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Related papers: Optimal Kidney Exchange with Immunosuppressants

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We introduce the Stackelberg kidney exchange problem. In this problem, an agent (e.g. a hospital or a national organization) has control over a number of incompatible patient-donor pairs whose patients are in need of a transplant. The agent…

Computer Science and Game Theory · Computer Science 2020-07-08 Bart Smeulders , Danny Blom , Frits C. R. Spieksma

The burgeoning need for kidney transplantation mandates immediate attention. Mismatch of deceased donor-recipient kidney leads to post-transplant death. To ensure ideal kidney donor-recipient match and minimize post-transplant deaths, the…

Computers and Society · Computer Science 2019-08-22 Ehsan Khan , Avishek Choudhury , Amy L Friedman , Daehan Won

Motivated by kidney exchange, we study a stochastic cycle and chain packing problem, where we aim to identify structures in a directed graph to maximize the expectation of matched edge weights. All edges are subject to failure, and the…

Artificial Intelligence · Computer Science 2020-07-08 Hoda Bidkhori , John P Dickerson , Duncan C McElfresh , Ke Ren

Kidney Exchange Programs (KEPs) promote access to living donor trans- plantation for patients suffering from end stage renal disease. The HLA compatibility between transplant recipients and donors plays an important role when solving the…

Optimization and Control · Mathematics 2025-10-17 Valentina Peralta Clarke , Hans de Ferrante , Francisco Perez Galarce , Joris van de Klundert

Balancing fairness and efficiency in resource allocation is a classical economic and computational problem. The price of fairness measures the worst-case loss of economic efficiency when using an inefficient but fair allocation rule; for…

Computer Science and Game Theory · Computer Science 2017-09-11 Duncan C. McElfresh , John P. Dickerson

Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the…

Machine Learning · Computer Science 2022-05-18 Andrea M. Storås , Anders Åsberg , Pål Halvorsen , Michael A. Riegler , Inga Strümke

Relatives and friends of an end-stage renal disease patient who offer to donate a kidney are often found to be incompatible with their intended recipients. Kidney paired donation matches one patient and his incompatible donor with another…

Computer Science and Game Theory · Computer Science 2017-10-24 Sommer Gentry , Michal Mankowski , T. S. Michael , Dorry Segev

We propose a simulation-optimization-based methodology to improve the way that organ transplant offers are made to potential recipients. Our policy can be applied to all types of organs, is implemented starting at the local level, is…

Medical Physics · Physics 2022-12-01 Ignacio Erazo , David Goldsman , Pinar Keskinocak , Joel Sokol

The study of matching theory has gained importance recently with applications in Kidney Exchange, House Allocation, School Choice etc. The general theme of these problems is to allocate goods in a fair manner amongst participating agents.…

Computer Science and Game Theory · Computer Science 2020-02-10 Shyam Chandramouli , Jay Sethuraman

Liver transplantation continues to be the gold standard for treating patients with end-stage liver diseases. However, despite the huge success of liver transplantation in improving patient outcomes, long term graft survival continues to be…

Other Quantitative Biology · Quantitative Biology 2023-06-02 Raja Al-Bahou , Julia Bruner , Helen Moore , Ali Zarrinpar

We design a flexible algorithm that exploits deceased donor kidneys to initiate chains of living donor kidney paired donations, combining deceased and living donor allocation mechanisms to improve the quantity and quality of kidney…

Tissues and Organs · Quantitative Biology 2019-01-09 Cristina Cornelio , Lucrezia Furian , Antonio Nicolo' , Francesca Rossi

The seminal work of Roth, S\"onmez, & \"Unver shows that the Edmonds-Gallai structure theorem for non-bipartite matching can be leveraged to yield a randomized algorithm to match patient-donor pairs in kidney exchange with extraordinarily…

Data Structures and Algorithms · Computer Science 2026-05-20 Claire Chang , Arin Khare , David Shmoys

In the query-commit problem we are given a graph where edges have distinct probabilities of existing. It is possible to query the edges of the graph, and if the queried edge exists then its endpoints are irrevocably matched. The goal is to…

Data Structures and Algorithms · Computer Science 2011-10-06 Marco Molinaro , R. Ravi

This paper introduces a new learning-based approach for approximately solving the Kidney-Exchange Problem (KEP), an NP-hard problem on graphs. The problem consists of, given a pool of kidney donors and patients waiting for kidney donations,…

Machine Learning · Computer Science 2023-04-21 Pedro Foletto Pimenta , Pedro H. C. Avelar , Luis C. Lamb

Background: The kidney exchange problem (KEP) addresses the matching of patients in need for a replacement organ with compatible living donors. Ideally many medical institutions should participate in a matching program to increase the…

Cryptography and Security · Computer Science 2022-04-22 Timm Birka , Kay Hamacher , Tobias Kussel , Helen Möllering , Thomas Schneider

One of the biggest challenges in medicine is to dampen the pathophysiological stress induced by an episode of ischemia. Such stress, due to various pathological or clinical situations, follows a restriction in blood and oxygen supply to…

Neurons and Cognition · Quantitative Biology 2019-08-12 Michel Tauc , Nicolas Melis , Miled Bourourou , Sébastien Giraud , Thierry Hauet , Nicolas Blondeau

We study an elementary path problem which appears in the pricing step of a column generation scheme solving the kidney exchange problem. The latter aims at finding exchanges of donations in a pool of patients and donors of kidney…

Data Structures and Algorithms · Computer Science 2022-01-24 Lucie Pansart , Hadrien Cambazard , Nicolas Catusse

Liver transplant can be a life-saving procedure for patients with end-stage liver disease. With the introduction of modern immunosuppressive therapies, short-term survival has significantly improved. However, long-term survival has not…

Quantitative Methods · Quantitative Biology 2024-11-28 Julia Bruner , Kyle Adams , Skylar Grey , Mahya Aghaee , Sergio Duarte , Ali Zarrinpar , Helen Moore

Consider a matching problem on a graph where disjoint sets of vertices are privately owned by self-interested agents. An edge between a pair of vertices indicates compatibility and allows the vertices to match. We seek a mechanism to…

Computer Science and Game Theory · Computer Science 2016-11-25 Itai Ashlagi , Felix Fischer , Ian A. Kash , Ariel D. Procaccia

We revisit the problem of designing optimal, individually rational matching mechanisms (in a general sense, allowing for cycles in directed graphs), where each player --- who is associated with a subset of vertices --- matches as many of…

Data Structures and Algorithms · Computer Science 2016-09-15 Avrim Blum , Ioannis Caragiannis , Nika Haghtalab , Ariel D. Procaccia , Eviatar B. Procaccia , Rohit Vaish