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Operating systems have historically had to manage only a single type of memory device. The imminent availability of heterogeneous memory devices based on emerging memory technologies confronts the classic single memory model and opens a new…

Molecular dynamics (MD) simulations provide considerable benefits for the investigation and experimentation of systems at atomic level. Their usage is widespread into several research fields, but their system size and timescale are also…

Quantum computers promise to solve certain problems that are intractable for classical computers, such as factoring large numbers and simulating quantum systems. To date, research in quantum computer engineering has focused primarily at…

Previous schemes for designing secure branch prediction unit (SBPU) based on physical isolation can only offer limited security and significantly affect BPU's prediction capability, leading to prominent performance degradation. Moreover,…

Cryptography and Security · Computer Science 2025-01-22 Zhe Zhou , Fei Tong , Hongyu Wang , Xiaoyu Cheng , Fang Jiang , Zhikun Zhang , Yuxing Mao

Kernel methods are a cornerstone of classical machine learning. The idea of using quantum computers to compute kernels has recently attracted attention. Quantum embedding kernels (QEKs) constructed by embedding data into the Hilbert space…

The rise of data-intensive applications exposed the limitations of conventional processor-centric von-Neumann architectures that struggle to meet the off-chip memory bandwidth demand. Therefore, recent innovations in computer architecture…

Hardware Architecture · Computer Science 2024-05-28 Asif Ali Khan , Hamid Farzaneh , Karl F. A. Friebel , Clément Fournier , Lorenzo Chelini , Jeronimo Castrillon

Sequence alignment is a fundamental process in computational biology which identifies regions of similarity in biological sequences. With the exponential growth in the volume of data in bioinformatics databases, the time, processing power,…

Hardware Architecture · Computer Science 2025-07-31 Nasrin Akbari , Mehdi Modarressi , Alireza Khadem

Over the past decade, U-Net has been the dominant architecture in medical image segmentation, leading to the development of thousands of U-shaped variants. Despite its widespread adoption, there is still no comprehensive benchmark to…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Fenghe Tang , Chengqi Dong , Wenxin Ma , Zikang Xu , Heqin Zhu , Zihang Jiang , Rongsheng Wang , Yuhao Wang , Chenxu Wu , Shaohua Kevin Zhou

Protein structure prediction models such as AlphaFold3 (AF3) push the frontier of biomolecular modeling by incorporating science-informed architectural changes to the transformer architecture. However, these advances come at a steep system…

Biomolecules · Quantitative Biology 2025-06-27 Hoa La , Ahan Gupta , Alex Morehead , Jianlin Cheng , Minjia Zhang

Designing a qubit architecture is one of the most critical challenges in achieving scalable and fault-tolerant quantum computing as the performance of a quantum computer is heavily dependent on the coherence times, connectivity and low…

As quantum computing hardware rapidly advances, objectively evaluating the capabilities and error rates of new processors remains a critical challenge for the field. A clear and realistic understanding of current quantum performance is…

Quantum Physics · Physics 2026-04-21 Nitay Mayo , Tal Mor , Yossi Weinstein

Representation learning is an important step in the machine learning pipeline. Given the current biological sequencing data volume, learning an explicit representation is prohibitive due to the dimensionality of the resulting feature…

Machine Learning · Computer Science 2023-04-04 Sarwan Ali , Usama Sardar , Murray Patterson , Imdad Ullah Khan

In this work we present the Secure Machine, SeM for short, a CPU architecture extension for secure computing. SeM uses a small amount of in-chip additional hardware that monitors key communication channels inside the CPU chip, and only acts…

Cryptography and Security · Computer Science 2018-03-13 Ofir Shwartz , Yitzhak Birk

Effective training of today's large language models (LLMs) depends on large batches and long sequences for throughput and accuracy. To handle variable-length sequences on hardware accelerators, it is common practice to introduce padding…

Computation and Language · Computer Science 2022-10-07 Mario Michael Krell , Matej Kosec , Sergio P. Perez , Andrew Fitzgibbon

Compute in-memory (CIM) is a promising technique that minimizes data transport, the primary performance bottleneck and energy cost of most data intensive applications. This has found wide-spread adoption in accelerating neural networks for…

Hardware Architecture · Computer Science 2020-08-18 Brian Crafton , Samuel Spetalnick , Gauthaman Murali , Tushar Krishna , Sung-Kyu Lim , Arijit Raychowdhury

Increasing amounts of data from varied sources, particularly in the fields of machine learning and graph analytics, are causing storage requirements to grow rapidly. A variety of technologies exist for storing and sharing these data,…

Recently, hybrid architectures using accelerators like GPGPUs or the Cell processor have gained much interest in the HPC community. The RapidMind Multi-Core Development Platform is a programming environment that allows generating code which…

Performance · Computer Science 2010-02-19 Iris Christadler , Volker Weinberg

We present a mechanism to symbolically gather performance-relevant operation counts from numerically-oriented subprograms (`kernels') expressed in the Loopy programming system, and apply these counts in a simple, linear model of kernel run…

Performance · Computer Science 2016-04-19 James Stevens , Andreas Klöckner

We describe a universal modeling approach for predicting single- and multicore runtime of steady-state loops on server processors. To this end we strictly differentiate between application and machine models: An application model comprises…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-30 Johannes Hofmann , Christie L. Alappat , Georg Hager , Dietmar Fey , Gerhard Wellein

Ensuring that software performance does not degrade after a code change is paramount. A solution is to regularly execute software microbenchmarks, a performance testing technique similar to (functional) unit tests, which, however, often…

Software Engineering · Computer Science 2024-04-19 Christoph Laaber , Tao Yue , Shaukat Ali
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