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With recent advances in sequencing technologies, large amounts of epigenomic data have become available and computational methods are contributing significantly to the progress of epigenetic research. As an orthogonal approach to methods…

Genomics · Quantitative Biology 2019-11-05 Alexander Lück , Verena Wolf

This paper studies the multi-reference alignment (MRA) problem of estimating a signal function from shifted, noisy observations. Our functional formulation reveals a new connection between MRA and deconvolution: the signal can be estimated…

Information Theory · Computer Science 2026-05-19 Omar Al-Ghattas , Anna Little , Daniel Sanz-Alonso , Mikhail Sweeney

Meta-analysis, because of both logistical convenience and statistical efficiency, is widely popular for synthesizing information on common parameters of interest across multiple studies. We propose developing a generalized meta-analysis…

Methodology · Statistics 2018-11-27 Prosenjit Kundu , Runlong Tang , Nilanjan Chatterjee

We propose a new exact solution algorithm for closed multiclass product-form queueing networks that is several orders of magnitude faster and less memory consuming than established methods for multiclass models, such as the Mean Value…

Performance · Computer Science 2009-02-19 Giuliano Casale

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

Information Theory · Computer Science 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

We show that a special case of method of moment estimator derived from the Stein class coincides with the class of generalized score matching estimator. Choosing a suitable weight function for generalized score matching is not…

Methodology · Statistics 2026-02-09 Alfred Kume , Stephen G. Walker

In the multireference alignment model, a signal is observed by the action of a random circular translation and the addition of Gaussian noise. The goal is to recover the signal's orbit by accessing multiple independent observations. Of…

Information Theory · Computer Science 2018-11-06 Emmanuel Abbe , Tamir Bendory , William Leeb , João Pereira , Nir Sharon , Amit Singer

Due to the ease of modern data collection, applied statisticians often have access to a large set of covariates that they wish to relate to some observed outcome. Generalized linear models (GLMs) offer a particularly interpretable framework…

Computation · Statistics 2019-05-21 Brian L. Trippe , Jonathan H. Huggins , Raj Agrawal , Tamara Broderick

A real-world application or setting involves interaction between different modalities (e.g., video, speech, text). In order to process the multimodal information automatically and use it for an end application, Multimodal Representation…

Computer Vision and Pattern Recognition · Computer Science 2022-11-08 Abhinav Joshi , Naman Gupta , Jinang Shah , Binod Bhattarai , Ashutosh Modi , Danail Stoyanov

In this paper, we propose the generalized mixed reduced rank regression method, GMR$^3$ for short. GMR$^3$ is a regression method for a mix of numeric, binary, and ordinal response variables. The predictor variables can be a mix of binary,…

Methodology · Statistics 2025-01-23 Mark de Rooij , Lorenza Cotugno , Roberta Siciliano

The Method of Moments [Pea94] is one of the most widely used methods in statistics for parameter estimation, by means of solving the system of equations that match the population and estimated moments. However, in practice and especially…

Statistics Theory · Mathematics 2019-04-16 Yihong Wu , Pengkun Yang

In this paper, we propose a method based on GMM (the generalized method of moments) to estimate the parameters of stable distributions with $0<\alpha<2$. We don't assume symmetry for stable distributions.

Statistics Theory · Mathematics 2007-06-13 Chunlin Wang

The conditional moment problem is a powerful formulation for describing structural causal parameters in terms of observables, a prominent example being instrumental variable regression. A standard approach reduces the problem to a finite…

Machine Learning · Computer Science 2023-03-24 Andrew Bennett , Nathan Kallus

We present a novel algorithm for learning the parameters of hidden Markov models (HMMs) in a geometric setting where the observations take values in Riemannian manifolds. In particular, we elevate a recent second-order method of moments…

Machine Learning · Computer Science 2023-02-16 Berlin Chen , Cyrus Mostajeran , Salem Said

We propose employing a high-dimensional generalized method of moments (GMM) estimator, regularized for dimension reduction and subsequently debiased to correct for shrinkage bias (referred to as a debiased-regularized estimator), for…

Econometrics · Economics 2025-07-03 Victor Chernozhukov , Chen Huang , Weining Wang

Instrumental variables analysis using genetic markers as instruments is now a widely used technique in epidemiology and biostatistics. As single markers tend to explain only a small proportion of phenotypic variation, there is increasing…

Methodology · Statistics 2015-04-09 Paul S. Clarke , Tom M. Palmer , Frank Windmeijer

Mixture modeling is a general technique for making any simple model more expressive through weighted combination. This generality and simplicity in part explains the success of the Expectation Maximization (EM) algorithm, in which updates…

Machine Learning · Statistics 2016-03-29 Sida I. Wang , Arun Tejasvi Chaganty , Percy Liang

Complex time series models such as (the sum of) ARMA$(p,q)$ models with additional noise, random walks, rounding errors and/or drifts are increasingly used for data analysis in fields such as biology, ecology, engineering and economics…

Methodology · Statistics 2020-01-14 Stéphane Guerrier , Roberto Molinari , Maria-Pia Victoria-Feser , Haotian Xu

This paper presents a computation method of generalized scattering matrix (GSM) based on integral equations and the method of moments (MoM), specifically designed for antennas excited through waveguide ports. By leveraging two distinct…

Signal Processing · Electrical Eng. & Systems 2025-07-18 Chenbo Shi , Jin Pan , Xin Gu , Shichen Liang , Le Zuo

We derive an asymptotic expansion for the log likelihood of Gaussian mixture models (GMMs) with equal covariance matrices in the low signal-to-noise regime. The expansion reveals an intimate connection between two types of algorithms for…

Statistics Theory · Mathematics 2020-06-30 Anya Katsevich , Afonso Bandeira