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We consider the problem of estimating parameters of stochastic differential equations (SDEs) with discrete-time observations that are either completely or partially observed. The transition density between two observations is generally…

Methodology · Statistics 2015-09-09 Libo Sun , Chihoon Lee , Jennifer A. Hoeting

While COVID-19 is rapidly propagating around the globe, the need for providing real-time forecasts of the epidemics pushes fits of dynamical and statistical models to available data beyond their capabilities. Here we focus on statistical…

Populations and Evolution · Quantitative Biology 2020-06-08 Tommaso Alberti , Davide Faranda

In this paper, we present the Partial Integral Equation (PIE) representation of linear Partial Differential Equations (PDEs) in one spatial dimension, where the PDE has spatial integral terms appearing in the dynamics and the boundary…

Numerical Analysis · Mathematics 2022-12-19 Sachin Shivakumar , Amritam Das , Matthew Peet

Epidemic models are invaluable tools to understand and implement strategies to control the spread of infectious diseases, as well as to inform public health policies and resource allocation. However, current modeling approaches have…

Methodology · Statistics 2026-05-12 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

Two stochastic models are proposed to describe the evolution of the COVID-19 pandemic. In the first model the population is partitioned into four compartments: susceptible $S$, infected $I$, removed $R$ and dead people $D$. In order to have…

Populations and Evolution · Quantitative Biology 2021-09-16 Fabiana Calleri , Giovanni Nastasi , Vittorio Romano

During the ongoing COVID-19 pandemic, mathematical models of epidemic spreading have emerged as powerful tools to produce valuable predictions of the evolution of the pandemic, helping public health authorities decide which intervention…

Dynamical Systems · Mathematics 2021-11-18 Lorenzo Zino , Ming Cao

This review maps developments in stochastic modeling, highlighting non-standard approaches and their applications to biology and epidemiology. It brings together four strands: (1) core models for systems that evolve with randomness; (2)…

Dynamical Systems · Mathematics 2025-10-24 Yassine Sabbar , Kottakkaran Sooppy Nisar

During 2020, the infection rate of COVID-19 has been investigated by many scholars from different research fields. In this context, reliable and interpretable forecasts of disease incidents are a vital tool for policymakers to manage…

Machine Learning · Computer Science 2021-01-05 Cornelius Fritz , Emilio Dorigatti , David Rügamer

Over a year after the start of the COVID-19 epidemics, we are still facing the virus and it is hard to correctly predict its future spread over weeks to come, as well as the impacts of potential political interventions. Current epidemic…

Multiagent Systems · Computer Science 2021-12-03 Benoit Doussin , Carole Adam , Didier Georges

As global living standards improve and medical technology advances, many infectious diseases have been effectively controlled. However, certain diseases, such as the recent COVID-19 pandemic, continue to pose significant threats to public…

Numerical Analysis · Mathematics 2025-02-24 Ayesha Baig , Li Zhouxin

The coronavirus disease 2019 (COVID-19) pandemic radically impacts our lives, while the transmission/infection and recovery dynamics of COVID-19 remain obscure. A time-dependent Susceptible, Exposed, Infectious, and Recovered (SEIR) model…

Populations and Evolution · Quantitative Biology 2020-04-01 Yong Zhang , Xiangnan Yu , HongGuang Sun , Geoffrey R. Tick , Wei Wei , Bin Jin

Delay differential equations are of great importance in science, engineering, medicine and biological models. These type of models include time delay phenomena which is helpful for characterising the real-world applications in machine…

Numerical Analysis · Mathematics 2021-03-17 Burcu Gürbüz

This work proposes a method to compute the maximum value obtained by a state function along trajectories of a Delay Differential Equation (DDE). An example of this task is finding the maximum number of infected people in an epidemic model…

Optimization and Control · Mathematics 2023-04-06 Jared Miller , Milan Korda , Victor Magron , Mario Sznaier

Breaking a complex bio-social phenomenon (epidemic) into its components, considering the processes that determine its dynamics, formalizing the accepted hypotheses in mathematical equations, selecting appropriate experimental and…

Physics and Society · Physics 2020-06-16 A. V. Sokolov , L. A. Sokolova

In this article, we introduce a system of stochastic differential equations (SDEs) consisting of time-dependent covariates and consider both fixed and random effects set-ups. We also allow the functional part associated with the drift…

Statistics Theory · Mathematics 2017-10-16 Trisha Maitra , Sourabh Bhattacharya

Given the ongoing Covid-19 pandemic, it is of interest to understand how the infections spread as the combined result of measures taken by central planners (governments) and individual behavior. In this work, the spread of Covid-19 is…

Populations and Evolution · Quantitative Biology 2021-10-01 Sushant Vijayan

How can we learn a dynamical system to make forecasts, when some variables are unobserved? For instance, in COVID-19, we want to forecast the number of infected and death cases but we do not know the count of susceptible and exposed people.…

Machine Learning · Computer Science 2021-04-30 Rui Wang , Danielle Maddix , Christos Faloutsos , Yuyang Wang , Rose Yu

The COVID-19 pandemic has posed a heavy burden to the healthcare system worldwide and caused huge social disruption and economic loss. Many deep learning models have been proposed to conduct clinical predictive tasks such as mortality…

Machine Learning · Computer Science 2024-01-24 Junyi Gao , Yinghao Zhu , Wenqing Wang , Yasha Wang , Wen Tang , Ewen M. Harrison , Liantao Ma

The recent coronavirus disease (COVID-19) outbreak has dramatically increased the public awareness and appreciation of the utility of dynamic models. At the same time, the dissemination of contradictory model predictions has highlighted…

Populations and Evolution · Quantitative Biology 2020-06-26 Gemma Massonis , Julio R. Banga , Alejandro F. Villaverde

This paper extends the canonical model of epidemiology, SIRD model, to allow for time varying parameters for real-time measurement of the stance of the COVID-19 pandemic. Time variation in model parameters is captured using the generalized…

Populations and Evolution · Quantitative Biology 2021-02-11 Cem Cakmakli , Yasin Simsek