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Survival prediction with small sets of features is a highly relevant topic for decision-making in clinical practice. I describe a method for predicting survival of amyotrophic lateral sclerosis (ALS) patients that was developed as a…

Applications · Statistics 2016-12-05 Christoph Kurz

Numerous tutorials and research papers focus on methods in either survival analysis or causal inference, leaving common complications in medical studies unaddressed. In practice one must handle problems jointly, without the luxury of…

Applications · Statistics 2020-11-25 Camila Olarte Parra , Ingeborg Waernbaum , Staffan Schön , Els Goetghebeur

Patients with end-stage kidney disease can expect to wait for several years before they receive a transplant, all the while their health deteriorates. How would the survival change if we managed to reduce these waiting times? To provide an…

Methodology · Statistics 2022-07-19 Haris Fawad , Pål Ryalen , Vasiliki Tsarpali , Kristian Heldal , Kjetil Røysland

While kidney transplants are seen as the best treatment option for patients with end-stage renal disease and kidney failure, the organ's health depends on the dosage of immunosuppressant drugs post-transplantation. Due to the dosage…

Quantitative Methods · Quantitative Biology 2023-09-19 Kapil Panda , Anirudh Mazumder

A kidney exchange program, also called a kidney paired donation program, can be viewed as a repeated, dynamic trading and allocation mechanism. This suggests that a dynamic algorithm for transplant exchange selection may have superior…

Optimization and Control · Mathematics 2023-09-26 Margarida Carvalho , Alison Caulfield , Yi Lin , Adrian Vetta

Kidneys are the filter of the human body. About 10% of the global population is thought to be affected by Chronic Kidney Disease (CKD), which causes kidney function to decline. To protect in danger patients from additional kidney damage,…

Chronic kidney disease (CKD) represents a slowly progressive disorder that can eventually require renal replacement therapy (RRT) including dialysis or renal transplantation. Early identification of patients who will require RRT (as much as…

Machine Learning · Computer Science 2022-09-07 Daniel Lopez-Martinez , Christina Chen , Ming-Jun Chen

In clinical data sets we often find static information (e.g. patient gender, blood type, etc.) combined with sequences of data that are recorded during multiple hospital visits (e.g. medications prescribed, tests performed, etc.). Recurrent…

Machine Learning · Computer Science 2016-11-18 Cristóbal Esteban , Oliver Staeck , Yinchong Yang , Volker Tresp

Kidney cancer is a global health concern, and accurate assessment of patient frailty is crucial for optimizing surgical outcomes. This paper introduces AI Age Discrepancy, a novel metric derived from machine learning analysis of…

The time-varying effects model is a flexible and powerful tool for modeling the dynamic changes of covariate effects. However, in survival analysis, its computational burden increases quickly as the number of sample sizes or predictors…

Computation · Statistics 2020-01-01 Kevin He , Ji Zhu , Jian Kang , Yi Li

Bone Marrow Transplant, a gradational rescue for a wide range of disorders emanating from the bone marrow, is an efficacious surgical treatment. Several risk factors, such as post-transplant illnesses, new malignancies, and even organ…

Relatives and friends of an end-stage renal disease patient who offer to donate a kidney are often found to be incompatible with their intended recipients. Kidney paired donation matches one patient and his incompatible donor with another…

Computer Science and Game Theory · Computer Science 2017-10-24 Sommer Gentry , Michal Mankowski , T. S. Michael , Dorry Segev

The Kidney Exchange Problem is a prominent challenge in healthcare and economics, arising in the context of organ transplantation. It has been extensively studied in artificial intelligence and optimization. In a kidney exchange, a set of…

Data Structures and Algorithms · Computer Science 2026-05-12 Kangyi Tian , Mingyu Xiao

A survival analysis model for predicting time-to-total knee replacement (TKR) was developed using features from medical images and clinical measurements. Supervised and self-supervised deep learning approaches were utilized to extract…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Ozkan Cigdem , Shengjia Chen , Chaojie Zhang , Kyunghyun Cho , Richard Kijowski , Cem M. Deniz

Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the…

Machine Learning · Computer Science 2022-05-18 Andrea M. Storås , Anders Åsberg , Pål Halvorsen , Michael A. Riegler , Inga Strümke

Chronic kidney disease (CKD) is a significant public health challenge, often progressing to end-stage renal disease (ESRD) if not detected and managed early. Early intervention, warranted by silent disease progression, can significantly…

Machine Learning · Computer Science 2024-11-19 Zachary Dana , Ahmed Ammar Naseer , Botros Toro , Sumanth Swaminathan

Gliomas are lethal type of central nervous system tumors with a poor prognosis. Recently, with the advancements in the micro-array technologies thousands of gene expression related data of glioma patients are acquired, leading for salient…

Genomics · Quantitative Biology 2020-11-03 Navodini Wijethilake , Dulani Meedeniya , Charith Chitraranjan , Indika Perera

This work bridges the gap between staggered adoption designs and survival analysis to estimate causal effects in settings with time-varying treatments, addressing a fundamental challenge in medical research exemplified by the Stanford Heart…

Methodology · Statistics 2025-03-04 Xiang Meng , Iavor Bojinov

25% of people who received a liver transplant will go on to develop diabetes within the next 5 years. These thousands of individuals are at 2-fold higher risk of cardiovascular events, graft loss, infections, as well as lower long-term…

Machine Learning · Computer Science 2019-06-06 Angeline Yasodhara , Mamatha Bhat , Anna Goldenberg

Graft-versus-host disease (GVHD) is a rare but often fatal complication in liver transplantation, with a very high mortality rate. By harnessing multi-modal deep learning methods to integrate heterogeneous and imbalanced electronic health…

Machine Learning · Computer Science 2025-11-18 Yushan Jiang , Shuteng Niu , Dongjin Song , Yichen Wang , Jingna Feng , Xinyue Hu , Liu Yang , Cui Tao