about the two…

Neurons and Cognition · Quantitative Biology 2024-10-07 Laia Barjuan , Jordi Soriano , M. Ángeles Serrano

Human braingraphs or connectomes are widely studied in the last decade to understand the structural and functional properties of our brain. In the last several years our research group has computed and deposited thousands of human…

Neurons and Cognition · Quantitative Biology 2024-12-03 Balint Varga , Vince Grolmusz

In the high-dimensional landscape, addressing the challenges of covariance regression with high-dimensional covariates has posed difficulties for conventional methodologies. This paper addresses these hurdles by presenting a novel approach…

Methodology · Statistics 2024-04-11 Yuheng He , Changliang Zou , Yi Zhao

We take an image science perspective on the problem of determining brain network connectivity given functional activity. But adapting the concept of image resolution to this problem, we provide a new perspective on network partitioning for…

Neurons and Cognition · Quantitative Biology 2020-02-14 Keith Dillon , Yu-Ping Wang

The human connectome represents a network map of the brain's wiring diagram and the pattern into which its connections are organized is thought to play an important role in cognitive function. The generative rules that shape the topology of…

Neural models have shown promise in solving NP-hard graph combinatorial optimization (CO) problems. Once trained, they offer fast inference and reasonably high-quality solutions for in-distribution testing instances, but they generally fall…

Machine Learning · Computer Science 2025-11-26 Jialiang Li , Weitong Chen , Mingyu Guo

The human braingraph, or connectome is a description of the connections of the brain: the nodes of the graph correspond to small areas of the gray matter, and two nodes are connected by an edge if a diffusion MRI-based workflow finds fibers…

Neurons and Cognition · Quantitative Biology 2015-07-02 Csaba Kerepesi , Balázs Szalkai , Bálint Varga , Vince Grolmusz

The brain's intricate connectome, a blueprint for its function, presents immense complexity, yet it arises from a compact genetic code, hinting at underlying low-dimensional organizational principles. This work bridges connectomics and…

Artificial Intelligence · Computer Science 2025-05-28 Yubin Li , Xingyu Liu , Guozhang Chen

Network science has been extensively developed to characterize structural properties of complex systems, including brain networks inferred from neuroimaging data. As a result of the inference process, networks estimated from experimentally…

Neurons and Cognition · Quantitative Biology 2017-03-10 Catalina Obando , Fabrizio De Vico Fallani

Principal Subspace Analysis (PSA) -- and its sibling, Principal Component Analysis (PCA) -- is one of the most popular approaches for dimensionality reduction in signal processing and machine learning. But centralized PSA/PCA solutions are…

Machine Learning · Computer Science 2021-11-25 Arpita Gang , Bingqing Xiang , Waheed U. Bajwa

In this paper, we develop an approach to modeling high-dimensional networks with a large number of nodes arranged in a hierarchical and modular structure. We propose a novel multi-scale factor analysis (MSFA) model which partitions the…

Applications · Statistics 2020-04-10 Chee-Ming Ting , Hernando Ombao , Sh-Hussain Salleh

Deep, classical graph-theoretical parameters, like the size of the minimum vertex cover, the chromatic number, or the eigengap of the adjacency matrix of the graph were studied widely by mathematicians in the last century. Most researchers…

Neurons and Cognition · Quantitative Biology 2017-09-18 Balazs Szalkai , Balint Varga , Vince Grolmusz

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

Neurons and Cognition · Quantitative Biology 2023-08-24 Yihan Wu , Lana Vasung , Camilo Calixto , Ali Gholipour , Davood Karimi

This article focuses on the problem of predicting a response variable based on a network-valued predictor. Our motivation is the development of interpretable and accurate predictive models for cognitive traits and neuro-psychiatric…

Methodology · Statistics 2022-02-14 Subharup Guha , Rex Jung , David Dunson

This paper presents a Bayesian reformulation of covariate-assisted principal (CAP) regression of Zhao and others (2021), which aims to identify components in the covariance of response signal that are associated with covariates in a…

Methodology · Statistics 2024-08-30 Hyung G. Park

Accurately predicting individual neurons' responses and spatial functional properties in complex visual tasks remains a key challenge in understanding neural computation. Existing whole-brain connectome models of Drosophila often rely on…

Neurons and Cognition · Quantitative Biology 2025-12-09 Jiangping Xie , Ruohan Ren , Xiao Zhou , Ao Zheng , Jiasong Zhu , Wenyu Jiang , Ziran Zhao

One of the central problems in neuroscience is understanding how brain structure relates to function. Naively one can relate the direct connections of white matter fiber tracts between brain regions of interest (ROIs) to the increased…

Neurons and Cognition · Quantitative Biology 2023-08-30 Haoming Yang , Steven Winter , Zhengwu Zhang , David Dunson

Mapping the connectivity of neurons in the brain (i.e., connectomics) is a challenging problem due to both the number of connections in even the smallest organisms and the nanometer resolution required to resolve them. Because of this,…

Neurons and Cognition · Quantitative Biology 2014-09-08 Ting Zhao , Stephen M Plaza

The detailed functioning of the human brain is still poorly understood. Brain simulations are a well-established way to complement experimental research, but must contend with the computational demands of the approximately $10^{11}$ neurons…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-01 Fabian Czappa , Marvin Kaster , Felix Wolf

While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Jakob Wasserthal , Peter F. Neher , Klaus H. Maier-Hein
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