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Systematic in vivo validations of computational models of the aortic valve remain scarce, despite successful validation against in vitro data. Utilizing a combination of computed tomography and 4D flow magnetic resonance imaging data, we…

It has long been recognized that aortic root elasticity helps to ensure efficient aortic valve closure, but our understanding of the functional importance of the elasticity and geometry of the aortic root continues to evolve as increasingly…

Computational Engineering, Finance, and Science · Computer Science 2016-01-27 Vittoria Flamini , Abe DeAnda , Boyce E. Griffith

In our recent work, we introduced the reduced unified continuum formulation for vascular fluid-structure interaction (FSI) and demonstrated enhanced solver accuracy, scalability, and performance compared to conventional approaches. We…

Computational Physics · Physics 2022-03-03 Ingrid S. Lan , Ju Liu , Weiguang Yang , Judith Zimmermann , Daniel B. Ennis , Alison L. Marsden

Purpose. It has been reported clinically that rupture or dissections in thoracic aortic aneurysms (TAA) often occur due to hypertension which may be modelled with sudden increase of peripheral resistance, inducing acute changes of blood…

Understanding the complex interplay between morphologic and hemodynamic features in aortic dissection is critical for risk stratification and for the development of individualized therapy. This work evaluates the effects of entry and exit…

A microfluidic device is constructed from PDMS with a single channel having a short section that is a thin flexible membrane, in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a…

Soft Condensed Matter · Physics 2020-07-03 Debadi Chakraborty , J. Ravi Prakash , Leslie Yeo , James Friend

Flow diversion has become a key treatment modality for selected intracranial aneurysms, relying on the principle that a dense mesh of stent wires disrupts blood flow into the aneurysm sac, promoting thrombosis and vessel reconstruction.…

In fractured natural formations, the equations governing fluid flow and geomechanics are strongly coupled. Hydrodynamical properties depend on the mechanical configuration, and they are therefore difficult to accurately resolve using…

Numerical Analysis · Mathematics 2021-04-07 Matteo Cusini , Joshua A. White , Nicola Castelletto , Randolph R. Settgast

To date, endovascular surgeries are performed using the golden standard of Fluoroscopy, which uses ionising radiation to visualise catheters and vasculature. Prolonged Fluoroscopic exposure is harmful for the patient and the clinician, and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-27 Alex Ranne , Yordanka Velikova , Nassir Navab , Ferdinando Rodriguez y Baena

This study investigates the influence of aneurysm evolution on hemodynamic characteristics within the sac region. Using computational fluid dynamics (CFD), blood flow through the parent vessel and aneurysm sac was analyzed to assess the…

Quantitative Methods · Quantitative Biology 2026-02-17 Reza Bozorgpour , Jacob R. Rammer

In this chapter, we analyze the steady-state microscale fluid--structure interaction (FSI) between a generalized Newtonian fluid and a hyperelastic tube. Physiological flows, especially in hemodynamics, serve as primary examples of such FSI…

Fluid Dynamics · Physics 2019-03-12 Vishal Anand , Ivan C. Christov

The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…

Fluid Dynamics · Physics 2021-03-30 Francesco Viola , Valentina Meschini , Roberto Verzicco

Lightweight, single-use explosion containment structures provide an effective solution for neutralizing rogue explosives, combining affordability with ease of transport. This paper introduces a three-stage simulation framework that captures…

Fluid Dynamics · Physics 2026-05-21 Aditya Narkhede , Shafquat Islam , Xingsheng Sun , Kevin Wang

Topographical structures represent connections between entities and provide a comprehensive design of complex systems. Currently these structures are used to discover correlates of neuronal and haemodynamical activity. In this work, we…

Neurons and Cognition · Quantitative Biology 2022-03-08 David Calhas , Rui Henriques

In this paper we introduce a new method simulating stent graft deployment for assisting endovascular repair of abdominal aortic aneurysms. The method relies on intraoperative images coupled with mechanical models. A multi-step algorithm has…

We present a novel method for fluid structure interaction (FSI) simulations where an original 2nd-order curved space lattice Boltzmann fluid solver (LBM) is coupled to a finite element method (FEM) for thin shells. The LBM can work…

This work presents a biventricular electromechanical human heart model that is comprehensive and clinically relevant, integrating a realistic 3D heart geometry with both systemic and pulmonary hemodynamics. The model uses a two-way…

Medical Physics · Physics 2025-09-05 Milad Hasani , Alireza Rezania , Sam Riahi

The study of elastic structures embedded with fluid-filled cavities received considerable attention in fields such as autonomous materials, sensors, actuators, and smart systems. This work studies an elastic beam embedded with a set of…

Fluid Dynamics · Physics 2021-12-06 Yoav Matia , Amir D. Gat

We present a new model and a novel loosely coupled partitioned numerical scheme modeling fluid-structure interaction (FSI) in blood flow allowing non-zero longitudinal displacement. Arterial walls are modeled by a {linearly viscoelastic,…

Numerical Analysis · Mathematics 2015-06-05 Martina Bukac , Suncica Canic , Roland Glowinski , Josip Tambaca , Annalisa Quaini

Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…