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This study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, enabling 2D CNNs to extract volumetric…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano

Clinical natural language processing (NLP) is increasingly in demand in both clinical research and operational practice. However, most of the state-of-the-art solutions are transformers-based and require high computational resources,…

Computation and Language · Computer Science 2025-04-18 Jianlin Shi , Qiwei Gan , Elizabeth Hanchrow , Annie Bowles , John Stanley , Adam P. Bress , Jordana B. Cohen , Patrick R. Alba

Alzheimer's Dementia (AD) is an incurable, debilitating, and progressive neurodegenerative condition that affects cognitive function. Early diagnosis is important as therapeutics can delay progression and give those diagnosed vital time.…

Machine Learning · Computer Science 2023-02-28 Thomas Searle , Zina Ibrahim , Richard Dobson

Alterations in functional brain connectivity characterize neurodegenerative disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). As a non-invasive and cost-effective technique, electroencephalography (EEG) is…

Applications · Statistics 2025-11-19 Paolo Victor Redondo , Raphaël Huser , Hernando Ombao

Voice Timbre Attribute Detection (vTAD) plays a pivotal role in fine-grained timbre modeling for speech generation tasks. However, it remains challenging due to the inherently subjective nature of timbre descriptors and the severe label…

Sound · Computer Science 2025-08-25 Zhiyu Wu , Jingyi Fang , Yufei Tang , Yuanzhong Zheng , Yaoxuan Wang , Haojun Fei

Medium-horizon Alzheimer's disease progression prediction is difficult because future clinical scores can remain tied to baseline severity, while biomarker histories are irregular and incompletely observed. We develop an anchor-based…

Machine Learning · Computer Science 2026-05-19 Ran Tong , Tong Wang , Lanruo Wang , Yin Ni

Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading, increase strain, and accelerate disease progression.…

Identification of plant disease is usually done through visual inspection or during laboratory examination which causes delays resulting in yield loss by the time identification is complete. On the other hand, complex deep learning models…

Computer Vision and Pattern Recognition · Computer Science 2021-02-10 Nisar Ahmed , Hafiz Muhammad Shahzad Asif , Gulshan Saleem

Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clinical trials to track the therapeutic efficacy of…

In the complex realm of cognitive disorders, Alzheimer's disease (AD) and vascular dementia (VaD) are the two most prevalent dementia types, presenting entangled symptoms yet requiring distinct treatment approaches. The crux of effective…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Salma Hassan , Dawlat Akaila , Maryam Arjemandi , Vijay Papineni , Mohammad Yaqub

Dementia is a syndrome, generally of a chronic nature characterized by a deterioration in cognitive function, especially in the geriatric population and is severe enough to impact their daily activities. Early diagnosis of dementia is…

Audio and Speech Processing · Electrical Eng. & Systems 2020-07-21 Rupayan Chakraborty , Meghna Pandharipande , Chitralekha Bhat , Sunil Kumar Kopparapu

INTRODUCTION: Heterogeneity in the progression of Alzheimer's disease makes it challenging to predict the rate of cognitive and functional decline for individual patients. Tools for short-term prediction could help enrich clinical trial…

Quantitative Methods · Quantitative Biology 2021-01-22 Neda Shafiee , Mahsa Dadar , Simon Ducharme , D. Louis Collins

Rapid and accurate identification of Venous thromboembolism (VTE), a severe cardiovascular condition including deep vein thrombosis (DVT) and pulmonary embolism (PE), is important for effective treatment. Leveraging Natural Language…

Age-related macular degeneration (AMD) is characterized by early micro-vascular alterations that can be captured non-invasively using optical coherence tomography angiography (OCTA), yet most deep learning (DL) models rely on global…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Margalit G. Mitzner , Moinak Bhattacharya , Zhilin Zou , Chao Chen , Prateek Prasanna

INTRODUCTION: Advanced machine learning methods might help to identify dementia risk from neuroimaging, but their accuracy to date is unclear. METHODS: We systematically reviewed the literature, 2006 to late 2016, for machine learning…

Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Early diagnosis and precise treatment are essential for ASD patients. Although researchers have built many analytical models, there has been limited progress in…

Neurons and Cognition · Quantitative Biology 2018-10-30 Juntang Zhuang , Nicha C. Dvornek , Xiaoxiao Li , Pamela Ventola , James S. Duncan

Dementia, a prevalent neurodegenerative condition, is a major manifestation of Alzheimer's disease (AD). As the condition progresses from mild to severe, it significantly impairs the individual's ability to perform daily tasks…

Machine Learning · Computer Science 2023-11-06 Md Gulzar Hussain , Ye Shiren

Amyloid-$\beta$ (A$\beta$) plaques in conjunction with hyperphosphorylated tau proteins in the form of neurofibrillary tangles are the two neuropathological hallmarks of Alzheimer's disease. It is well-known that the identification of…

Alzheimers disease is a fatal progressive brain disorder that worsens with time. It is high time we have inexpensive and quick clinical diagnostic techniques for early detection and care. In previous studies, various Machine Learning…

Computation and Language · Computer Science 2021-09-27 Akshay Valsaraj , Ithihas Madala , Nikhil Garg , Veeky Baths

In this article, we analyze the morphometry of hippocampus in subjects with very mild dementia of Alzheimer's type (DAT) and nondemented controls and how it changes over a two-year period. Morphometric differences with respect to a template…